| Signal recognition particle, putative [Q4QAR0] | |
|---|---|
| Systematic Name | LmjF.24.0730 [Leishmania major] |
| Gene Name | LMJF_24_0730 |
| Molecular Weight | 56778 Da |
| Protein Sequence Size | 519 |
| Function | |
| Charge | 14.5 |
| Isoelectric Point | 9.8 pH |
| Description | Signal recognition particle, putative. |
| Subcellular Location | signal recognition particle (sensu Eukaryota)[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QAR0|Q4QAR0_LEIMA Signal recognition particle, putative - Leishmania major VLAELGQKIGQAIHRMSAKSMLGEDDVKELMNEIARALLQADVNVTIVKKLQVSIRTELA LAEEGAGLNKRKILQNAVFNGLKRILDPGVKPFLPVKGRHNVVMFVGLQGSGKTTSCTKY AAYFQRKGFKTALVCADTFRAGAYDQLRQNATKAKVRFYGSLTEADPVAIAKEGVAELKK EKYDLIIVDTSGRHKQESALFEEMKQVEEAVKPNDIVFVMSATDGQAVEEQARNFKEMVA VGSVIVTKLDCQTKGGGALSAVAATRSPIVFIGTGEHFEDFDLFNPERFVQKMLGMGDIG GLMDTMRDANIDGNEEVYKRLQDGLFTMRDMYEHLQNVLKMGSVGKIMEMLPGMSGHAAT AGQQGDIALKGFIHMLDSMTVAELDEVRVKKMMTPSRMHRIARGSGHSVVEVQNLIISYT KFEEIVKKMGKMNFKAMMQDSSGPAAGHMGQQQMGQLAKLLNPNMLRQIGGMGGLQGMMK QLQQSMGGGAGGAGGLPDMSAMANMMQMMQQHQKPPRR |
| DNA Sequence | >LmjF24.0730 |||signal recognition particle, putative|Leishmania major|chr 24|||Manual ATGGTCTTGG CAGAGCTGGG TCAGAAAATC GGGCAGGCGA TTCATCGCAT GTCCGCCAAGTCGATGCTGG GTGAGGACGA TGTGAAGGAG CTGATGAACG AGATTGCGCG TGCGCTGCTGCAGGCAGACG TGAACGTCAC CATTGTGAAG AAGCTTCAGG TGAGCATCAG AACGGAGCTGGCACTAGCGG AGGAGGGCGC TGGACTGAAC AAGCGCAAGA TCCTTCAGAA CGCTGTCTTCAATGGCCTCA AGCGCATACT CGACCCCGGG GTGAAGCCGT TCCTACCGGT GAAGGGGAGGCACAACGTCG TGATGTTTGT GGGTCTGCAA GGGTCCGGCA AGACGACATC GTGCACGAAGTACGCCGCCT ACTTTCAGCG CAAGGGCTTC AAGACGGCGC TGGTGTGCGC CGACACGTTCCGCGCTGGCG CGTACGATCA GCTGCGTCAG AACGCGACCA AGGCCAAGGT ACGCTTCTACGGATCACTGA CGGAGGCAGA CCCGGTAGCG ATCGCCAAGG AAGGTGTGGC GGAACTCAAGAAGGAGAAGT ACGACCTCAT CATCGTAGAC ACGAGTGGCC GCCATAAGCA GGAGTCGGCGCTCTTTGAGG AGATGAAGCA GGTCGAGGAA GCCGTGAAGC CGAACGACAT CGTCTTCGTCATGTCCGCGA CAGACGGGCA GGCGGTAGAG GAGCAGGCAC GCAACTTCAA GGAAATGGTTGCTGTCGGCT CGGTCATTGT CACGAAGCTA GACTGCCAGA CCAAGGGCGG CGGTGCGCTCTCCGCCGTCG CGGCGACGCG CAGCCCCATC GTCTTCATCG GCACCGGCGA GCACTTCGAGGACTTCGACC TCTTTAATCC GGAGCGGTTT GTGCAGAAGA TGTTGGGCAT GGGCGACATAGGCGGGCTGA TGGACACGAT GCGCGACGCC AACATCGACG GCAACGAGGA AGTCTACAAGCGCCTGCAGG ACGGCCTGTT CACAATGCGT GACATGTACG AACATCTGCA GAACGTGCTCAAGATGGGCT CCGTTGGTAA AATCATGGAA ATGCTGCCCG GCATGTCGGG CCACGCCGCTACGGCGGGCC AGCAGGGCGA CATTGCGCTG AAGGGGTTTA TCCACATGCT AGACAGCATGACGGTCGCCG AGCTGGATGA AGTCAGGGTG AAGAAGATGA TGACACCATC CCGCATGCACCGCATCGCGC GCGGCAGCGG CCACTCCGTC GTCGAGGTGC AGAACCTGAT TATTAGCTATACGAAGTTTG AGGAGATCGT GAAGAAGATG GGCAAGATGA ACTTCAAGGC CATGATGCAGGACTCTTCCG GGCCCGCCGC GGGGCACATG GGGCAGCAGC AGATGGGTCA GCTGGCGAAGCTGCTCAACC CGAACATGCT ACGGCAGATC GGCGGCATGG GTGGACTGCA GGGGATGATGAAGCAGCTGC AGCAGAGCAT GGGTGGTGGT GCGGGCGGCG CAGGCGGGCT GCCAGATATGTCCGCCATGG CCAACATGAT GCAGATGATG CAGCAGCATC AGAAGCCGCC GCGGCGGTGA |
| Signal recognition particle, putative Q4QAR0] | |
|---|---|
| Metabolite Information | |
| Molecular Function | GTP binding; GTPase activity; RNA binding; nucleoside-triphosphatase activity; nucleotide binding |
| Biochemical Pathway | SRP-dependent cotranslational protein targeting to membrane; protein targeting |
| Regulatory Pathway | |
| KEGG Pathways | K03106 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | signal recognition particle 54kDa [Homo sapiens] | 49 | 1e-126 | 450 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| ffh signal recognition particle | Bacillus subtilis | 30% | 6e-54 | 206 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 108-115; | PS00017 | |
| PDOC50099 | Sequence regions enriched in a particular amino acids | 10.015 | 430-510 | PS50320 |
| PDOC00272 | SRP54-type proteins GTP-binding domain signature | 269-282; | PS00300 | |
| Acylation | N-myristoylation site | 7-12; 66-71; 108-113; 111-116; 257-262; 258-263; 302-307; 405-410; 471-476; 474-479; 488-493; 489-494; 490-495; 492-497; | PS00008 | |
| Glycosylation | N-glycosylation site | 45-48; 151-154; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 162-165; 164-167; 222-225; 248-251; 306-309; 328-331; 381-384; 409-412; 421-424; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 18-20; 55-57; 112-114; 139-141; 192-194; 306-308; 328-330; | PS00005 | |
| Signal recognition particle, putative [Q4QAR0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2j37W | |
| Percent Identity | 49% | |
| Target Region | 9-488 | |
| Template Region | 9-479 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1828902/Q4QAR0.pdb 2.0 476 = residues | | = | *| Ramachandran plot: 86.5% core 10.3% allow 1.7% gener 1.4% = disall | | = | *| All Ramachandrans: 36 labelled residues (out of 474) = | *| Chi1-chi2 plots: 9 labelled residues (out of 293) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 10.0 Bad contacts: = 19 | *| Bond len/angle: 13.8 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | +| G-factors Dihedrals: -0.04 Covalent: -0.56 Overall: = -0.23 | | = | | M/c bond lengths: 97.0% within limits 3.0% highlighted = | *| M/c bond angles: 90.1% within limits 9.9% highlighted 10 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |