| Ring-box protein, putative [Q4QAH0] | |
|---|---|
| Systematic Name | LmjF.24.1610 [Leishmania major] |
| Gene Name | LMJF_24_1610 |
| Molecular Weight | 13078 Da |
| Protein Sequence Size | 119 |
| Function | |
| Charge | -4.5 |
| Isoelectric Point | 4.6338 pH |
| Description | Ring-box protein, putative. |
| Subcellular Location | ubiquitin ligase complex[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QAH0|Q4QAH0_LEIMA Ring-box protein, putative - Leishmania major SAEPTSTTAAASNAAPPQALMPGGRQLFTVEEFYPVYFSAWERETGLCSICCNQVEGPCV VCQSNAEATSAECSITWGECGHAFHTHCIEKWLKTRPVCPLDNKEWKDRSDWNTSATV |
| DNA Sequence | >LmjF24.1610 |||ring-box protein, putative|Leishmania major|chr 24|||Manual ATGTCAGCTG AACCCACTTC TACCACTGCC GCTGCTTCTA ATGCAGCACC ACCACAAGCGTTAATGCCGG GAGGCCGGCA ACTCTTCACC GTGGAGGAGT TCTACCCGGT CTACTTCTCTGCCTGGGAGC GTGAGACGGG TCTGTGTAGC ATCTGCTGCA ACCAAGTCGA GGGGCCGTGCGTCGTGTGCC AGAGCAACGC GGAGGCCACC TCGGCGGAGT GCAGCATCAC ATGGGGCGAGTGCGGCCATG CCTTCCATAC CCATTGCATT GAGAAATGGC TGAAGACGCG GCCAGTGTGCCCGCTCGACA ACAAGGAGTG GAAAGACCGC TCAGACTGGA ACACCTCCGC CACCGTATAG |
| Ring-box protein, putative Q4QAH0] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ubiquitin-protein ligase activity; zinc ion binding |
| Biochemical Pathway | protein ubiquitination |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | ring-box 1 [Homo sapiens] | 50 | 5e-23 | 102 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YOL133w finger protein | Saccharomyces cerevisiae | 44% | 2e-20 | 91.3 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 114-117; | PS00722 | |
| PDOC00449 | Zinc finger RING-type signature and profile | 10.94 | 60-104 | PS50089 |
| Glycosylation | N-glycosylation site | 114-117; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 30-33; 40-43; 65-68; 70-73; 77-80; | PS00006 | |
| Ring-box protein, putative [Q4QAH0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2hyeD | |
| Percent Identity | 50% | |
| Target Region | 26-119 | |
| Template Region | 19-90 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 23713-49-7 | ZINC ION | 65.409 | Zn | [Zn+2] | 2hye |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1539608/Q4QAH0.pdb 2.0 94 = residues | | = | *| Ramachandran plot: 75.0% core 21.4% allow 3.6% gener 0.0% = disall | | = | *| All Ramachandrans: 8 labelled residues (out of 92) = | | Chi1-chi2 plots: 0 labelled residues (out of 53) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 9.9 Bad contacts: = 3 | *| Bond len/angle: 7.5 Morris et al class: 2 = 1 3 | | = | | G-factors Dihedrals: -0.21 Covalent: -0.47 Overall: = -0.30 | | = | | M/c bond lengths: 98.5% within limits 1.5% highlighted = | | M/c bond angles: 88.6% within limits 11.4% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |