| 3-oxoacyl-(Acyl-carrier protein) reductase, putative [Q4QAC7] | |
|---|---|
| Systematic Name | LmjF.24.2030 [Leishmania major] |
| Gene Name | LMJF_24_2030 |
| Molecular Weight | 26982 Da |
| Protein Sequence Size | 259 |
| Function | |
| Charge | 7.5 |
| Isoelectric Point | 9 pH |
| Description | 3-oxoacyl-(Acyl-carrier protein) reductase, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QAC7|Q4QAC7_LEIMA 3-oxoacyl-(Acyl-carrier protein) reductase, putative - Leishmania major. HAKSIQSITGRPILVTGAASGLGAATARFLAQMGAKVTLLDRNAAQGEQVSKEINGKFVA TDVCSETEVQAAIKAAEVFAGKPLFGVVNCAGICPAAKVVGKKGAHSLDLFNKAVQVNLV GTFNVCRLAAEAMQRNAAQIGADEDRGVIVNTASVAAYEGQIGQAAYAASKGGIVSLTLP LAREFAGQRIRVNTICPGIMETPLLPPDLGAALGAVVPYPPRLGKPEEFAHLVFFLFSNR YMNGECIRLDGATRMAAK |
| DNA Sequence | >LmjF24.2030 |||3-oxoacyl-(acyl-carrier protein) reductase, putative|Leishmania major|chr 24|||Manual ATGCACGCCA AGTCCATCCA GTCGATTACC GGCCGCCCCA TCCTCGTGAC AGGGGCGGCCTCCGGGCTCG GGGCCGCCAC CGCACGCTTT CTCGCGCAGA TGGGCGCCAA GGTGACGCTGCTGGACCGCA ACGCGGCGCA GGGTGAGCAG GTGTCGAAGG AGATCAACGG CAAGTTTGTTGCCACAGATG TCTGTAGCGA GACCGAGGTA CAGGCGGCCA TCAAGGCAGC GGAGGTGTTCGCCGGCAAGC CGCTCTTCGG CGTCGTCAAC TGTGCCGGCA TCTGCCCAGC GGCGAAGGTCGTAGGCAAGA AGGGTGCTCA CTCCCTCGAC CTCTTCAACA AGGCTGTGCA GGTGAACCTCGTGGGTACGT TCAACGTATG CCGGCTGGCC GCCGAAGCGA TGCAGCGAAA CGCCGCGCAGATCGGCGCTG ATGAGGACCG GGGCGTTATT GTGAACACCG CGAGTGTGGC GGCCTATGAGGGTCAGATCG GTCAGGCTGC CTATGCAGCC AGCAAGGGCG GCATCGTGAG TCTGACACTGCCGTTGGCCC GCGAGTTTGC TGGGCAGCGG ATTCGCGTCA ACACCATCTG CCCCGGTATTATGGAGACAC CACTGCTGCC GCCCGACTTG GGTGCAGCGC TAGGGGCGGT TGTCCCGTACCCGCCCCGTC TTGGCAAGCC CGAGGAGTTT GCGCACCTGG TCTTCTTTCT CTTCTCGAACCGATACATGA ACGGCGAGTG CATTCGCCTT GACGGGGCAA CCCGTATGGC AGCCAAGTAG |
| 3-oxoacyl-(Acyl-carrier protein) reductase, putative Q4QAC7] | |
|---|---|
| Metabolite Information | |
| Molecular Function | NAD binding; catalytic activity; oxidoreductase activity |
| Biochemical Pathway | metabolism; nucleotide-sugar metabolism |
| Regulatory Pathway | |
| KEGG Pathways | K00022 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | hydroxyacyl-Coenzyme A dehydrogenase, type II isoform 1 [Homo sapiens] | 44 | 7e-46 | 181 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| fabG 3-ketoacyl-(acyl-carrier-protein) reductase | Mycobacterium tuberculosis H37Rv | 33% | 5e-20 | 92 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00060 | Short-chain dehydrogenases/reductases family signature | 155-183; | PS00061 | |
| Acylation | N-myristoylation site | 18-23; 22-27; 24-29; 35-40; 87-92; 93-98; 148-153; 173-178; 211-216; | PS00008 | |
| Amidation | Amidation site | 101-104; | PS00009 | |
| Phosphorylation | Casein kinase II phosphorylation site | 39-42; 66-69; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 10-12; 27-29; 239-241; | PS00005 | |
| 3-oxoacyl-(Acyl-carrier protein) reductase, putative [Q4QAC7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1uayB | |
| Percent Identity | 47% | |
| Target Region | 1-258 | |
| Template Region | 1-238 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASN | 119 | Sidechain |
| SER | 155 | Sidechain |
| TYR | 168 | Sidechain |
| LYS | 172 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 524-69-6 | ADENOSINE | 267.241 | C10 H13 N5 O4 | n2c1c(ncnc1n(c2)C3OC(C(O)C3O)CO)N | 1uay |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/3206994/Q4QAC7.pdb 2.0 259 = residues | | = | +| Ramachandran plot: 92.7% core 6.8% allow 0.5% gener 0.0% = disall | | = | *| All Ramachandrans: 9 labelled residues (out of 257) = | +| Chi1-chi2 plots: 1 labelled residues (out of 126) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 10.5 Bad contacts: = 5 | *| Bond len/angle: 6.9 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.10 Covalent: -0.16 Overall: = 0.00 | | = | | M/c bond lengths: 98.8% within limits 1.2% highlighted = | | M/c bond angles: 94.4% within limits 5.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |