| Electron transfer flavoprotein, putative [Q4QA84] | |
|---|---|
| Systematic Name | LmjF.25.0120 [Leishmania major] |
| Gene Name | LMJF_25_0120 |
| Molecular Weight | 28240 Da |
| Protein Sequence Size | 258 |
| Function | |
| Charge | 6 |
| Isoelectric Point | 9.1 pH |
| Description | Electron transfer flavoprotein, putative. |
| Subcellular Location | Mitochondrion[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QA84|Q4QA84_LEIMA Electron transfer flavoprotein, putative - Leishmania major FRTIPNYLKVAVCVKRVVDYTVKVRVKDNKVQTANSKMSVNPFDEIAIEEAIQLKEKKIA DEVVAITIGGKKAEEVLRTAMALGCDKAVHVVIPDTAVDSVEPLAVAQILQKLHEEIMPD IWVLGKQAVDGDFGCTAQLLAGLLDVPQGTFASKVEVKDKKVTVTREVDAGRQVVELSMP CVLAADLRLNTPRFPKLPNIMKARKKPIDTKDVKALGVDITPRLSTETVTEPAARKAGVK VKTVDEFYDKLLAAKVL |
| DNA Sequence | >LmjF25.0120 |||electron transfer flavoprotein, putative|Leishmania major|chr 25|||Manual ATGTTCCGCA CGATCCCGAA CTACCTCAAG GTTGCGGTGT GCGTGAAGCG CGTCGTGGACTACACGGTCA AGGTGCGCGT GAAAGACAAC AAGGTGCAGA CGGCCAACTC GAAAATGAGCGTGAACCCCT TCGACGAAAT TGCGATCGAG GAGGCGATAC AGCTCAAGGA GAAGAAAATTGCGGATGAGG TGGTGGCCAT CACGATTGGT GGCAAGAAGG CGGAGGAGGT CCTGCGCACAGCCATGGCCC TTGGGTGTGA TAAAGCCGTG CATGTTGTCA TCCCGGACAC CGCAGTGGACTCCGTGGAAC CGCTGGCGGT GGCTCAGATA CTTCAAAAGC TGCACGAGGA GATCATGCCGGATATTTGGG TGCTGGGTAA GCAGGCCGTT GACGGTGACT TCGGGTGCAC CGCGCAGTTGCTCGCCGGGC TGTTAGACGT CCCGCAGGGC ACCTTTGCTT CCAAGGTAGA GGTGAAGGATAAGAAGGTAA CTGTGACGCG TGAGGTGGAC GCCGGCCGGC AGGTGGTGGA GCTGTCGATGCCGTGCGTTC TGGCGGCAGA TTTGCGCCTC AATACACCCC GCTTCCCGAA GCTGCCAAACATCATGAAGG CGCGAAAGAA GCCCATCGAC ACGAAGGACG TGAAGGCACT CGGCGTGGACATCACGCCCC GCCTCTCAAC GGAGACCGTG ACCGAACCCG CCGCCCGCAA GGCCGGCGTTAAGGTGAAGA CGGTAGACGA GTTCTACGAC AAGCTGCTCG CGGCAAAGGT GCTCTAG |
| Electron transfer flavoprotein, putative Q4QA84] | |
|---|---|
| Metabolite Information | |
| Molecular Function | electron carrier activity; electron transporter activity |
| Biochemical Pathway | electron transport |
| Regulatory Pathway | |
| KEGG Pathways | K03521 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | electron-transfer-flavoprotein, beta polypeptide isoform 1 [Homo sapiens] | 46 | 7e-57 | 217 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| fixA PROBABLE ELECTRON TRANSFER FLAVOPROTEIN (BETA-SUBUNIT) FIXA (BETA-ETF) (ELECTRON TRANSFER FLAVOPROTEIN SMALL SUBUNIT) (ETFSS) | Mycobacterium tuberculosis H37Rv | 27% | 5e-18 | 85.5 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 70-75; 85-90; 150-155; | PS00008 | |
| Amidation | Amidation site | 70-73; | PS00009 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 161-164; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 97-100; 154-157; 229-232; 244-247; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 22-24; 192-194; 222-224; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 243-249; | PS00007 | |
| Electron transfer flavoprotein, putative [Q4QA84] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1efpD | |
| Percent Identity | 49% | |
| Target Region | 1-258 | |
| Template Region | 1-246 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 61-19-8 | ADENOSINE MONOPHOSPHATE  | 347.221 | C10 H14 N5 O7 P   | O=P(O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 1efp |
| 16426-55-4 | FLAVIN-ADENINE DINUCLEOTIDE | 785.55 | C27 H33 N9 O15 P2 | O=C2C3=Nc1cc(c(cc1N(C3=NC(=O)N2)CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC6OC(n5cnc4c(ncnc45)N)C(O)C6O)C)C | 1efp |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/72624/Q4QA84.pdb 2.0 258 = residues | | = | +| Ramachandran plot: 92.2% core 6.9% allow 0.9% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 256) = | +| Chi1-chi2 plots: 4 labelled residues (out of 143) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.3 Bad contacts: = 5 | *| Bond len/angle: 5.3 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.04 Covalent: -0.14 Overall: = -0.03 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 94.7% within limits 5.3% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |