| Eukaryotic initiation factor 5a, putative [Q4QA21] | |
|---|---|
| Systematic Name | LmjF.25.0720 [Leishmania major] |
| Gene Name | EIF5A2 |
| Molecular Weight | 17812 Da |
| Protein Sequence Size | 166 |
| Function | The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond |
| Charge | -8 |
| Isoelectric Point | 4.6159 pH |
| Description | Eukaryotic initiation factor 5a, putative. |
| Subcellular Location | cytoplasm[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QA21|Q4QA21_LEIMA Eukaryotic initiation factor 5a, putative - Leishmania major SDEDHDFSHQGGGDNASKTYPLPAGALKKGGYVCINGRPCKVIDLSVSKTGKHGHAKVSI VATDIFTGNRLEDQAPSTHNVEVPFVKTFTYSVLDIQPNEDSSLPSHLSLMDDEGESRED LDMPPDAALAAQIKEQFDSGKEVLVVVVSAMGTEQVLQTKNAAEK |
| DNA Sequence | >LmjF25.0720 |EIF5A1||eukaryotic initiation factor 5a, putative|Leishmania major|chr 25|||Manual ATGTCTGACG AGGACCATGA CTTCTCGCAC CAGGGAGGTG GCGACAACGC GTCAAAGACGTATCCCTTGC CCGCTGGCGC CCTGAAGAAG GGTGGCTACG TGTGCATCAA CGGCCGTCCGTGCAAGGTGA TCGACCTGTC TGTGTCGAAG ACCGGCAAGC ACGGTCACGC TAAGGTGAGCATTGTCGCGA CCGACATTTT CACTGGAAAC CGCCTCGAGG ATCAGGCCCC GTCCACGCACAATGTAGAGG TGCCGTTTGT GAAGACCTTC ACATACAGCG TGTTGGATAT CCAACCCAACGAAGACTCCT CTCTTCCATC TCATTTGTCG CTGATGGACG ATGAGGGCGA GAGCCGCGAGGATCTCGATA TGCCCCCGGA CGCGGCCCTG GCAGCGCAAA TCAAGGAGCA GTTCGACTCCGGCAAGGAGG TGCTAGTTGT GGTTGTGTCT GCAATGGGCA CTGAGCAGGT GTTGCAGACGAAGAATGCTG CGGAGAAGTA G |
| Eukaryotic initiation factor 5a, putative Q4QA21] | |
|---|---|
| Metabolite Information | |
| Molecular Function | nucleic acid binding; translation initiation factor activity |
| Biochemical Pathway | translational initiation |
| Regulatory Pathway | |
| KEGG Pathways | K03263 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | eukaryotic translation initiation factor 5A [Homo sapiens] | 41 | 5e-31 | 130 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00274 | Eukaryotic initiation factor 5A hypusine signature | 51-58; | PS00302 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 16-19; | PS00722 | |
| Acylation | N-myristoylation site | 12-17; 13-18; 31-36; | PS00008 | |
| Glycosylation | N-glycosylation site | 16-19; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 2-5; 93-96; 110-113; 118-121; 140-143; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 51-53; 140-142; | PS00005 | |
| Eukaryotic initiation factor 5a, putative [Q4QA21] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1xtdA | |
| Percent Identity | 90% | |
| Target Region | 16-166 | |
| Template Region | 24-149 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
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| Residue | Active Site Number | Functional Part |
| Co-Factor | |
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| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
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| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2198215/Q4QA21.pdb 2.0 151 = residues | | = | +| Ramachandran plot: 95.4% core 3.8% allow 0.8% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 149) = | +| Chi1-chi2 plots: 1 labelled residues (out of 80) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.0 Bad contacts: = 0 | *| Bond len/angle: 5.3 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.06 Covalent: -0.13 Overall: = -0.01 | | = | | M/c bond lengths: 99.9% within limits 0.1% highlighted = | | M/c bond angles: 94.2% within limits 5.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |