| Aldehyde dehydrogenase, mitochondrial [Q4Q9Y1] | |
|---|---|
| Systematic Name | LmjF.25.1120 [Leishmania major] |
| Gene Name | ALDH2 |
| Molecular Weight | 54119 Da |
| Protein Sequence Size | 499 |
| Function | |
| Charge | 3 |
| Isoelectric Point | 7 pH |
| Description | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 1.2.1.3 |
| Sequence | >tr|Q4Q9Y1|Q4Q9Y1_LEIMA Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) - Leishmania major LRATLTRLEMAPKVIHIQDKLLINGKFVPAVSGKTFEVVNPANEEVIANVAEAETADVNL AVNAARHAFESFRMTDGHWRRNLMLRLADILEKNSKEMAALESLDNGKPYEVALNVDVAL SVECFRYCAGLADKVNGTVPPRSGNFLGIVKREPIGVCGQIIPWNFPLLMAAFKLSPALA LGNTVVLKPAEQTPLSVLCLGEMAMEAGYPNGVLNILPGFGATAGADIARHMDVDKVAFT GSTAVGHQVMQMAAETNLKKVSLELGGKSALIVCQDADLEEAAQVATTGFCFNTGQVCTA SSRIYAHESVYDEFVSRLRKNVEAQRVGPGNDTANNMGPLVSQKQYERVLMYIEDGVKAG ATVVTGGKKVGGKGYFVQPTIFSDVKEDMRICNEEIFGPVTCVMKFKDMDEVVKRANKSI YGLAAGICTRSMDTALRYSTYLHAGTVWVNTWNNFCVSMPFGGFKRSGIGRELGNEVIDM YTETKAIHFALKGPIVKP |
| DNA Sequence | >LmjF25.1120 |ALDH2||aldehyde dehydrogenase, mitochondrial precursor|Leishmania major|chr 25|||Manual ATGCTGCGCG CCACTCTCAC TCGCCTGGAG ATGGCCCCCA AGGTCATCCA CATCCAGGACAAGTTGCTGA TCAACGGCAA GTTCGTGCCG GCGGTGTCTG GTAAGACATT CGAGGTTGTGAACCCCGCGA ATGAAGAGGT AATCGCGAAC GTCGCGGAGG CCGAAACGGC AGACGTGAACCTTGCTGTGA ATGCTGCCCG CCATGCCTTC GAGTCCTTCC GCATGACCGA CGGCCACTGGCGCCGCAATC TGATGCTGCG CTTGGCGGAC ATCCTGGAGA AGAACAGCAA AGAGATGGCTGCGCTGGAGA GCCTGGACAA CGGCAAGCCG TACGAGGTGG CGCTGAACGT GGACGTGGCGCTGTCGGTGG AGTGCTTCCG GTACTGCGCT GGACTCGCGG ACAAGGTGAA TGGCACCGTGCCGCCGCGCT CCGGTAACTT CCTCGGCATT GTGAAACGTG AGCCGATCGG CGTGTGCGGCCAGATCATCC CGTGGAACTT CCCGCTTCTG ATGGCTGCGT TCAAGCTCAG CCCTGCGCTCGCATTGGGCA ACACGGTTGT ACTGAAGCCC GCGGAGCAGA CGCCGCTGAG TGTGCTGTGTCTTGGCGAGA TGGCGATGGA GGCTGGCTAC CCGAACGGTG TGCTGAACAT CTTGCCGGGCTTCGGCGCGA CCGCAGGCGC GGATATTGCG CGCCACATGG ACGTGGACAA GGTTGCCTTTACGGGCTCGA CAGCTGTCGG CCATCAGGTG ATGCAGATGG CGGCAGAGAC CAACTTGAAGAAGGTGTCTC TGGAGCTTGG CGGCAAGTCT GCGCTGATCG TGTGCCAGGA CGCCGACTTGGAGGAGGCGG CGCAGGTCGC GACGACCGGT TTCTGCTTCA ACACGGGCCA GGTGTGCACGGCGTCGTCGC GCATTTACGC GCACGAGTCC GTGTACGACG AGTTCGTCTC GCGTCTGCGAAAGAACGTGG AGGCGCAGAG GGTGGGACCA GGCAACGACA CGGCGAACAA CATGGGCCCATTGGTGTCGC AGAAGCAGTA CGAGCGGGTG CTCATGTACA TCGAGGACGG CGTGAAGGCTGGCGCGACGG TGGTGACTGG CGGCAAGAAG GTCGGCGGCA AGGGCTATTT CGTGCAGCCGACCATATTTT CGGACGTGAA GGAGGACATG CGGATCTGCA ACGAGGAGAT CTTTGGCCCCGTGACGTGCG TGATGAAGTT CAAGGACATG GACGAGGTTG TGAAGCGCGC GAACAAGAGTATCTACGGGC TGGCTGCTGG CATCTGTACG CGCAGCATGG ACACTGCGCT CCGCTATTCGACATACCTCC ACGCCGGCAC GGTGTGGGTG AACACCTGGA ACAATTTCTG CGTCTCCATGCCGTTTGGCG GATTCAAGCG GAGCGGCATT GGTCGGGAGC TGGGCAACGA AGTCATCGACATGTACACGG AGACGAAGGC GATCCACTTT GCCCTCAAGG GGCCCATTGT CAAGCCGTGA |
| Aldehyde dehydrogenase, mitochondrial Q4Q9Y1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | oxidoreductase activity |
| Biochemical Pathway | metabolism |
| Regulatory Pathway | |
| KEGG Pathways | K00128 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | aldehyde dehydrogenase 1B1 precursor [Homo sapiens] | 46 | 1e-118 | 421 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| gbsA Glycine betaine aldehyde dehydrogenase gbsA | Staphylococcus aureus | 35% | 4e-77 | 283 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00068 | Aldehyde dehydrogenases active sites | 264-271; | PS00687 | |
| Acylation | N-myristoylation site | 145-150; 222-227; 226-231; 267-272; 296-301; 331-336; 357-362; 423-428; | PS00008 | |
| Amidation | Amidation site | 367-370; | PS00009 | |
| Glycosylation | N-glycosylation site | 137-140; 332-335; 418-421; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 260-263; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 7-10; 310-313; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 33-35; 72-74; 302-304; 343-345; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 305-319; 475-489; | PS00003 | |
| Aldehyde dehydrogenase, mitochondrial [Q4Q9Y1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1bxsD | |
| Percent Identity | 46% | |
| Target Region | 1-502 | |
| Template Region | 7-494 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 189 | Sidechain |
| GLU | 265 | Sidechain |
| CYS | 299 | Sidechain |
| GLU | 396 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 663.425 | C21 H27 N7 O14 P2 | c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N | 1bxs | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/810360/Q4Q9Y1.pdb 2.0 499 = residues | | = | *| Ramachandran plot: 92.4% core 7.1% allow 0.2% gener 0.2% = disall | | = | +| All Ramachandrans: 13 labelled residues (out of 497) = | +| Chi1-chi2 plots: 2 labelled residues (out of 272) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 19.3 Bad contacts: = 5 | *| Bond len/angle: 6.3 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.07 Covalent: -0.09 Overall: = 0.01 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 95.3% within limits 4.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |