| GTP-binding protein, putative [Q4Q9V1] | |
|---|---|
| Systematic Name | LmjF.25.1420 [Leishmania major] |
| Gene Name | LMJF_25_1420 |
| Molecular Weight | 24224 Da |
| Protein Sequence Size | 216 |
| Function | |
| Charge | 0 |
| Isoelectric Point | 6.5055 pH |
| Description | GTP-binding protein, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q9V1|Q4Q9V1_LEIMA GTP-binding protein, putative - Leishmania major QQAPSDCVASFKLILVGDGGTGKTTFVKRHLTGEFEKRYVATVGVDVHPLTFHTNRGKIC FNCWDTAGQEKFGGLRDGYYVEGQCAIIMFDVTSRNTYKNVPNWYRDITRVCDNIPIVLV GNKVDCADRQVKAKMITFHRKKGLQYYDISAKSNYNFEKPFVWLAKKLANDPELMLVEVP MLDTDVVALTAEQVAALEAEQQAMANAPLPMGDDE |
| DNA Sequence | >LmjF25.1420 |||GTP-binding protein, putative|Leishmania major|chr 25|||Manual ATGCAACAGG CACCCTCGGA CTGCGTTGCC AGCTTCAAGC TGATCCTGGT CGGCGACGGTGGCACGGGTA AGACGACTTT CGTGAAGCGT CACCTGACCG GCGAGTTCGA GAAGCGCTACGTCGCCACCG TTGGCGTCGA TGTGCACCCG CTGACCTTCC ACACGAACCG TGGCAAGATCTGCTTCAACT GCTGGGATAC TGCCGGCCAG GAGAAGTTCG GTGGTCTGCG CGATGGCTACTACGTGGAAG GCCAGTGCGC CATCATCATG TTTGATGTCA CGAGCCGCAA CACGTACAAGAACGTGCCGA ACTGGTACCG CGACATCACA CGCGTGTGCG ACAACATTCC CATCGTCTTGGTAGGCAACA AGGTAGACTG CGCGGACCGT CAGGTGAAGG CGAAGATGAT CACCTTCCACCGCAAGAAGG GCCTGCAGTA CTACGATATC TCGGCCAAGT CGAACTACAA CTTTGAGAAGCCGTTCGTGT GGCTGGCGAA GAAGCTCGCC AACGATCCCG AGCTGATGCT GGTGGAGGTGCCGATGCTGG ACACAGATGT GGTTGCTCTT ACGGCAGAGC AGGTGGCCGC GCTGGAGGCGGAGCAGCAGG CCATGGCGAA CGCGCCGCTG CCCATGGGCG ATGACGAGTG A |
| GTP-binding protein, putative Q4Q9V1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | GTP binding; GTPase activity |
| Biochemical Pathway | intracellular protein transport; protein transport; small GTPase mediated signal transduction |
| Regulatory Pathway | |
| KEGG Pathways | K07936 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | ras-related nuclear protein [Homo sapiens] | 80 | 1e-81 | 299 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YLR293c GTP-binding protein of the ras superfamily | Saccharomyces cerevisiae | 68% | 2e-81 | 295 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 18-25; | PS00017 | |
| Acylation | N-myristoylation site | 21-26; 75-80; | PS00008 | |
| Phosphorylation | Protein kinase C phosphorylation site | 11-13; 22-24; 55-57; 94-96; 98-100; 151-153; | PS00005 | |
| Prenylation | GTP-binding nuclear protein ran signature | 66-81; | PS01115 | |
| GTP-binding protein, putative [Q4Q9V1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1rrpC | |
| Percent Identity | 80% | |
| Target Region | 9-188 | |
| Template Region | 8-180 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| GLN | 62 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 522.196 | C10 H17 N6 O13 P3 | O=P(O)(O)NP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O | 1rrp | |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1rrp |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
|
|
|
| Modeled Protein | Template Structure |
|
|
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2321886/Q4Q9V1.pdb 2.0 180 = residues | | = | *| Ramachandran plot: 86.7% core 10.1% allow 1.9% gener 1.3% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 178) = | +| Chi1-chi2 plots: 1 labelled residues (out of 109) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 5 | *| Bond len/angle: 5.8 Morris et al class: 1 = 1 3 | | = | | G-factors Dihedrals: -0.09 Covalent: -0.11 Overall: = -0.09 | | = | | M/c bond lengths: 99.3% within limits 0.7% highlighted = | | M/c bond angles: 94.5% within limits 5.5% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |