| Succinyl-CoA synthetase alpha subunit, putative [Q4Q9M4] | |
|---|---|
| Systematic Name | LmjF.25.2130 [Leishmania major] |
| Gene Name | LMJF_25_2130 |
| Molecular Weight | 30912 Da |
| Protein Sequence Size | 299 |
| Function | |
| Charge | 10 |
| Isoelectric Point | 9.4804 pH |
| Description | Succinyl-CoA synthetase alpha subunit, putative (EC 6.2.1.4). |
| Subcellular Location | Mitochondrion[Predict] |
| E. C. Number | 6.2.1.4 |
| Sequence | >tr|Q4Q9M4|Q4Q9M4_LEIMA Succinyl-CoA synthetase alpha subunit, putative (EC 6.2.1.4) - Leishmania major. FARSAIRRWVNKDTKVIVQGMTGKAGTFHTKEAMAYGTKVVGGVSPKKAGTTALGVPVFA TAAEAVKATGATASVLYVPAPLCAASIEEALDAELPLVVVITEGIPQWDMLRVKSMLLSQ NKTRLIGPNCPGIIKPAECKIGIMPGHIHQKGKIGIVSRSGTLTYEAVAQTTAEGLGQSL CVGIGGDPFNGTNMVDCLRLFLNDPETEGIILIGEIGGTAEEEAADFIKNSPIKKPIVSF IGGATAPPGRRMGHAGAIVSGGMGTAKGKKDALRAAGVTISDSPAHLGKHMAELFATK |
| DNA Sequence | >LmjF25.2130 |||succinyl-CoA synthetase alpha subunit, putative|Leishmania major|chr 25|||Manual ATGTTCGCCC GCTCCGCCAT CCGCCGCTGG GTCAACAAGG ACACGAAGGT GATTGTCCAGGGCATGACTG GCAAGGCCGG CACGTTCCAC ACGAAGGAGG CGATGGCGTA CGGCACCAAGGTCGTGGGCG GCGTGAGCCC GAAGAAGGCG GGCACGACGG CGCTGGGCGT GCCGGTGTTTGCGACGGCTG CGGAGGCGGT GAAGGCGACG GGCGCGACTG CGTCGGTGCT GTACGTGCCTGCGCCTTTGT GCGCTGCGTC GATCGAGGAG GCTCTGGACG CGGAGCTGCC GCTGGTTGTAGTGATCACGG AGGGCATCCC GCAGTGGGAC ATGCTGCGCG TGAAGTCGAT GCTGCTGTCGCAGAACAAGA CACGCCTGAT CGGCCCCAAC TGCCCAGGCA TCATCAAGCC TGCGGAGTGCAAGATCGGCA TCATGCCCGG TCACATCCAC CAGAAGGGCA AGATCGGCAT TGTGTCGCGCAGCGGCACGC TGACGTATGA GGCGGTTGCG CAGACGACGG CGGAGGGCCT CGGCCAGTCGCTGTGCGTCG GCATTGGCGG CGACCCGTTC AACGGCACAA ACATGGTGGA CTGCCTGAGGCTGTTTCTGA ATGACCCCGA GACGGAGGGC ATCATACTGA TTGGCGAGAT CGGCGGCACCGCGGAGGAGG AAGCGGCAGA CTTCATCAAG AACAGCCCGA TCAAGAAGCC GATCGTGTCCTTCATCGGCG GGGCGACTGC GCCGCCGGGC CGCCGCATGG GCCACGCCGG TGCTATCGTGTCTGGCGGGA TGGGCACCGC GAAGGGCAAG AAGGATGCGC TGCGCGCCGC CGGCGTGACCATCTCCGACT CGCCGGCGCA CCTTGGCAAG CACATGGCTG AGCTCTTCGC CACGAAGTAG |
| Succinyl-CoA synthetase alpha subunit, putative Q4Q9M4] | |
|---|---|
| Metabolite Information | |
| Molecular Function | catalytic activity |
| Biochemical Pathway | metabolism; tricarboxylic acid cycle |
| Regulatory Pathway | |
| KEGG Pathways | K01902 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | succinate-CoA ligase, GDP-forming, alpha subunit [Homo sapiens] | 61 | 5e-97 | 351 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| sucD succinyl-CoA synthetase alpha subunit | Mycobacterium tuberculosis H37Rv | 42% | 1e-59 | 223 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00335 | ATP-citrate lyase / succinyl-CoA ligases signatures | 244-257; | PS00399 | |
| PDOC00335 | ATP-citrate lyase / succinyl-CoA ligases signatures | 159-188; | PS01216 | |
| Acylation | N-myristoylation site | 27-32; 71-76; 143-148; 176-181; 178-183; 257-262; 262-267; 263-268; 265-270; 278-283; | PS00008 | |
| Amidation | Amidation site | 249-252; 268-271; | PS00009 | |
| Glycosylation | N-glycosylation site | 122-125; 191-194; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 62-65; 87-90; 172-175; 220-223; 280-283; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 23-25; 46-48; 266-268; | PS00005 | |
| Succinyl-CoA synthetase alpha subunit, putative [Q4Q9M4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2fppA | |
| Percent Identity | 62% | |
| Target Region | 1-299 | |
| Template Region | 2-304 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| GLU | 216 | Unknown |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16887-00-6 | CHLORIDE ION | 35.453 | Cl | [Cl-] | 2fpp |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S | [O-]S([O-])(=O)=O | 2fpp |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/5128015/Q4Q9M4.pdb 2.0 299 = residues | | = | +| Ramachandran plot: 91.7% core 7.4% allow 0.8% gener 0.0% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 297) = | +| Chi1-chi2 plots: 1 labelled residues (out of 143) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.2 Bad contacts: = 1 | *| Bond len/angle: 6.2 Morris et al class: 1 = 1 2 | +| 2 cis-peptides = | | G-factors Dihedrals: 0.05 Covalent: -0.15 Overall: = -0.03 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 95.3% within limits 4.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |