| Silent information regulator 2, putative [Q4Q9H0] | |
|---|---|
| Systematic Name | LmjF.26.0210 [Leishmania major] |
| Gene Name | Sir2 |
| Molecular Weight | 40554 Da |
| Protein Sequence Size | 373 |
| Function | |
| Charge | -8 |
| Isoelectric Point | 5.3 pH |
| Description | Silent information regulator 2, putative (Nad-dependent sir2, putative) (EC 3.5.1.-). |
| Subcellular Location | chromatin silencing complex[Predict] |
| E. C. Number | 3.5.1.- |
| Sequence | >tr|Q4Q9H0|Q4Q9H0_LEIMA Silent information regulator 2, putative (Nad-dependent sir2, putative) (EC 3.5.1.-) - Leishmania major. TGSPRAPHQEHALGEPTVEGLARYIREKDVRRILVLVGAGASVAAGIPDFRSSDTGIYAK LGKYNLDDPTDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVHHFIRLLQDEGRLLRC CTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNYLEAMSGTVSRCSTCGG IVKPNVVFFGENLPDAFFDALHHDAPIAELVIIIGTSMQVHPFALLPCVVPKSIPRVLMN RERVGGLLFRFPDDPLDTIHDDAVAKEGRSSSSQSRSPSASARREEGGTEDGSSSPNEEV EDASTSSSSDGYGQYGDYYAHPDVCRDVFFRGDCQENVLKLAECLGLREALAKRMRFSGA APATARKTSNET |
| DNA Sequence | >LmjF26.0210 |SIR2||silent information regulator 2, putative|Leishmania major|chr 26|||Manual ATGACAGGGT CTCCGAGAGC GCCGCATCAG GAACATGCCC TCGGAGAGCC GACTGTGGAAGGGCTTGCGC GCTACATCAG GGAGAAGGAT GTGCGGCGCA TTCTCGTGCT CGTCGGAGCAGGCGCCAGCG TAGCTGCCGG CATCCCAGAC TTTCGCTCAT CTGACACCGG GATCTACGCCAAGCTCGGCA AGTACAACCT CGACGACCCG ACCGATGCCT TTTCGCTGAC TCTTCTGCGCGAGAAGCCAG AGATATTCTA CTCTATCGCA CGGGAGCTGA ACTTGTGGCC TGGGCACTTTCAGCCCACCG CGGTGCATCA CTTCATCCGA CTGTTGCAAG ACGAGGGCCG TCTTCTGCGCTGCTGCACGC AGAACATTGA TGGTCTGGAG AAGGCAGCGG GCGTGTCGCC GGAGCTCCTGGTCGAGGCGC ATGGGTCTTT CGCTGCCGCC GCCTGCATCG AATGCCACAC GCCATTCAGCATTGAGCAGA ACTACCTGGA GGCGATGAGC GGCACGGTGT CCCGCTGCTC TACATGCGGCGGCATTGTGA AGCCAAACGT CGTTTTCTTT GGTGAAAATT TGCCGGACGC GTTCTTCGACGCGCTGCACC ACGACGCCCC GATCGCGGAG CTGGTCATCA TCATCGGGAC ATCGATGCAGGTGCACCCGT TCGCGTTACT GCCGTGCGTC GTGCCCAAGT CCATCCCGCG CGTTCTCATGAACCGCGAGC GAGTTGGCGG CCTCCTCTTC CGCTTTCCTG ATGACCCGCT CGACACCATCCACGACGATG CGGTTGCCAA GGAGGGACGC TCGTCCTCTT CGCAGAGCCG TTCCCCGTCCGCGTCGGCGC GGCGCGAGGA GGGGGGGACG GAGGACGGCT CCTCGTCGCC GAACGAGGAGGTCGAAGACG CGTCGACGTC CAGTTCGAGT GACGGCTACG GTCAGTACGG TGACTACTACGCCCACCCCG ATGTCTGCCG GGATGTTTTC TTCCGCGGCG ACTGCCAGGA GAACGTGCTGAAGCTGGCCG AGTGCCTGGG CCTCAGGGAG GCGCTGGCCA AGCGCATGCG CTTCTCCGGTGCGGCACCAG CTACGGCACG AAAGACGTCG AATGAGACGT GA |
| Silent information regulator 2, putative Q4Q9H0] | |
|---|---|
| Metabolite Information | |
| Molecular Function | DNA binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity |
| Biochemical Pathway | DNA repair; chromatin silencing; regulation of transcription, DNA-dependent |
| Regulatory Pathway | |
| KEGG Pathways | K01463 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | sirtuin 2 isoform 2 [Homo sapiens] | 42 | 2e-51 | 200 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| Rv2260 hypothetical protein | Mycobacterium tuberculosis H37Rv | 40% | 5.5 | 26.2 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 332-334; | PS00016 | |
| PDOC50305 | Sirtuin catalytic domain profile | 49.273 | 20-351 | PS50305 |
| Acylation | N-myristoylation site | 39-44; 41-46; 128-133; 145-150; 289-294; 347-352; 360-365; | PS00008 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 367-370; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 259-262; 296-299; 308-311; 369-372; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 4-6; 282-284; 365-367; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 52-59; 80-87; | PS00007 | |
| Silent information regulator 2, putative [Q4Q9H0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1j8fC | |
| Percent Identity | 42% | |
| Target Region | 9-367 | |
| Template Region | 54-301 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 23713-49-7 | ZINC ION | 65.409 | Zn | [Zn+2] | 1j8f |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1438704/Q4Q9H0.pdb 2.0 357 = residues | | = | *| Ramachandran plot: 93.1% core 4.9% allow 1.3% gener 0.7% = disall | | = | +| All Ramachandrans: 9 labelled residues (out of 355) = | +| Chi1-chi2 plots: 2 labelled residues (out of 195) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 4 | *| Bond len/angle: 7.6 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.06 Covalent: -0.20 Overall: = -0.04 | | = | | M/c bond lengths: 98.9% within limits 1.1% highlighted = | | M/c bond angles: 93.4% within limits 6.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |