| Glutathione peroxidase-like protein, putative [Q4Q9B4] | |
|---|---|
| Systematic Name | LmjF.26.0800 [Leishmania major] |
| Gene Name | TDPX |
| Molecular Weight | 20214 Da |
| Protein Sequence Size | 183 |
| Function | Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione |
| Charge | 8 |
| Isoelectric Point | 8.4 pH |
| Description | Glutathione peroxidase-like protein, putative (EC 1.11.1.9). |
| Subcellular Location | cytosol; glycosome; Mitochondrion[Predict] |
| E. C. Number | 1.11.1.9 |
| Sequence | >tr|Q4Q9B4|Q4Q9B4_LEIMA Glutathione peroxidase-like protein, putative (EC 1.11.1.9) - Leishmania major LRLPPFPRAAAAAQASSIYDFKVNGSDHQPYDLGQHKGHPLLIYNVASKCGFTKGGYETA TALYNKYKHLGFMVLAFPCNQFAGQEPGTEEEVKSFACTRFKAEFPIMEKVCVNGEHEHP LYHYLKNTCKGILGTTLVKWNFTAFLVDKDGHAVCRFAPGATVSEIEKKLLPLLQAAASS KI |
| DNA Sequence | >LmjF26.0800 |TDBX||type II (glutathione peroxidase-like) tryparedoxin peroxidase|Leishmania major|chr 26|||Manual ATGCTGCGCT TGCCACCTTT TCCCCGCGCC GCCGCTGCGG CACAGGCGTC TTCTATCTACGACTTCAAGG TCAATGGCAG CGACCACCAG CCATACGACC TTGGCCAGCA CAAGGGGCACCCGCTTCTCA TCTACAACGT AGCCAGCAAG TGCGGCTTCA CCAAGGGCGG CTACGAGACAGCCACGGCGC TATACAACAA GTACAAGCAT CTCGGCTTCA TGGTACTGGC GTTCCCGTGCAACCAGTTCG CCGGTCAGGA GCCTGGAACG GAGGAGGAGG TGAAAAGTTT CGCCTGCACGCGTTTCAAGG CTGAGTTCCC TATTATGGAG AAGGTCTGTG TCAACGGCGA GCACGAGCACCCGCTGTATC ACTACTTGAA GAACACGTGC AAGGGTATTC TCGGCACGAC GCTTGTGAAGTGGAACTTCA CGGCGTTCCT GGTGGACAAG GACGGCCATG CCGTGTGCCG CTTCGCTCCCGGTGCGACGG TGTCCGAAAT CGAGAAGAAG TTGCTGCCGC TACTGCAGGC TGCGGCCTCGTCAAAGATCT GA |
| Glutathione peroxidase-like protein, putative Q4Q9B4] | |
|---|---|
| Metabolite Information | |
| Molecular Function | glutathione peroxidase activity; molecular function unknown |
| Biochemical Pathway | biological process unknown; response to oxidative stress |
| Regulatory Pathway | |
| KEGG Pathways | K00432 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | glutathione peroxidase 4 [Homo sapiens] | 40 | 8e-26 | 113 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| btuE Vitamin B12 transport periplasmic protein btuE | Escherichia coli MG1655 | 39% | 2e-24 | 105 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00396 | Glutathione peroxidases signatures | 39-54; | PS00460 | |
| PDOC00396 | Glutathione peroxidases signatures | 76-83; | PS00763 | |
| PDOC00299 | Microbodies C-terminal targeting signal | 181-183; | PS00342 | |
| Acylation | N-myristoylation site | 35-40; 56-61; 85-90; 132-137; 161-166; | PS00008 | |
| Glycosylation | N-glycosylation site | 25-28; 142-145; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 18-21; 90-93; 163-166; 165-168; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 129-131; 180-182; | PS00005 | |
| Glutathione peroxidase-like protein, putative [Q4Q9B4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2p5rB | |
| Percent Identity | 47% | |
| Target Region | 13-183 | |
| Template Region | 6-164 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| GLU | 74 | Sidechain |
| TRP | 129 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 17787-72-3 | CALCIUM ION | 40.078 | Ca | [Ca+2] | 2p5r |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/424985/Q4Q9B4.pdb 2.0 171 = residues | | = | +| Ramachandran plot: 87.1% core 12.9% allow 0.0% gener 0.0% = disall | | = | *| All Ramachandrans: 6 labelled residues (out of 169) = | | Chi1-chi2 plots: 0 labelled residues (out of 100) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.3 Bad contacts: = 2 | *| Bond len/angle: 6.2 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: -0.06 Covalent: -0.21 Overall: = -0.11 | | = | | M/c bond lengths: 98.7% within limits 1.3% highlighted = | | M/c bond angles: 91.3% within limits 8.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |