| Heat shock protein 70-related protein [Q4Q970] | |
|---|---|
| Systematic Name | LmjF.26.1240 [Leishmania major] |
| Gene Name | HSP70.4 |
| Molecular Weight | 70588 Da |
| Protein Sequence Size | 641 |
| Function | |
| Charge | -17 |
| Isoelectric Point | 4.774 pH |
| Description | Heat shock protein 70-related protein. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q970|Q4Q970_LEIMA Heat shock protein 70-related protein - Leishmania major SSTNAIGIDLGTTYSCVGVFKNEQVDIIANDQGNRTTPSYVAFTETERLIGDAAKNQVAM NPSNTVFDAKRMIGRKFDDPDLQSDMKHWPFKVIVKDGKPVISVEYQNQTKTFFPEEISA MVLQKMKETAEAYLGTTVKDAVITVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAAI AYGMDRKGDKGEKNVLIFDLGGGTFDVTLLTIESGVFEVKATAGDTHLGGEDFDNRLVDY FATELKMRCGKDCRGNARATRRLRTACERVKRTLSSSTTANIEIDALYEGNDFFSKITRA RFEEMCRDQFEKCLEPVKKVLADADMKPQDVDDVVLVGGSTRIPKIQQIVSQFFGGKELN RSINPDEAVAYGAAVQAHILAGGHSSKTDGLLLLDVTPLSLGVETSGGVMSVLIPRNSTM PVQKTQTYSNNADNQRNVVIKVYEGERPLVSQCQCLGTFTLTDIPPMPRGKARINVTFDV NTDGILIVSAVEESGGRKEAITIQNDTGRLSKEQIESMVREAEKFAEEDRMNSERVEARN TLENYTFSMRATLDDPDVQNGITQGDRQQIQDAVNAASSWLEKNREATKEEYMEQTKLIE GIAHPILSEFYKKRVMEAPPSAGPKDGAPSDEVPHAEDVD |
| DNA Sequence | >LmjF26.1240 |HSP70.4||heat shock protein 70-related protein|Leishmania major|chr 26|||Manual ATGTCGTCTA CCAACGCCAT CGGCATCGAC CTGGGCACGA CGTACTCGTG CGTCGGCGTCTTCAAGAACG AGCAGGTGGA CATCATTGCC AACGACCAGG GTAACCGCAC AACGCCGTCTTATGTGGCCT TCACCGAGAC AGAGCGCCTG ATCGGCGATG CCGCGAAGAA CCAGGTGGCCATGAACCCGA GCAACACCGT GTTTGACGCG AAGCGCATGA TCGGCCGCAA GTTCGACGATCCTGACCTTC AGTCGGACAT GAAGCACTGG CCCTTCAAGG TGATCGTCAA GGACGGCAAGCCGGTCATCA GCGTCGAGTA CCAGAACCAG ACCAAGACCT TTTTCCCAGA GGAGATCTCGGCTATGGTGC TGCAGAAAAT GAAGGAGACG GCGGAGGCCT ACCTCGGCAC GACCGTCAAGGACGCCGTCA TCACCGTCCC GGCGTACTTC AACGACTCGC AGCGCCAGGC AACGAAGGACGCCGGCTCCA TCGCTGGCCT CAACGTGCTG CGCATCATCA ACGAGCCCAC CGCCGCCGCTATCGCGTACG GCATGGACCG CAAGGGAGAC AAGGGGGAGA AGAATGTGCT CATCTTCGACCTTGGCGGCG GCACGTTCGA TGTGACGCTG CTGACGATCG AGTCCGGCGT GTTCGAGGTAAAGGCAACCG CGGGTGACAC GCACCTTGGC GGCGAGGACT TCGACAACCG TCTCGTCGACTACTTCGCCA CTGAGCTCAA GATGCGCTGC GGCAAGGACT GCCGTGGCAA CGCCCGCGCCACGCGCCGTC TGCGCACGGC GTGCGAGCGC GTGAAGCGCA CGCTGTCCAG CTCCACGACGGCAAACATCG AGATTGACGC GCTGTACGAG GGCAATGACT TCTTCTCGAA GATCACGCGCGCGCGCTTCG AGGAGATGTG CCGCGATCAG TTTGAGAAGT GCCTCGAGCC GGTGAAAAAGGTGCTGGCAG ATGCGGATAT GAAGCCGCAG GACGTGGACG ACGTCGTCCT CGTCGGCGGATCGACCCGAA TCCCAAAGAT CCAGCAGATT GTCTCGCAGT TCTTCGGCGG CAAGGAGCTGAACCGCTCCA TCAACCCCGA TGAGGCCGTT GCGTACGGTG CGGCGGTGCA GGCGCACATTCTCGCCGGCG GTCATTCCTC TAAGACTGAC GGGCTGCTGC TGCTTGACGT GACGCCGCTCTCGCTCGGTG TGGAGACATC CGGCGGTGTC ATGTCCGTGC TCATCCCGCG CAACTCGACGATGCCGGTGC AAAAGACGCA GACATACTCG AACAACGCCG ATAATCAGCG TAACGTGGTGATCAAGGTGT ACGAAGGCGA GCGTCCGCTG GTTTCGCAGT GTCAGTGCCT CGGCACCTTCACGCTGACCG ACATCCCACC CATGCCGCGC GGCAAGGCGC GCATCAACGT CACGTTCGACGTGAACACGG ACGGCATCCT CATCGTGAGC GCCGTCGAGG AGTCGGGTGG TCGAAAGGAGGCCATCACGA TCCAGAACGA CACGGGCCGT CTGAGCAAGG AGCAGATCGA GAGCATGGTGCGGGAGGCCG AAAAGTTTGC TGAGGAGGAC AGGATGAACA GCGAGCGCGT CGAGGCACGCAACACGCTGG AAAACTACAC CTTCTCCATG CGCGCCACCC TAGACGACCC GGATGTGCAGAATGGAATCA CGCAGGGGGA CCGCCAGCAA ATCCAGGACG CCGTCAACGC TGCCTCGAGCTGGCTTGAGA AAAACCGGGA GGCCACCAAG GAGGAGTACA TGGAGCAGAC GAAGCTGATCGAGGGCATCG CGCACCCGAT TTTGTCGGAG TTCTACAAAA AGCGTGTCAT GGAGGCCCCACCAAGCGCTG GGCCGAAGGA CGGTGCCCCC TCAGATGAGG TGCCCCACGC CGAAGACGTTGACTAA |
| Heat shock protein 70-related protein Q4Q970] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; molecular function unknown |
| Biochemical Pathway | protein folding |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | heat shock 70kDa protein 8 isoform 1 [Homo sapiens] | 62 | 0 | 800 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YJL034w nuclear fusion protein | Saccharomyces cerevisiae | 55% | 0 | 657 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 9-16; | PS00297 | |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 198-211; | PS00329 | |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 335-349; | PS01036 | |
| Acylation | N-myristoylation site | 8-13; 12-17; 19-24; 162-167; 256-261; 383-388; 403-408; 408-413; 562-567; | PS00008 | |
| Amidation | Amidation site | 74-77; 496-499; | PS00009 | |
| Glycosylation | N-glycosylation site | 35-38; 109-112; 151-154; 361-364; 418-421; 476-479; 506-509; 545-548; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 45-48; 66-69; 138-141; 223-226; 266-269; 387-390; 461-464; 490-493; 553-556; 564-567; 580-583; 589-592; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 47-49; 138-140; 153-155; 261-263; 341-343; 386-388; 508-510; 534-536; 549-551; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 282-296; | PS00003 | |
| Heat shock protein 70-related protein [Q4Q970] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1yuwA | |
| Percent Identity | 67% | |
| Target Region | 1-555 | |
| Template Region | 1-554 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 71 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
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| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2486505/Q4Q970.pdb 2.0 555 = residues | | = | *| Ramachandran plot: 92.1% core 7.3% allow 0.4% gener 0.2% = disall | | = | +| All Ramachandrans: 13 labelled residues (out of 553) = | +| Chi1-chi2 plots: 2 labelled residues (out of 321) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 6.5 Bad contacts: = 6 | *| Bond len/angle: 8.0 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.08 Covalent: -0.10 Overall: = 0.01 | | = | | M/c bond lengths: 99.7% within limits 0.3% highlighted = | | M/c bond angles: 95.3% within limits 4.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |