| 6-phosphogluconolactonase [Q4Q8S1] | |
|---|---|
| Systematic Name | LmjF.26.2700 [Leishmania major] |
| Gene Name | LMJF_26_2700 |
| Molecular Weight | 28444 Da |
| Protein Sequence Size | 267 |
| Function | |
| Charge | -4 |
| Isoelectric Point | 5.6 pH |
| Description | 6-phosphogluconolactonase (EC 3.1.1.17). |
| Subcellular Location | cytoplasm[Predict] |
| E. C. Number | 3.1.1.17 |
| Sequence | >tr|Q4Q8S1|Q4Q8S1_LEIMA 6-phosphogluconolactonase (EC 3.1.1.17) - Leishmania major SSFAPNVKICEDISHISSAARDIILAAIDARVDKSAPVVLALSGGSTPKRLYEELHEKDL TLLQQHAVQFILGDERLVATDDEQSNFSMATKALLRDVPISDVIAIEPSAALATSKDEKG GVDGAWAVAQDYEKKLRNRLPCTQVNGTDMSVPIVDIVLLGFGADGHTASIFPDSVAATD ESHVVSVSFPSPTMNPKVWRVTLSKTVIQHAKHVVVLACGKDKNWVVHGVLAEAPTGPLP VSRFLRECRGSVTMLLDAGSGEGLSA |
| DNA Sequence | >LmjF26.2700 |||6-phosphogluconolactonase|Leishmania major|chr 26|||Manual ATGAGTTCCT TCGCGCCCAA CGTGAAGATT TGCGAGGACA TTTCCCACAT AAGTTCCGCCGCGCGCGACA TCATCCTCGC CGCGATCGAC GCGCGCGTAG ATAAGTCTGC CCCTGTTGTGCTGGCGCTGT CTGGAGGCTC CACCCCTAAG CGGCTGTACG AGGAGCTCCA CGAAAAGGATCTGACTCTGC TGCAGCAGCA CGCGGTGCAG TTCATTCTGG GCGATGAGCG CCTCGTCGCGACAGACGATG AGCAGAGCAA CTTCTCCATG GCGACGAAAG CGCTGCTGCG TGATGTGCCCATCAGCGATG TCATCGCAAT CGAGCCGAGC GCCGCGCTAG CCACGTCGAA GGACGAGAAGGGTGGTGTTG ACGGTGCGTG GGCTGTCGCA CAGGATTATG AGAAGAAGCT CCGGAATCGCCTGCCGTGCA CGCAAGTAAA CGGTACAGAT ATGTCTGTTC CTATAGTGGA TATTGTGCTTCTCGGATTCG GCGCAGACGG CCATACCGCC TCCATCTTTC CCGACTCCGT GGCGGCCACGGATGAGAGCC ACGTCGTCTC GGTCAGCTTT CCCAGCCCGA CCATGAACCC CAAGGTCTGGCGTGTCACGC TCTCAAAGAC TGTGATTCAG CACGCCAAGC ACGTTGTCGT GCTCGCCTGCGGCAAGGACA AAAACTGGGT CGTGCACGGT GTGCTCGCGG AGGCGCCGAC GGGTCCTCTGCCAGTATCGC GGTTTCTGAG AGAGTGCCGC GGGTCTGTTA CGATGCTTCT CGATGCCGGCTCGGGTGAGG GCCTCTCTGC ATAG |
| 6-phosphogluconolactonase Q4Q8S1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | 6-phosphogluconolactonase activity |
| Biochemical Pathway | carbohydrate metabolism; pentose-phosphate shunt |
| Regulatory Pathway | |
| KEGG Pathways | K01057 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | 6-phosphogluconolactonase [Homo sapiens] | 30 | 1e-17 | 87 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| HP1102 glucose-6-phosphate 1-dehydrogenase (devB) | Helicobacter pylori | 23% | 0.00000006 | 52 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 121-126; 122-127; 148-153; 260-265; | PS00008 | |
| Glycosylation | N-glycosylation site | 87-90; 147-150; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 81-84; 115-118; 116-119; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 48-50; 115-117; | PS00005 | |
| 6-phosphogluconolactonase [Q4Q8S1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2j0eB | |
| Percent Identity | 48% | |
| Target Region | 1-270 | |
| Template Region | 2-263 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7439-97-6 | MERCURY (II) ION | 200.59 | Hg | [Hg+2] | 2j0e |
| 24203-36-9 | POTASSIUM ION | 39.098 | K | [K+] | 2j0e |
| 23713-49-7 | ZINC ION | 65.409 | Zn | [Zn+2] | 2j0e |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/319292/Q4Q8S1.pdb 2.0 267 = residues | | = | *| Ramachandran plot: 91.5% core 7.3% allow 0.4% gener 0.9% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 265) = | +| Chi1-chi2 plots: 3 labelled residues (out of 135) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 2 | *| Bond len/angle: 8.6 Morris et al class: 1 = 1 2 | +| 2 cis-peptides = | | G-factors Dihedrals: 0.04 Covalent: -0.20 Overall: = -0.05 | | = | *| M/c bond lengths: 98.6% within limits 1.4% highlighted 1 off = graph | | M/c bond angles: 93.5% within limits 6.5% highlighted = | +| Planar groups: 98.7% within limits 1.3% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |