| Proteasome subunit beta type [Q4Q8Q9] | |
|---|---|
| Systematic Name | LmjF.28.0110 [Leishmania major] |
| Gene Name | LMJF_28_0110 |
| Molecular Weight | 22463 Da |
| Protein Sequence Size | 205 |
| Function | |
| Charge | -3 |
| Isoelectric Point | 5.1 pH |
| Description | Proteasome subunit beta type. |
| Subcellular Location | proteasome core complex (sensu Eukaryota); proteasome core complex, beta-subunit complex (sensu Eukaryota)[Predict] |
| E. C. Number | 3.4.25.1 |
| Sequence | >tr|Q4Q8Q9|Q4Q8Q9_LEIMA Proteasome subunit beta type - Leishmania major SIMSYSGGSVMAMAGKECFVIISDKRLGEQLKTISTEVPKLHVVNNSIVYGLTGLRTDQQ TFANKVQFRTDMYKLREERDITGKAFAAMITSMLYEARFGPWFVEPVIGSIDKSTGEVYL CATDLIGAPCEPEDYVCAGTAAESLHGMCEALWRPGMSPEEVFEIAAQAMLSACDRDSLS GYGAVAMIVTKDKITTRLIKGRKD |
| DNA Sequence | >LmjF28.0110 |||proteasome beta 3 subunit, putative|Leishmania major|chr 28|||Manual ATGTCTATTA TGTCATACAG CGGTGGCTCG GTGATGGCCA TGGCGGGAAA GGAGTGCTTCGTCATCATCT CCGATAAACG CCTCGGCGAG CAGCTGAAGA CTATCTCGAC GGAGGTGCCCAAGCTGCATG TTGTTAACAA CAGCATCGTG TACGGCCTCA CCGGTCTGCG CACGGACCAGCAAACCTTTG CGAACAAAGT TCAGTTTCGC ACCGACATGT ACAAGCTGCG CGAGGAGCGCGACATCACTG GCAAGGCGTT CGCGGCGATG ATCACGTCCA TGCTGTACGA GGCACGTTTCGGACCATGGT TCGTGGAGCC GGTTATCGGA AGCATAGATA AGTCGACGGG CGAGGTGTACCTGTGCGCCA CCGACCTCAT CGGTGCCCCG TGCGAGCCAG AGGACTATGT GTGCGCCGGCACCGCTGCTG AGAGCTTGCA CGGCATGTGC GAGGCTCTCT GGCGCCCGGG CATGTCTCCGGAGGAGGTTT TCGAGATTGC TGCGCAGGCG ATGCTATCTG CGTGTGATCG CGATAGTCTCTCCGGCTACG GTGCAGTGGC CATGATTGTG ACGAAGGACA AAATCACGAC GCGCCTCATCAAGGGCCGAA AGGACTAG |
| Proteasome subunit beta type Q4Q8Q9] | |
|---|---|
| Metabolite Information | |
| Molecular Function | threonine endopeptidase activity |
| Biochemical Pathway | ubiquitin-dependent protein catabolism |
| Regulatory Pathway | |
| KEGG Pathways | K02735 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | proteasome beta 3 subunit [Homo sapiens] | 47 | 9e-56 | 213 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER094c 20S proteasome subunit (beta3) | Saccharomyces cerevisiae | 43% | 3e-47 | 182 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00668 | Proteasome B-type subunits signature | 12-59; | PS00854 | |
| Acylation | N-myristoylation site | 9-14; 148-153; | PS00008 | |
| Amidation | Amidation site | 201-204; | PS00009 | |
| Glycosylation | N-glycosylation site | 46-49; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 115-118; 141-144; 159-162; 173-176; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 24-26; 83-85; 196-198; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 129-143; | PS00003 | |
| Proteasome subunit beta type [Q4Q8Q9] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1iruX | |
| Percent Identity | 47% | |
| Target Region | 1-205 | |
| Template Region | 2-204 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1iru |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2525146/Q4Q8Q9.pdb 2.0 205 = residues | | = | *| Ramachandran plot: 93.3% core 5.6% allow 0.6% gener 0.6% = disall | | = | +| All Ramachandrans: 6 labelled residues (out of 203) = | +| Chi1-chi2 plots: 2 labelled residues (out of 113) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 4 | *| Bond len/angle: 7.6 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: -0.04 Covalent: -0.12 Overall: = -0.07 | | = | | M/c bond lengths: 99.8% within limits 0.2% highlighted = | | M/c bond angles: 94.4% within limits 5.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |