| Electron-transfer-flavoprotein, alpha polypeptide, putative [Q4Q8F2] | |
|---|---|
| Systematic Name | LmjF.28.1140 [Leishmania major] |
| Gene Name | LMJF_28_1140 |
| Molecular Weight | 33502 Da |
| Protein Sequence Size | 325 |
| Function | |
| Charge | 0.5 |
| Isoelectric Point | 6.7861 pH |
| Description | Electron-transfer-flavoprotein, alpha polypeptide, putative. |
| Subcellular Location | Mitochondrion[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q8F2|Q4Q8F2_LEIMA Electron-transfer-flavoprotein, alpha polypeptide, putative - Leishmania major LRTTALSLGKALVIAEMVGGKVSPATLSAITGAAKVGPVAILVAGASAKDEAQVLAKIKS VASVLVTVGEQYSHGLPEEYAPLIDAAVRANGYTHVFAGTSAFGKNVIPRAAARQSCMPI PEVTEIVDENTFVRQTYAGNAITTIKSSDKIKYCTLRGTAFERAELDGGSAAVADLAATP AVGKAKFVEDQLSTSDKPDLMTAATVISGGRGMKNGDNFKILEELAAPLNAAVGATRAVV DAGYVPNEMQVGQTGKTVAPNFYLACGISGAIQHVAGMKDSKVIAVVNTDEEAPFFQIAD YGIAADLFKVVPALTEKVKAANGK |
| DNA Sequence | >LmjF28.1140 |||electron-transfer-flavoprotein, alpha polypeptide, putative|Leishmania major|chr 28|||Manual ATGCTGCGCA CGACTGCACT CTCACTGGGC AAAGCCCTCG TCATTGCTGA GATGGTGGGTGGGAAGGTCT CACCAGCGAC ACTGTCTGCC ATTACAGGGG CCGCGAAGGT GGGCCCGGTGGCGATCCTGG TGGCCGGTGC GTCCGCCAAG GATGAGGCCC AGGTGCTAGC CAAGATCAAGTCTGTAGCGA GCGTGCTGGT GACGGTCGGG GAGCAATACA GCCACGGCCT CCCGGAGGAGTACGCTCCGC TCATCGACGC GGCGGTGAGG GCGAATGGCT ACACGCACGT GTTTGCCGGGACTTCAGCAT TCGGCAAAAA TGTCATCCCT AGGGCGGCGG CGAGGCAGAG CTGCATGCCCATTCCCGAAG TCACGGAGAT CGTGGACGAG AACACGTTTG TGCGGCAGAC GTACGCCGGCAATGCAATCA CGACCATCAA GTCGTCTGAC AAGATCAAGT ACTGCACCTT GCGCGGTACGGCGTTTGAGC GAGCCGAGTT GGACGGTGGT AGCGCCGCGG TGGCGGACCT CGCCGCAACCCCGGCGGTAG GTAAAGCAAA GTTTGTAGAG GACCAGCTGT CCACCAGCGA CAAGCCCGACTTGATGACGG CGGCGACCGT CATTTCTGGC GGCCGAGGTA TGAAGAACGG CGATAACTTCAAGATTCTGG AGGAGCTGGC CGCCCCGCTG AATGCAGCTG TCGGCGCTAC CCGCGCTGTTGTCGATGCTG GCTACGTGCC AAACGAGATG CAGGTCGGCC AGACGGGCAA GACCGTCGCGCCGAACTTCT ACCTCGCGTG CGGCATCTCC GGCGCTATCC AGCACGTGGC CGGCATGAAGGACTCGAAAG TGATCGCCGT GGTCAACACG GACGAGGAGG CGCCCTTCTT TCAAATCGCCGACTACGGCA TTGCCGCTGA TCTCTTCAAA GTGGTGCCAG CGCTGACGGA GAAGGTGAAGGCGGCTAACG GCAAGTGA |
| Electron-transfer-flavoprotein, alpha polypeptide, putative Q4Q8F2] | |
|---|---|
| Metabolite Information | |
| Molecular Function | electron carrier activity; electron transporter activity |
| Biochemical Pathway | electron transport |
| Regulatory Pathway | |
| KEGG Pathways | K03522 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | electron transfer flavoprotein, alpha polypeptide [Homo sapiens] | 51 | 2e-85 | 312 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| ydiR Putative electron transfer flavoprotein subunit ydiR | Escherichia coli MG1655 | 39% | 4e-23 | 102 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 140-145; 169-174; 213-218; 235-240; 268-273; 278-283; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 48-51; 68-71; 160-163; 194-197; 290-293; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 48-50; 145-147; 149-151; 156-158; 196-198; 255-257; 316-318; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 147-154; 238-245; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 74-88; | PS00003 | |
| Electron-transfer-flavoprotein, alpha polypeptide, putative [Q4Q8F2] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2a1uA | |
| Percent Identity | 51% | |
| Target Region | 1-325 | |
| Template Region | 19-315 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 61-19-8 | ADENOSINE MONOPHOSPHATE  | 347.221 | C10 H14 N5 O7 P   | O=P(O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 2a1u |
| 16426-55-4 | FLAVIN-ADENINE DINUCLEOTIDE | 785.55 | C27 H33 N9 O15 P2 | O=C2C3=Nc1cc(c(cc1N(C3=NC(=O)N2)CC(O)C(O)C(O)COP(=O)(O)OP(=O)(O)OCC6OC(n5cnc4c(ncnc45)N)C(O)C6O)C)C | 2a1u |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/954860/Q4Q8F2.pdb 2.0 325 = residues | | = | +| Ramachandran plot: 93.2% core 6.1% allow 0.7% gener 0.0% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 323) = | +| Chi1-chi2 plots: 2 labelled residues (out of 150) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.9 Bad contacts: = 2 | *| Bond len/angle: 9.6 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.05 Covalent: -0.17 Overall: = -0.03 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | *| M/c bond angles: 93.2% within limits 6.8% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |