| Serine/threonine protein phosphatase [Q4Q7Z5] | |
|---|---|
| Systematic Name | LmjF.28.2670 [Leishmania major] |
| Gene Name | LMJF_28_2670 |
| Molecular Weight | 34669 Da |
| Protein Sequence Size | 307 |
| Function | |
| Charge | -11.5 |
| Isoelectric Point | 4.7244 pH |
| Description | Serine/threonine protein phosphatase (EC 3.1.3.16). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.1.3.16 |
| Sequence | >tr|Q4Q7Z5|Q4Q7Z5_LEIMA Serine/threonine protein phosphatase (EC 3.1.3.16) - Leishmania major SSDLNQQLEAMYEGKLLTEEQVVQLCSRCKDLMLEEGNIETIYAPVTLCGDIHGQFSDLL ELFSKGGRVPETSYVFMGDYVDRGYHSVETLLLLLLLKARYPDRITLLRGNHESRQITQV YGFYDECYRKYGCANVWRLCTELFDYMPLGAVVEEDIFCVHGGLSPQIGTLDEVRVLDRK QEVPHEGPMSDLLWSDPEDIEGWSVSQRGAGFVFGGDVAKSFNHRNGLSLIARAHQLVLE GYKSMFDSNCCTVWSAPNYCYRCGNVASILEVGEHSKTDRNVVYFTAATADVRGHLAKQP PPEYFL |
| DNA Sequence | >LmjF28.2670 |||protein phosphatase 4 catalytic subunit, putative|Leishmania major|chr 28|||Manual ATGTCGAGCG ATTTGAACCA GCAGCTGGAG GCGATGTACG AGGGTAAGCT GCTCACGGAGGAGCAGGTGG TGCAGCTGTG TAGTCGTTGC AAGGACCTCA TGTTAGAGGA GGGCAACATAGAGACCATCT ACGCCCCCGT CACGCTCTGC GGCGACATCC ATGGTCAGTT CTCCGACTTGTTGGAGCTCT TCAGCAAGGG CGGGCGAGTG CCAGAGACGT CGTATGTTTT CATGGGCGACTACGTCGACC GTGGCTACCA CAGTGTGGAG ACGCTGCTGC TGCTACTGCT GCTGAAGGCGCGCTACCCCG ATCGCATCAC GCTGTTGCGT GGTAATCACG AGTCGCGCCA GATTACGCAGGTGTATGGCT TCTACGATGA GTGCTACCGC AAGTACGGCT GCGCGAACGT GTGGCGGCTGTGCACGGAGC TGTTTGACTA CATGCCACTT GGTGCAGTAG TAGAGGAGGA CATCTTTTGTGTGCACGGCG GCCTCAGTCC GCAGATTGGC ACGCTCGATG AAGTGCGTGT GCTGGACCGCAAGCAGGAGG TACCGCACGA GGGCCCCATG AGCGACCTGC TTTGGTCGGA CCCGGAGGACATAGAGGGGT GGAGCGTAAG CCAGCGCGGC GCGGGTTTTG TCTTTGGTGG CGATGTCGCCAAGAGCTTCA ATCACCGAAA CGGTCTCAGT CTCATTGCAC GTGCGCATCA GCTGGTGCTGGAGGGGTACA AGTCGATGTT TGATAGCAAC TGCTGCACGG TGTGGTCAGC CCCAAACTACTGCTACCGGT GTGGTAACGT CGCCTCTATC CTCGAGGTGG GCGAGCACTC CAAGACGGATCGAAACGTTG TGTATTTCAC CGCAGCCACC GCCGATGTGC GCGGCCATCT CGCGAAGCAGCCCCCACCCG AGTACTTCCT GTGA |
| Serine/threonine protein phosphatase Q4Q7Z5] | |
|---|---|
| Metabolite Information | |
| Molecular Function | hydrolase activity |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 4 (formerly X), catalytic subunit [Homo sapiens] | 60 | 1e-113 | 404 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER133w serthr phosphoprotein phosphatase 1, catalytic chain | Saccharomyces cerevisiae | 43% | 7e-67 | 248 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00115 | Serine/threonine specific protein phosphatases signature | 109-114; | PS00125 | |
| Acylation | N-myristoylation site | 38-43; 111-116; 216-221; 265-270; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 171-174; 196-199; 245-248; 269-272; 277-280; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 207-209; 279-281; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 69-75; 139-147; | PS00007 | |
| Serine/threonine protein phosphatase [Q4Q7Z5] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2nppF | |
| Percent Identity | 57% | |
| Target Region | 1-307 | |
| Template Region | 2-308 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 83 | Sidechain |
| ARG | 84 | Sidechain |
| ASN | 112 | Sidechain |
| HIS | 113 | Sidechain |
| ARG | 209 | Sidechain |
| HIS | 236 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 2npp |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/503370/Q4Q7Z5.pdb 2.0 307 = residues | | = | *| Ramachandran plot: 87.6% core 10.5% allow 0.7% gener 1.1% = disall | | = | +| All Ramachandrans: 8 labelled residues (out of 305) = | +| Chi1-chi2 plots: 2 labelled residues (out of 185) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 4 | *| Bond len/angle: 5.8 Morris et al class: 1 = 1 2 | +| 2 cis-peptides = | | G-factors Dihedrals: 0.04 Covalent: -0.12 Overall: = -0.02 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 94.7% within limits 5.3% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |