| Heat-shock protein hsp70, putative [Q4Q7Y4] | |
|---|---|
| Systematic Name | LmjF.28.2770 [Leishmania major] |
| Gene Name | LMJF_28_2770 |
| Molecular Weight | 71653 Da |
| Protein Sequence Size | 658 |
| Function | |
| Charge | -11 |
| Isoelectric Point | 5.0882 pH |
| Description | Heat-shock protein hsp70, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q7Y4|Q4Q7Y4_LEIMA Heat-shock protein hsp70, putative - Leishmania major TFDGAIGIDLGTTYSCVGVWQNERVDIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAM NPHNTVFDAKRLIGRKFNDSVVQSDMKHWPFKVTTKGDDKPVISVQYRGEEKTFTPEEIS SMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTAAA IAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVT FFTEEFKRKNKGKNLASSHRALRRLRTACERAKRTLSSATQATIEIDALFENIDFQATIT RARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKE LNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNT TIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTF DLDANGILNVSAEEKGTGKRNQITITNDKGRLSKDEIERMVNDAMKYEEDDKAQRDRVEA KNGLENYAYSMKNTLSDSNVSGKLDDSDKATLNKEIDAALEWLSSNQEATKEEYEHRQKE LESVCNPIMTKMYQSMGGAAGGMPGGMPGGMPDMSGMSGGAGPAGGASSGPKVEEVD |
| DNA Sequence | >LmjF28.2770 |||heat-shock protein hsp70, putative|Leishmania major|chr 28|||Manual ATGACATTCG ACGGCGCCAT CGGCATCGAC CTGGGCACGA CGTACTCGTG CGTAGGCGTGTGGCAGAACG AACGCGTGGA TATCATCGCG AACGACCAGG GTAACCGCAC GACACCGTCGTACGTTGCGT TCACGGACTC GGAGCGGCTG ATCGGCGATG CTGCAAAGAA CCAGGTGGCAATGAACCCGC ACAACACGGT GTTCGACGCG AAGCGCCTGA TTGGCCGCAA GTTCAACGACTCGGTTGTGC AGTCGGACAT GAAGCACTGG CCGTTCAAGG TGACGACGAA GGGTGACGACAAGCCCGTGA TTTCGGTGCA GTACCGCGGC GAGGAGAAGA CCTTCACGCC GGAGGAGATCAGCTCGATGG TGCTGCTGAA GATGAAGGAG ACGGCGGAGG CGTACCTGGG CAAGCAGGTGAAGAAGGCCG TGGTGACGGT GCCGGCGTAC TTCAACGACT CGCAGCGCCA GGCAACGAAGGACGCCGGCA CGATTGCTGG CCTGGAGGTG CTGCGCATCA TCAACGAGCC GACGGCAGCGGCCATCGCGT ACGGTCTGGA CAAGGGCGAC GACGGCAAGG AGCGCAACGT GCTGATCTTCGACCTTGGCG GCGGCACGTT TGATGTGACG CTGCTGACGA TCGACGGCGG CATCTTCGAGGTGAAGGCGA CGAACGGCGA TACACACCTT GGCGGCGAGG ACTTCGACAA CCGCCTCGTCACGTTCTTCA CCGAGGAGTT CAAGCGCAAG AACAAGGGTA AGAACCTGGC GTCGAGCCACCGCGCGCTGC GCCGTCTGCG CACGGCGTGC GAGCGCGCGA AGCGCACGCT GTCGTCCGCGACGCAGGCGA CGATCGAGAT CGACGCGCTG TTCGAGAACA TTGACTTCCA GGCCACCATCACGCGCGCGC GCTTCGAGGA GCTGTGCGGC GACCTGTTCC GCAGCACGAT CCAGCCGGTGGAGCGCGTGC TGCAGGACGC GAAGATGGAC AAGCGCTCCG TGCACGACGT GGTGCTGGTGGGCGGGTCAA CGCGCATCCC GAAGGTGCAG TCCCTCGTGT CGGACTTCTT CGGCGGCAAGGAGCTGAACA AGAGCATCAA CCCCGACGAG GCTGTCGCGT ACGGCGCTGC GGTGCAGGCCTTCATCCTGA CGGGCGGCAA GAGCAAGCAG ACGGAGGGCC TGCTGCTGCT GGACGTGACGCCGCTGACGC TGGGCATCGA GACGGCCGGC GGCGTGATGA CGGCGCTGAT CAAGCGCAACACGACGATCC CGACCAAGAA GAGCCAGATC TTCTCGACGT ACGCGGACAA CCAGCCCGGCGTGCACATCC AGGTCTTCGA GGGCGAGCGC GCGATGACGA AGGACTGCCA CCTGCTGGGCACGTTCGACC TGTCCGGCAT CCCGCCGGCG CCGCGCGGCG TACCGCAGAT CGAGGTGACGTTCGACCTGG ACGCAAACGG CATCCTGAAC GTGTCCGCGG AGGAGAAGGG CACCGGCAAGCGCAACCAGA TCACCATCAC CAACGACAAG GGCCGGCTGA GCAAGGACGA GATCGAGCGCATGGTGAACG ACGCGATGAA GTACGAGGAG GACGACAAGG CACAGCGCGA CCGCGTGGAGGCAAAGAACG GCCTGGAGAA CTACGCGTAC TCGATGAAGA ACACGCTCAG CGACTCGAACGTGTCCGGCA AGCTGGACGA TAGCGACAAG GCCACGCTGA ACAAGGAGAT CGACGCGGCGCTGGAGTGGC TGAGCAGCAA CCAGGAGGCG ACGAAGGAGG AGTACGAGCA CAGGCAGAAGGAGCTGGAGA GCGTATGCAA CCCGATCATG ACCAAGATGT ACCAGAGCAT GGGCGGTGCTGCGGGCGGCA TGCCCGGCGG CATGCCCGGC GGTATGCCGG ACATGAGCGG CATGAGCGGTGGTGCAGGCC CGGCCGGCGG TGCGTCCTCT GGCCCCAAGG TCGAGGAGGT CGACTAA |
| Heat-shock protein hsp70, putative Q4Q7Y4] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; molecular function unknown |
| Biochemical Pathway | protein folding |
| Regulatory Pathway | |
| KEGG Pathways | K03283 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | heat shock 70kDa protein 1-like [Homo sapiens] | 71 | 0 | 862 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YJL034w nuclear fusion protein | Saccharomyces cerevisiae | 60% | 0 | 705 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 9-16; | PS00297 | |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 199-212; | PS00329 | |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 337-351; | PS01036 | |
| PDOC50099 | Sequence regions enriched in a particular amino acids | 8.634 | 618-651 | PS50315 |
| PDOC00015 | The rule PS00015 has been deleted from the PROSITE database and replaced by the following motif: PS50079 (Bipartite nuclear localization signal profile | 249-265; | PS00015 | |
| Acylation | N-myristoylation site | 8-13; 12-17; 19-24; 163-168; 185-190; 405-410; 410-415; 411-416; 618-623; 619-624; 622-627; 623-628; 626-631; 627-632; 637-642; 641-646; 646-651; | PS00008 | |
| Amidation | Amidation site | 74-77; 498-501; | PS00009 | |
| Glycosylation | N-glycosylation site | 35-38; 79-82; 152-155; 363-366; 420-423; 490-493; 560-563; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 418-421; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 45-48; 66-69; 96-99; 116-119; 224-227; 268-271; 333-336; 433-436; 492-495; 514-517; 555-558; 586-589; 591-594; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 47-49; 95-97; 154-156; 259-261; 343-345; 425-427; 498-500; 551-553; 562-564; 568-570; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 520-528; 542-550; | PS00007 | |
| Heat-shock protein hsp70, putative [Q4Q7Y4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1yuwA | |
| Percent Identity | 73% | |
| Target Region | 1-555 | |
| Template Region | 1-552 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 71 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/686532/Q4Q7Y4.pdb 2.0 555 = residues | | = | *| Ramachandran plot: 91.4% core 6.9% allow 1.2% gener 0.4% = disall | | = | +| All Ramachandrans: 16 labelled residues (out of 553) = | +| Chi1-chi2 plots: 2 labelled residues (out of 329) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 9 | *| Bond len/angle: 7.4 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.05 Covalent: -0.14 Overall: = -0.02 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 93.4% within limits 6.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |