| Heat shock protein 70, putative [Q4Q7Y0] | |
|---|---|
| Systematic Name | LmjF.28.2820 [Leishmania major] |
| Gene Name | LMJF_28_2820 |
| Molecular Weight | 72269 Da |
| Protein Sequence Size | 662 |
| Function | |
| Charge | -4.5 |
| Isoelectric Point | 6 pH |
| Description | Heat shock protein 70, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q7Y0|Q4Q7Y0_LEIMA Heat shock protein 70, putative - Leishmania major SFTEEFDGAIGIDLGTTYSCTAVFVRGQAEVIPNDMGNRTTPSCVAFYNDDVLVGDAAKT LLGRGVSGVVFDAKRMIGHHFSDKSIQEDRARWPFPISEGVKDSIQINVTHKGEELQLAP EQISAKVLTYLKECAERYLGKQVKKAVVTVPAYFNDAQRERTKAAATIAGLEVLRIINEP TAAALCYGLGIGSGTGQQQGEDQPRNVVVFDFGGGTFDVSVIVIDSGSFAVQATAGDTHL GGQDIDSNLLKYVLDDLQSRYNLRIAEQPRLLAKARTACERVKRVLSQSTAEELALDGVL PSGEEYTLSVSRAKLEELNASVFAQCMKVVQRALQDAAMKVEDVHEVVLVGGSSRIPKLN DMLRVFFNKARLCHSVHPDEAVAIGAAVQASILTNSLEQQSEKTANVVLMDVVPLSIGVE IDDGKFDVIVPRNTTIPYKVTKEYSTVEDYQHDVDVCVYEGERPLTKHNHKLGEFTLEGI TRAKKGKPTITVTFSIDANGLLTVTGTEELANKRHTLVVQNTDRLSEAQVKEMIDMAKKF AKSDAVDDAREAARRMVQGALEALFAAIAAMPRPPPSQLQKRLDAFTSHTRDWLERQLPS YSTVAEVEEKATKIAKLARKAMKKVEKKVRGGEPASKRHRDEGNGGNESSSDSDVENEAG K |
| DNA Sequence | >LmjF28.2820 |||heat shock protein 70, putative|Leishmania major|chr 28|||Manual ATGAGCTTCA CAGAGGAGTT TGATGGTGCC ATCGGCATCG ATCTCGGCAC GACGTACTCGTGCACCGCCG TCTTCGTGCG CGGGCAGGCG GAGGTGATCC CGAACGACAT GGGCAACCGCACCACACCAT CGTGCGTGGC CTTCTACAAC GATGACGTGC TCGTCGGCGA CGCTGCCAAGACGCTGCTCG GTCGCGGCGT CTCTGGAGTC GTGTTCGATG CGAAGCGCAT GATTGGCCACCACTTCAGCG ACAAGAGTAT TCAAGAGGAC CGCGCCCGCT GGCCGTTCCC CATCTCAGAGGGTGTAAAGG ACAGCATTCA GATCAACGTT ACGCACAAGG GCGAGGAGCT GCAGCTGGCACCGGAGCAGA TCTCTGCCAA GGTGCTAACC TACTTGAAGG AGTGTGCCGA GCGGTACCTGGGTAAGCAGG TGAAGAAGGC CGTGGTGACG GTGCCGGCGT ACTTCAACGA TGCACAGCGCGAGCGTACCA AGGCGGCGGC AACGATTGCT GGCCTGGAAG TGCTGCGCAT CATCAACGAGCCGACGGCGG CGGCGCTGTG CTACGGCCTC GGCATCGGCA GTGGCACAGG GCAACAGCAGGGCGAGGACC AGCCGCGCAA TGTCGTCGTC TTCGACTTCG GCGGCGGCAC GTTTGATGTGTCCGTCATCG TCATCGACAG CGGGAGCTTC GCGGTGCAGG CGACCGCCGG TGACACCCACCTGGGCGGGC AGGACATTGA CTCGAACCTT CTCAAGTATG TGCTGGACGA CTTGCAGTCGCGATACAACC TCCGCATCGC CGAGCAGCCG CGTCTGCTCG CGAAGGCCCG CACAGCGTGCGAACGGGTGA AGCGGGTTCT GTCGCAGTCA ACCGCCGAGG AACTGGCCCT GGATGGCGTGTTGCCGAGCG GCGAGGAGTA TACGCTATCT GTCTCCCGCG CAAAGCTGGA GGAGCTGAACGCGTCTGTGT TTGCGCAGTG CATGAAGGTG GTGCAGCGTG CCCTGCAGGA TGCAGCCATGAAGGTGGAAG ACGTTCATGA GGTCGTGCTC GTCGGCGGCA GCTCGCGCAT CCCGAAGCTGAACGACATGC TTCGCGTCTT TTTCAACAAA GCGAGACTGT GCCACTCGGT GCACCCGGACGAGGCGGTGG CCATCGGCGC CGCGGTGCAG GCCAGCATCC TCACCAACTC GCTTGAGCAACAGTCCGAGA AGACGGCCAA CGTCGTGCTC ATGGATGTGG TGCCGCTGAG CATCGGCGTAGAGATCGACG ATGGCAAGTT CGACGTCATC GTCCCCCGCA ATACGACCAT CCCGTACAAGGTGACGAAGG AGTACAGCAC AGTCGAAGAC TACCAGCACG ACGTTGACGT GTGCGTATACGAAGGAGAGC GGCCACTGAC AAAGCATAAC CACAAGCTGG GCGAGTTCAC ACTCGAGGGCATCACCCGTG CCAAGAAGGG CAAGCCCACC ATCACGGTGA CTTTCTCCAT CGACGCGAACGGCCTTCTCA CCGTCACCGG CACGGAGGAG TTGGCCAACA AGAGACACAC GCTCGTCGTGCAGAACACCG ACCGACTCTC CGAGGCGCAG GTGAAGGAGA TGATCGATAT GGCGAAGAAGTTCGCCAAGA GCGACGCTGT GGACGACGCC AGAGAAGCAG CGCGACGGAT GGTGCAGGGCGCACTCGAGG CTCTCTTCGC TGCCATCGCC GCGATGCCGC GGCCGCCGCC GTCACAGCTGCAGAAGCGAC TTGATGCCTT TACCTCGCAT ACGCGTGACT GGCTGGAGCG ACAGCTGCCCTCCTACTCGA CCGTCGCCGA GGTGGAAGAA AAGGCAACGA AGATCGCGAA ACTCGCCAGGAAAGCGATGA AGAAGGTGGA GAAGAAGGTG CGCGGCGGTG AGCCGGCCTC GAAGCGCCACCGCGACGAGG GAAACGGTGG CAACGAGTCC TCCAGCGACA GCGATGTGGA AAACGAGGCGGGCAAGTGA |
| Heat shock protein 70, putative Q4Q7Y0] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; molecular function unknown |
| Biochemical Pathway | protein folding |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | heat shock 70kDa protein 8 isoform 1 [Homo sapiens] | 48 | 1e-138 | 489 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YJL034w nuclear fusion protein | Saccharomyces cerevisiae | 42% | 1e-125 | 444 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 13-20; | PS00297 | |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 210-223; | PS00329 | |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 348-362; | PS01036 | |
| Acylation | N-myristoylation site | 12-17; 16-21; 101-106; 189-194; 191-196; 193-198; 197-202; 299-304; 480-485; 560-565; 632-637; 644-649; 646-651; 647-652; | PS00008 | |
| Glycosylation | N-glycosylation site | 39-42; 109-112; 320-323; 434-437; 648-651; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 514-517; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 2-5; 86-89; 235-238; 278-281; 290-293; 291-294; 303-306; 446-449; 447-450; 506-509; 604-607; 650-653; 652-655; 654-657; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 83-85; 111-113; 125-127; 354-356; 402-404; 523-525; 637-639; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 444-458; | PS00003 | |
| Heat shock protein 70, putative [Q4Q7Y0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1yuwA | |
| Percent Identity | 48% | |
| Target Region | 1-662 | |
| Template Region | 1-554 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 75 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
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| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/495232/Q4Q7Y0.pdb 2.0 662 = residues | | = | *| Ramachandran plot: 89.8% core 9.3% allow 0.5% gener 0.3% = disall | | = | +| All Ramachandrans: 16 labelled residues (out of 660) = | +| Chi1-chi2 plots: 5 labelled residues (out of 370) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 5.7 Bad contacts: = 10 | *| Bond len/angle: 6.7 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.06 Covalent: -0.14 Overall: = -0.02 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 94.1% within limits 5.9% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |