| Nuclear cap binding protein, putative [Q4Q7Q2] | |
|---|---|
| Systematic Name | LmjF.30.0540 [Leishmania major] |
| Gene Name | LMJF_30_0540 |
| Molecular Weight | 20775 Da |
| Protein Sequence Size | 188 |
| Function | |
| Charge | -5 |
| Isoelectric Point | 5.1 pH |
| Description | Nuclear cap binding protein, putative. |
| Subcellular Location | nucleus[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q7Q2|Q4Q7Q2_LEIMA Nuclear cap binding protein, putative - Leishmania major SSDLVDTVPRMEYVDRHELLRSLLTAEEFRERRQEQLNYSTTVYVGNLSFYTTEEQVCNH FSPCGHIRDIVMGLNEATRCPCGFCFVVFESQAAAVLAVHGLDGSLLDDRVVSVSWDVGC DGSRRWGRGAHGGQVVDGVRQNLDEGRGGLGALRRDALGVPASTAEDELVAYDWVEASPK RRGAHTK |
| DNA Sequence | >LmjF30.0540 |||nuclear cap binding protein, putative|Leishmania major|chr 30|||Manual ATGTCGAGTG ATTTGGTGGA CACGGTCCCC CGAATGGAGT ATGTGGATCG CCACGAGTTGCTCCGGTCTC TCTTGACGGC GGAGGAGTTC CGGGAGCGGC GGCAGGAGCA GCTCAACTACAGCACCACCG TTTACGTGGG CAACTTGTCC TTCTACACGA CGGAGGAGCA GGTGTGCAATCACTTCAGTC CTTGTGGACA CATCCGCGAT ATCGTGATGG GCCTCAACGA GGCGACACGCTGCCCATGCG GGTTTTGCTT TGTCGTGTTC GAGTCACAGG CGGCCGCGGT ACTGGCGGTGCACGGACTCG ACGGGTCACT GCTGGACGAC CGCGTCGTGT CCGTTAGCTG GGATGTGGGCTGCGACGGGA GTCGCCGCTG GGGCCGTGGC GCTCACGGCG GCCAAGTGGT AGACGGCGTTCGCCAAAACC TCGACGAGGG TCGCGGTGGC TTGGGCGCCC TGCGGCGCGA CGCGCTGGGCGTGCCTGCCT CGACCGCGGA GGACGAGCTG GTTGCCTACG ATTGGGTAGA AGCCTCACCGAAGCGCAGAG GTGCCCACAC AAAGTAG |
| Nuclear cap binding protein, putative Q4Q7Q2] | |
|---|---|
| Metabolite Information | |
| Molecular Function | RNA cap binding; nucleic acid binding |
| Biochemical Pathway | snRNA export from nucleus |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | nuclear cap binding protein subunit 2, 20kDa [Homo sapiens] | 48 | 2e-25 | 112 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER165w mRNA polyadenylate-binding protein | Saccharomyces cerevisiae | 24% | 0.00004 | 42 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00030 | Eukaryotic RNA recognition motif profile | 13.805 | 42-120 | PS50102 |
| Acylation | N-myristoylation site | 74-79; 102-107; 120-125; 130-135; 139-144; 149-154; 160-165; | PS00008 | |
| Glycosylation | N-glycosylation site | 39-42; 48-51; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 26-29; 53-56; 106-109; 164-167; 165-168; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 124-126; 179-181; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 33-40; | PS00007 | |
| Nuclear cap binding protein, putative [Q4Q7Q2] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1n54B | |
| Percent Identity | 48% | |
| Target Region | 1-122 | |
| Template Region | 6-115 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 8013-25-0 | GLYCEROL | 92.094 | C3 H8 O3 | OCC(O)CO | 1n54 |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/4098907/Q4Q7Q2.pdb 2.0 122 = residues | | = | *| Ramachandran plot: 88.2% core 8.2% allow 0.9% gener 2.7% = disall | | = | *| All Ramachandrans: 5 labelled residues (out of 120) = | +| Chi1-chi2 plots: 1 labelled residues (out of 68) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 4.0 Bad contacts: = 3 | +| Bond len/angle: 5.0 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: -0.04 Covalent: -0.17 Overall: = -0.09 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 92.8% within limits 7.2% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |