| Importin alpha, putative [Q4Q7J1] | |
|---|---|
| Systematic Name | LmjF.30.1120 [Leishmania major] |
| Gene Name | LMJF_30_1120 |
| Molecular Weight | 58150 Da |
| Protein Sequence Size | 539 |
| Function | |
| Charge | -16 |
| Isoelectric Point | 4.7 pH |
| Description | Importin alpha, putative. |
| Subcellular Location | importin alpha-subunit nuclear export complex[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q7J1|Q4Q7J1_LEIMA Importin alpha, putative - Leishmania major FNNQEKKGAKHAVSTKAGAERRQRQLMSVRHRVHGEVMKLLRAEGQDDFDMLGGNGSVAQ ASNPEDVWSYDARSTPASVPLQLLPTLVNMCMNGPTDREVFQGTLLIRKILSVEKDPPYD VVTSSGVVPHLVNLLQREDYPELQFESAWALTNIAAGTSENTMMLVACGAIPRFVALLGS PNADCRDQSAWAIGNLSGEGAACRDEALSHGAMVALLNVLSVKEQPIHVLRNATWAVSNL CRCKPLPPLERVAIALPTLVDLLNSSDDQLIVDAAWGISYISDGPAERVQSVLEAGAVPR IVQLLSVPSTNVKLPAIRIIGNIAAGTDEQTQVIINSGALPAMAELLRHPKRALRKETCW TISNIAAGQPYQIEALVNSNVCIPILECLSAPELDVRKEAVWTIANITFCGSVAQVKYLV NIGVIPPLCETLRTYDPKIVTVALEAVQCFLQVGEDEKTSGGTEENIVAKQVMDCGGVDS IEQLQTHADKNVYSIALQILETFFTTEDETGPMGDAMGADMVDFAQANPTAGSGQFNF |
| DNA Sequence | >LmjF30.1120 |||importin alpha, putative|Leishmania major|chr 30|||Manual ATGTTCAACA ACCAGGAGAA AAAGGGCGCC AAGCACGCCG TCAGCACCAA AGCTGGTGCTGAGCGTCGCC AGCGTCAGCT CATGTCAGTG CGTCACAGGG TTCACGGCGA AGTGATGAAGCTCCTGCGCG CCGAAGGTCA GGATGACTTT GATATGCTTG GTGGTAACGG CAGTGTGGCGCAGGCGTCCA ACCCAGAGGA TGTCTGGTCG TACGACGCCA GGTCGACACC CGCTTCGGTGCCCCTGCAGC TCCTCCCCAC CCTCGTGAAC ATGTGCATGA ATGGGCCTAC AGACCGTGAGGTGTTTCAGG GCACGCTGCT GATCCGCAAG ATCCTCTCCG TCGAGAAGGA CCCACCATACGATGTCGTGA CATCGAGCGG CGTTGTGCCG CACCTGGTGA ACTTGCTGCA GCGCGAGGACTACCCGGAGC TGCAGTTTGA GTCGGCCTGG GCCCTGACCA ACATCGCTGC AGGCACGTCGGAGAACACGA TGATGCTCGT CGCCTGTGGT GCGATTCCGC GCTTCGTTGC GCTGCTGGGTTCGCCGAACG CGGACTGCCG CGATCAGAGC GCATGGGCCA TCGGCAACCT TTCTGGTGAGGGCGCCGCCT GCCGTGACGA GGCGCTGAGC CACGGAGCCA TGGTCGCACT GCTGAACGTGCTGAGCGTGA AGGAACAGCC GATTCACGTT CTGCGCAACG CCACATGGGC CGTGTCGAACTTGTGCCGCT GCAAGCCGCT GCCGCCGCTG GAGCGGGTGG CGATCGCGCT GCCGACGCTGGTCGACCTCC TCAACAGCTC CGATGACCAG CTCATTGTGG ATGCTGCATG GGGTATTTCGTACATCAGCG ACGGACCGGC GGAGCGTGTG CAGTCGGTGC TCGAGGCCGG CGCTGTTCCGCGCATTGTGC AGCTCCTGTC CGTCCCCAGT ACGAACGTGA AGCTGCCGGC GATTCGCATCATTGGCAACA TCGCCGCCGG CACGGACGAG CAGACGCAGG TTATCATCAA CAGTGGTGCTCTGCCGGCCA TGGCTGAGCT GCTGCGCCAC CCGAAGCGTG CGCTGCGGAA GGAGACGTGCTGGACCATCT CCAACATTGC TGCCGGCCAG CCTTACCAGA TCGAGGCGCT CGTGAACTCGAATGTTTGCA TCCCCATCTT GGAGTGTCTT AGCGCGCCAG AGCTCGACGT GAGGAAGGAGGCGGTGTGGA CCATTGCGAA CATCACTTTC TGCGGCTCAG TGGCGCAGGT GAAGTACCTGGTCAACATTG GCGTCATCCC GCCACTGTGC GAGACGCTGC GCACGTACGA CCCGAAGATCGTGACGGTCG CGCTGGAGGC GGTGCAGTGC TTCCTGCAGG TCGGCGAGGA TGAGAAGACGTCGGGCGGCA CGGAGGAGAA CATTGTAGCG AAACAGGTGA TGGACTGCGG TGGCGTAGATTCCATCGAGC AGCTGCAGAC GCACGCCGAC AAGAACGTGT ACAGCATCGC GCTTCAGATCCTGGAGACCT TCTTCACGAC GGAGGACGAG ACGGGCCCAA TGGGCGATGC TATGGGTGCTGACATGGTGG ACTTTGCGCA GGCCAACCCC ACCGCCGGCA GCGGTCAGTT CAACTTCTAA |
| Importin alpha, putative Q4Q7J1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | nuclear localization sequence binding |
| Biochemical Pathway | protein import into nucleus |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | PREDICTED: similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) isoform 4 [Homo sapiens] | 43 | 5e-97 | 352 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YNL189w karyopherin-alpha or importin | Saccharomyces cerevisiae | 40% | 2e-91 | 330 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC50176 | Armadillo/plakoglobin ARM repeat profile | 12.337; 9.222; 10.832 | 127-170; 212-241; 297-339 | PS50176 |
| PDOC00029 | Leucine zipper pattern | 250-271; | PS00029 | |
| Acylation | N-myristoylation site | 9-14; 54-59; 158-163; 180-185; 195-200; 212-217; 322-327; 339-344; 463-468; 477-482; | PS00008 | |
| Glycosylation | N-glycosylation site | 56-59; 196-199; 233-236; 265-268; 407-410; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 356-359; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 63-66; 97-100; 222-225; 259-262; 266-269; 292-295; 391-394; 487-490; 506-509; 507-510; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 15-17; 29-31; 97-99; 222-224; 432-434; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 64-78; 113-127; 134-148; | PS00003 | |
| Importin alpha, putative [Q4Q7J1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1q1tC | |
| Percent Identity | 44% | |
| Target Region | 79-503 | |
| Template Region | 72-422 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/5085018/Q4Q7J1.pdb 2.0 423 = residues | | = | *| Ramachandran plot: 94.6% core 5.1% allow 0.0% gener 0.3% = disall | | = | +| All Ramachandrans: 6 labelled residues (out of 421) = | +| Chi1-chi2 plots: 4 labelled residues (out of 227) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 6.6 Bad contacts: = 1 | *| Bond len/angle: 6.4 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.29 Covalent: -0.05 Overall: = 0.15 | | = | | M/c bond lengths: 99.0% within limits 1.0% highlighted = | *| M/c bond angles: 95.6% within limits 4.4% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |