LeishBase: Leishmania Structural Database

LeishBase: Leishmania Structural Database


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Succinyl-coa:3-ketoacid-coenzyme a transferase-like protein [Q4Q7A3]
Systematic Name	LmjF.30.1930 [Leishmania major]
Gene Name	LMJF_30_1930
Molecular Weight	53784 Da
Protein Sequence Size	498
Function
Charge	6
Isoelectric Point	7.9 pH
Description	Succinyl-coa:3-ketoacid-coenzyme a transferase-like protein.
Subcellular Location	N.A.[Predict]
E. C. Number	N.A.
Sequence	>tr\|Q4Q7A3\|Q4Q7A3_LEIMA Succinyl-coa:3-ketoacid-coenzyme a transferase-like protein - Leishmania major LRRTLLRFKPTILTAAEALQDVKDGATIALGGFGLCGFPFELLEALNQKGTKQLTLIAGT TSGPENGTGPLARDRQLKKIITSYVGENSVLSDRLMNGEFAIEFCPMGTLVDRLRAAGAG LPAFYTPTGYGTAVAEGRLPVRFAPGKPVRVAEYSQPRETRQFNGRWCTLEMALPADFAL VRAWKADRRGNLVFRGTTQNFNLASAKAAKVCIAEVEEIVECGELDPKTVHLPGVYVHRL VCPPNIRRAAEFVVERKPGFSTGTGKNAHASRNLIARRAALEIKDGMTLNLGIGIPNMVA SYIPPEMDVVLQGENGLLGIGPYPLPEEVDPDITNAGKQTVTMSKSGASLFDSAESFSMI RGGHLDLTMLGALEVSGTGDIASWWIPGKLLKGMGGAMDLVMSGCRTVVLMEHTDREGKP RVVESCRVPLTGTGVVDLLITELCTFRFVKQKGGINEMWLSELSEGVTLEEVRAKTSAAF KVDPHLKMMPRADPLPT
DNA Sequence	>LmjF30.1930 \|\|\|succinyl-coa:3-ketoacid-coenzyme a transferase-like protein\|Leishmania major\|chr 30\|\|\|Manual ATGCTCCGTC GAACGCTGCT TCGCTTCAAG CCGACCATCC TGACGGCAGC CGAGGCGCTCCAGGATGTGA AGGATGGCGC GACCATCGCG CTCGGCGGCT TCGGCCTTTG CGGCTTCCCGTTCGAGCTAC TCGAAGCGCT TAACCAGAAG GGCACAAAAC AGCTTACCCT CATCGCTGGTACGACATCGG GGCCTGAGAA CGGGACTGGG CCCCTCGCGC GCGATAGGCA GCTAAAGAAGATCATCACGA GCTACGTTGG CGAGAACAGC GTTCTCTCGG ATCGACTCAT GAATGGCGAGTTTGCAATCG AGTTTTGCCC CATGGGCACG TTGGTGGACC GGCTGCGCGC TGCGGGTGCCGGGCTGCCCG CCTTCTACAC CCCCACCGGC TACGGCACAG CGGTAGCCGA GGGCCGCCTCCCTGTGCGCT TTGCGCCGGG CAAGCCCGTG AGGGTGGCCG AGTACAGCCA GCCACGCGAGACGCGGCAGT TCAACGGGCG GTGGTGCACG CTGGAGATGG CGCTGCCAGC GGACTTTGCGCTTGTGCGCG CGTGGAAGGC GGACAGGCGC GGCAACCTCG TGTTCCGCGG GACAACGCAGAACTTTAACC TTGCGTCCGC GAAGGCTGCG AAGGTGTGCA TCGCGGAGGT GGAGGAGATTGTGGAGTGCG GGGAGCTAGA CCCGAAGACG GTGCACCTGC CCGGCGTGTA TGTGCACCGCCTGGTGTGCC CACCGAACAT CAGGAGAGCC GCCGAGTTCG TGGTGGAGCG CAAGCCCGGGTTCTCGACGG GGACGGGGAA GAACGCGCAT GCAAGCCGCA ATCTCATAGC TCGCCGCGCAGCCCTTGAGA TCAAGGATGG CATGACTCTG AACCTTGGCA TTGGCATCCC CAACATGGTGGCGAGCTACA TTCCGCCGGA GATGGACGTG GTGCTGCAGG GAGAAAACGG CTTACTCGGCATTGGCCCCT ACCCGCTGCC GGAGGAGGTG GACCCCGACA TCACTAACGC CGGCAAGCAGACTGTCACCA TGAGCAAGTC AGGCGCTTCG CTGTTCGACA GCGCCGAGTC CTTCAGCATGATTCGCGGTG GCCATTTGGA CTTGACGATG CTTGGCGCGC TGGAGGTCTC TGGCACCGGCGACATTGCCA GCTGGTGGAT ACCTGGCAAG CTGCTGAAGG GCATGGGTGG CGCCATGGACCTTGTCATGT CGGGCTGCCG TACTGTCGTG CTGATGGAGC ACACGGACAG GGAGGGTAAGCCCCGCGTGG TGGAATCGTG CAGGGTGCCG CTCACCGGCA CCGGCGTGGT TGACCTGCTCATCACGGAGC TTTGCACGTT CCGCTTTGTA AAGCAGAAGG GCGGCATCAA CGAAATGTGGCTGTCGGAGC TCTCCGAGGG CGTCACGCTG GAGGAGGTGC GCGCAAAGAC AAGTGCTGCGTTCAAGGTTG ACCCACATCT CAAAATGATG CCGCGAGCGG ATCCTCTACC AACTTGA

Succinyl-coa:3-ketoacid-coenzyme a transferase-like protein Q4Q7A3]
Metabolite Information
Molecular Function	CoA-transferase activity
Biochemical Pathway	metabolism
Regulatory Pathway
KEGG Pathways	K01029

Orthologs
Homologs	GI	Percent Identity	Evalue	Score
Homo sapiens	3-oxoacid CoA transferase 1 precursor [Homo sapiens]	47	1e-118	424

DEG Information
DEG Protein	DEG Organism	Percent Identity	Evalue	Bit Score
atoA acetate CoA-transferase beta subunit	Haemophilus influenzae	42%	6e-46	179

Post Translational Modification
PTM Type	PTM Sub Type	Score	Modification Site	Prosite ID
PDOC00980	Coenzyme A transferases signatures		25-40;	PS01273
Acylation	N-myristoylation site		26-31; 132-137; 197-202; 264-269; 287-292; 394-399;	PS00008
Glycosylation	N-glycosylation site		67-70;	PS00001
Phosphorylation	Casein kinase II phosphorylation site		15-18; 63-66; 110-113; 350-353; 415-418; 469-472;	PS00006
Phosphorylation	Protein kinase C phosphorylation site		93-95; 206-208; 265-267; 415-417; 426-428; 446-448;	PS00005

Succinyl-coa:3-ketoacid-coenzyme a transferase-like protein [Q4Q7A3]
Model Information
Template PDB ID	1ooyB
Percent Identity	46%
Target Region	1-499
Template Region	1-468

Domain Information
Domains	Start	End

Active Site Information
Residue	Active Site Number	Functional Part

Co-Factor
Metal	Description

Ligands
CAS number	Name	Mol. Weight	Mol. Formula	Smile Notation	PDB Reference
24203-36-9	POTASSIUM ION	39.098	K	[K+]	1ooy
14265-44-2	PHOSPHATE ION	94.971	O4 P	[O-]P([O-])([O-])=O	1ooy

Mutational Information
Residue	Feature	Description


Modeled Protein	Template Structure
	+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ \| = \| \| /var/www/html/Services/SAVES_3/jobs/1738944/Q4Q7A3.pdb 2.0 498 = residues \| \| = \| \| Ramachandran plot: 92.0% core 6.3% allow 1.5% gener 0.2% = disall \| \| = \| +\| All Ramachandrans: 8 labelled residues (out of 496) = \| +\| Chi1-chi2 plots: 3 labelled residues (out of 266) = \| \| = \| \| Main-chain params: 6 better 0 inside 0 worse = \| \| Side-chain params: 5 better 0 inside 0 worse = \| \| = \| \| Residue properties: Max.deviation: 4.0 Bad contacts: = 7 \| \| Bond len/angle: 13.6 Morris et al class: 1 = 1 2 \| \| = \| \| G-factors Dihedrals: -0.06 Covalent: -0.34 Overall: = -0.17 \| \| = \| \| M/c bond lengths: 98.0% within limits 2.0% highlighted 2 off = graph \| \| M/c bond angles: 91.9% within limits 8.1% highlighted 3 off = graph \| \| Planar groups: 100.0% within limits 0.0% highlighted = \| \| = \| = +------------------------------------------------------------------------= ----+ + May be worth investigating further. Worth investigating further.
Overlapped Structure	Procheck Summary

LeishBase: Leishmania Structural Database