| Heat shock 70-related protein 1, mitochondrial, putative [Q4Q744] | |
|---|---|
| Systematic Name | LmjF.30.2490 [Leishmania major] |
| Gene Name | LMJF_30_2490 |
| Molecular Weight | 71621 Da |
| Protein Sequence Size | 660 |
| Function | |
| Charge | -5 |
| Isoelectric Point | 5.7 pH |
| Description | Heat shock 70-related protein 1, mitochondrial, putative. |
| Subcellular Location | Mitochondrion[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q744|Q4Q744_LEIMA Heat shock 70-related protein 1, mitochondrial, putative - Leishmania major FARRVCGSAAASAACLARHESQKVQGDVIGVDLGTTYSCVATMDGDKARVLENSEGFRTT PSVVAFKGSEKLVGLAAKRQAITNPQSTFYAVKRLIGRRFEDEHIQKDIKNVPYKIVRAG NGDAWVQDGNGKQYSPSQIGAFVLEKMKETAENFLGHKVSNAVVTCPAYFNDAQRQATKD AGTIAGLNVIRVVNEPTAAALAYGMDKTKDSLIAVYDLGGGTFDISVLEIAGGVFEVKAT NGDTHLGGEDFDLALSDYILEEFRKTSGIDLSKERMALQRVREAAEKAKCELSSAMETEV NLPFITANADGAQHIQMHISRSKFEGITQRLIERSIAPCKQCMKDAGVELKEINDVVLVG GMTRMPKVVEEVKKFFQKDPFRGVNPDEAVALGAATLGGVLRGDVKGLVLLDVTPLSLGI ETLGGVFTRMIPKNTTIPTKKSQTFSTAADNQTQVGIKVFQGEREMAADNQMMGQFDLVG IPPAPRGVPQVEVTFDIDANGICHVTAKDKATGKTQNITITANGGLSKEQIEQMIRDSEQ HAEADRVKRELVEVRNNAETQLTTAERQLGEWKYVSDAEKENVKTLVAELRKAMENPNVA KDDLAAATDKLQKAVMECGRTEYQQAAAANSGSTSNSGEQQQQQSQGEQQQQQNSEEKK |
| DNA Sequence | >LmjF30.2490 |||heat shock 70-related protein 1, mitochondrial precursor, putative|Leishmania major|chr 30|||Manual ATGTTTGCTC GTCGTGTGTG CGGAAGCGCT GCGGCGTCGG CTGCGTGCCT GGCGCGCCACGAGTCGCAGA AGGTGCAGGG CGACGTGATT GGCGTGGACC TGGGCACGAC GTACAGCTGCGTGGCGACGA TGGACGGCGA CAAGGCGCGC GTGCTGGAGA ACTCGGAGGG CTTCCGGACGACGCCGTCTG TTGTGGCGTT CAAGGGCAGC GAGAAGCTTG TGGGGCTTGC GGCGAAGCGGCAGGCGATCA CGAACCCGCA GTCGACGTTC TATGCTGTGA AGCGGCTGAT CGGGCGCCGGTTCGAGGACG AGCACATCCA GAAGGACATC AAGAACGTGC CGTACAAGAT CGTGCGCGCGGGGAACGGTG ACGCGTGGGT GCAGGACGGG AACGGGAAGC AGTACTCGCC GTCGCAGATCGGCGCGTTCG TGCTGGAGAA GATGAAGGAG ACGGCGGAGA ACTTCCTGGG GCACAAGGTGAGCAACGCCG TCGTGACGTG CCCGGCGTAC TTCAACGACG CGCAGCGCCA GGCGACGAAGGACGCGGGGA CGATCGCGGG CCTGAACGTG ATCCGCGTGG TGAACGAGCC GACTGCTGCGGCGCTTGCGT ACGGCATGGA CAAGACGAAG GACAGCCTGA TCGCGGTGTA CGACCTCGGTGGCGGCACGT TCGATATCTC CGTGCTGGAG ATCGCTGGCG GCGTGTTCGA GGTGAAGGCGACGAACGGCG ACACGCACCT TGGCGGCGAG GACTTTGACC TGGCGCTGTC GGACTACATCCTGGAGGAGT TCCGCAAGAC GAGCGGGATC GACCTGAGCA AGGAGCGGAT GGCGCTGCAGCGCGTGCGCG AGGCCGCGGA GAAGGCGAAG TGCGAGCTGT CGTCTGCGAT GGAGACGGAGGTGAACCTGC CGTTCATCAC TGCGAACGCC GACGGCGCGC AGCACATCCA GATGCACATCAGCCGTAGCA AGTTCGAGGG CATCACGCAG CGGCTGATCG AGCGGTCGAT TGCGCCGTGCAAGCAGTGCA TGAAGGACGC TGGTGTGGAG CTGAAGGAGA TCAACGACGT TGTGCTTGTTGGCGGCATGA CGCGCATGCC GAAGGTGGTG GAGGAGGTGA AGAAGTTCTT CCAGAAGGACCCGTTCCGCG GCGTGAACCC CGACGAGGCT GTGGCGCTTG GTGCCGCGAC GCTGGGCGGCGTGCTGCGCG GCGACGTGAA GGGGCTTGTG CTGCTGGACG TGACGCCTCT GTCGCTGGGCATTGAGACGC TCGGCGGCGT GTTCACGCGC ATGATCCCGA AGAACACGAC GATCCCGACGAAGAAGAGCC AGACGTTCTC GACTGCGGCG GACAACCAGA CGCAGGTGGG GATCAAGGTGTTCCAGGGCG AGCGCGAGAT GGCCGCGGAC AACCAGATGA TGGGTCAGTT CGACTTGGTGGGCATCCCGC CCGCGCCGCG TGGGGTGCCG CAGGTCGAGG TGACGTTCGA CATCGACGCGAACGGCATCT GCCACGTGAC GGCGAAGGAC AAGGCGACGG GCAAGACGCA GAACATCACGATCACGGCGA ACGGCGGGCT GTCGAAGGAG CAGATCGAGC AGATGATCCG CGACTCGGAGCAGCACGCGG AGGCCGACCG CGTGAAGCGC GAGCTTGTGG AGGTGCGCAA CAACGCGGAGACGCAGCTGA CAACGGCGGA GAGGCAGCTC GGCGAGTGGA AGTACGTGAG CGATGCGGAGAAGGAGAACG TGAAGACGCT GGTGGCGGAG CTGCGCAAGG CGATGGAGAA CCCGAACGTGGCGAAGGATG ACCTTGCGGC TGCGACGGAC AAGCTGCAGA AGGCTGTGAT GGAGTGCGGCCGCACAGAGT ACCAGCAGGC TGCCGCGGCC AACTCCGGCA GCACCAGCAA CTCCGGTGAGCAGCAGCAGC AGCAGAGCCA AGGTGAGCAG CAGCAGCAGC AGAACAGCGA GGAGAAAAAGTAG |
| Heat shock 70-related protein 1, mitochondrial, putative Q4Q744] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; molecular function unknown |
| Biochemical Pathway | pathogenesis; protein folding |
| Regulatory Pathway | |
| KEGG Pathways | K04043 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | heat shock 70kDa protein 9B precursor [Homo sapiens] | 62 | 0 | 721 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YJR045c mitochondrial heat shock protein 70-related protein | Saccharomyces cerevisiae | 58% | 0 | 674 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 403-405; | PS00016 | |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 32-39; | PS00297 | |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 216-229; | PS00329 | |
| PDOC00269 | Heat shock hsp70 proteins family signatures | 357-371; | PS01036 | |
| PDOC00013 | Prokaryotic membrane lipoprotein lipid attachment site profile | 6-16; | PS51257 | |
| PDOC50099 | Sequence regions enriched in a particular amino acids | 9.652 | 641-654; | PS50322 |
| Acylation | N-myristoylation site | 8-13; 31-36; 35-40; 121-126; 183-188; 205-210; 269-274; 400-405; 425-430; 633-638; | PS00008 | |
| Amidation | Amidation site | 97-100; | PS00009 | |
| Glycosylation | N-glycosylation site | 435-438; 452-455; 518-521; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 265-268; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 227-230; 241-244; 268-271; 295-298; 323-326; 448-451; 507-510; 564-567; 577-580; 646-649; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 22-24; 70-72; 329-331; 440-442; 507-509; 513-515; 609-611; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 568-575; | PS00007 | |
| Heat shock 70-related protein 1, mitochondrial, putative [Q4Q744] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1yuwA | |
| Percent Identity | 48% | |
| Target Region | 25-581 | |
| Template Region | 2-554 | |
| Domain Information | ||
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| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 70 | Sidechain |
| Co-Factor | |
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| Metal | Description |
| Ligands | |||||
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| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
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| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1367454/Q4Q744.pdb 2.0 547 = residues | | = | *| Ramachandran plot: 91.8% core 6.7% allow 0.6% gener 0.8% = disall | | = | +| All Ramachandrans: 14 labelled residues (out of 545) = | +| Chi1-chi2 plots: 2 labelled residues (out of 309) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 3 | *| Bond len/angle: 7.2 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.08 Covalent: -0.14 Overall: = 0.00 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | *| M/c bond angles: 95.1% within limits 4.9% highlighted 1 off = graph | +| Planar groups: 99.5% within limits 0.5% highlighted 1 off = graph | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |