| Casein kinase 1 isoform 2, putative [Q4Q6U1] | |
|---|---|
| Systematic Name | LmjF.30.3470 [Leishmania major] |
| Gene Name | LMJF_30_3470 |
| Molecular Weight | 42313 Da |
| Protein Sequence Size | 376 |
| Function | |
| Charge | 1.5 |
| Isoelectric Point | 6.6 pH |
| Description | Casein kinase 1 isoform 2, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q6U1|Q4Q6U1_LEIMA Casein kinase 1 isoform 2, putative - Leishmania major GTRSKRAQDVLIGGRFRIQERLGGGAFGEVFRGVELNSGHPVAMKMELTKDGYRSHLNLE NRIYKKLNECPVTVGIPKSYYCDRVGDYTVMVMDLLGPCLDDLFEVCHHKFSFKTVCMIG IQVIQRLQYIHSVGFLHRDIKPENFVMGVGTNSHIVYVIDVGLSKAWHDSTGKHILYAEG KSLTGTARYVSINTHRGIQQSRRDDLESVSYLLAYFARGHLPWQGLKSPKKDARFERIRD VKTATSPAELCKGYPHQFADYVEYTRSLGFEAEPDYSYCVGLFSSAMADMGEQYDYCYQW IDRSEAEVKSELDALGSTHSLRTSGAQTSVAVGGSDLMASSVFMGDSAVNEMSKSLLNTN FMEENQDYYGLNDYI |
| DNA Sequence | >LmjF30.3470 |||casein kinase 1 isoform 2, putative|Leishmania major|chr 30|||Manual ATGGGCACAA GGAGCAAACG TGCCCAGGAT GTGCTGATCG GCGGCCGCTT CCGCATTCAGGAGCGCTTGG GCGGTGGCGC CTTTGGTGAG GTGTTCAGAG GTGTCGAGTT GAACAGCGGCCACCCTGTTG CCATGAAGAT GGAGCTGACG AAGGATGGCT ATCGTTCGCA CCTCAACCTGGAGAACCGAA TCTACAAAAA GCTCAACGAG TGTCCGGTGA CTGTCGGCAT CCCAAAGTCCTACTACTGCG ATCGCGTGGG CGATTACACT GTCATGGTAA TGGACCTTCT CGGCCCGTGCCTGGATGATC TCTTTGAAGT GTGCCACCAC AAGTTTAGCT TTAAGACGGT CTGCATGATCGGCATCCAGG TCATTCAGCG GCTTCAGTAT ATCCACAGCG TTGGCTTCCT GCATCGCGACATCAAGCCAG AGAACTTCGT CATGGGCGTC GGCACCAACT CTCACATCGT GTACGTGATCGACGTGGGTC TCTCCAAGGC GTGGCACGAC TCTACGGGGA AGCATATTCT GTACGCGGAGGGCAAGTCGT TGACTGGCAC AGCACGCTAC GTTAGTATCA ACACACACCG GGGCATTCAACAGTCTCGGC GCGATGACCT CGAATCCGTC TCCTACCTGC TTGCCTACTT CGCGCGTGGCCACCTACCCT GGCAGGGGCT CAAATCACCA AAGAAGGATG CACGCTTTGA GCGCATTCGCGACGTTAAGA CCGCCACGTC GCCGGCGGAG CTGTGCAAGG GCTATCCCCA CCAGTTCGCCGATTACGTCG AGTATACGCG CTCCCTCGGC TTCGAGGCAG AGCCAGACTA CAGCTACTGTGTGGGGCTGT TTTCTTCGGC GATGGCGGAC ATGGGGGAGC AGTACGACTA CTGCTACCAGTGGATCGACC GAAGCGAGGC CGAGGTCAAG TCCGAGCTCG ACGCGCTCGG GTCCACTCATAGCCTGCGCA CCTCTGGGGC GCAGACAAGT GTTGCTGTCG GAGGCTCCGA CCTCATGGCCTCCTCCGTCT TTATGGGAGA CAGCGCGGTG AACGAGATGA GCAAATCCCT TTTGAATACTAACTTTATGG AGGAGAACCA AGACTACTAC GGCCTTAACG ATTACATCTG A |
| Casein kinase 1 isoform 2, putative Q4Q6U1] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity |
| Biochemical Pathway | protein amino acid phosphorylation |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | casein kinase 1, delta isoform 2 [Homo sapiens] | 49 | 1e-81 | 300 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YPL204w casein kinase I, serthrtyr protein kinase | Saccharomyces cerevisiae | 46% | 5e-78 | 285 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00394 | Heme peroxidase signatures and profiles | 312-322; | PS00435 | |
| PDOC00100 | Protein kinases signatures and profile | 23-46; | PS00107 | |
| PDOC00100 | Protein kinases signatures and profile | 136-148; | PS00108 | |
| PDOC00100 | Protein kinases signatures and profile | 23.863 | 17-376 | PS50011 |
| Acylation | N-myristoylation site | 25-30; 34-39; 76-81; 149-154; 163-168; 198-203; 282-287; 317-322; 326-331; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 202-205; 247-250; 305-308; 311-314; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 5-7; 113-115; 172-174; 187-189; 195-197; 202-204; 229-231; 321-323; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 204-212; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 270-284; 288-302; 362-376; | PS00003 | |
| Casein kinase 1 isoform 2, putative [Q4Q6U1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1ckjB | |
| Percent Identity | 49% | |
| Target Region | 9-298 | |
| Template Region | 1-286 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 132 | Sidechain |
| LYS | 134 | Sidechain |
| ASN | 137 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14311-52-5 | TUNGSTATE(VI)ION | 247.838 | O4 W | [O-][W]([O-])(=O)=O | 1ckj |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/780274/Q4Q6U1.pdb 2.0 289 = residues | | = | +| Ramachandran plot: 93.2% core 6.0% allow 0.8% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 287) = | +| Chi1-chi2 plots: 3 labelled residues (out of 177) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.4 Bad contacts: = 4 | *| Bond len/angle: 5.4 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.14 Covalent: -0.10 Overall: = 0.05 | | = | | M/c bond lengths: 99.7% within limits 0.3% highlighted = | | M/c bond angles: 94.7% within limits 5.3% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |