| O-sialoglycoprotein endopeptidase, putative [Q4Q6Q4] | |
|---|---|
| Systematic Name | LmjF.31.0100 [Leishmania major] |
| Gene Name | LMJF_31_0100 |
| Molecular Weight | 39871 Da |
| Protein Sequence Size | 364 |
| Function | |
| Charge | 6 |
| Isoelectric Point | 7.6 pH |
| Description | O-sialoglycoprotein endopeptidase, putative (Metallo-peptidase, clan mk, family m67) (EC 3.4.24.57). |
| Subcellular Location | integral to membrane[Predict] |
| E. C. Number | 3.4.24.57 |
| Sequence | >tr|Q4Q6Q4|Q4Q6Q4_LEIMA O-sialoglycoprotein endopeptidase, putative (Metallo-peptidase, clan mk, family m67) (EC 3.4.24.57) - Leishmania major. KRTLSLGIEGSANKIGVGVVDQSGTVLSNVRETYITPPGSGFLPRETAIHHSQHVLQVVQ RAMHDAAVTPADIDIISYTKGPGMGGPLSVGCTVAKTLSLLWGKPLVGVNHCVGHIEMGR VVTKSENPVVLYVSGGNTQVIAYADHRYRIFGETIDIAVGNCLDRVARLLNISNDPAPGY NIEQKAKKGKCYIRLPYTVKGMDMSFTGILSYIEQLVHHPQFSDSDVREMSKKRHKAAPS LTSMPVPPGETLNTDDICFSLQETIFAMLVEVTERAMSQIKTSDVLIVGGVGCNRRLQEM MQLMAAERGGRCFGMDQRYCIDNGCMIAYAGLLQYLSGSFTTMAEATVTQRFRTDEVYVT WRD |
| DNA Sequence | >LmjF31.0100 |||O-sialoglycoprotein endopeptidase, putative|Leishmania major|chr 31|||Manual ATGAAGCGCA CACTGTCCCT CGGGATCGAG GGAAGCGCCA ATAAGATCGG TGTGGGGGTGGTGGACCAGA GCGGTACGGT GCTCTCTAAC GTGCGCGAAA CCTACATCAC CCCACCTGGGTCCGGGTTCC TGCCGCGCGA GACGGCCATC CACCACTCCC AGCACGTGCT GCAGGTCGTACAGCGCGCCA TGCACGATGC CGCGGTGACG CCGGCCGACA TCGACATCAT CTCGTACACCAAGGGCCCTG GCATGGGCGG GCCGCTCTCT GTCGGCTGCA CCGTGGCCAA AACACTGTCCCTCCTGTGGG GGAAGCCGCT GGTGGGCGTC AACCACTGCG TCGGGCACAT TGAGATGGGCCGCGTCGTCA CGAAGAGCGA GAACCCCGTG GTGCTGTACG TCAGCGGGGG CAACACGCAAGTCATCGCCT ACGCTGATCA CCGCTACCGC ATTTTCGGTG AGACGATCGA CATTGCCGTGGGCAACTGCC TGGACCGTGT TGCCCGCCTC CTCAACATCT CAAACGACCC GGCACCGGGCTACAACATTG AACAGAAGGC CAAGAAGGGC AAGTGCTACA TCCGCTTGCC CTACACGGTGAAGGGAATGG ACATGTCGTT CACCGGCATC CTCTCCTACA TCGAACAGCT TGTGCACCACCCTCAATTCT CTGACTCGGA TGTTCGCGAG ATGTCCAAAA AGCGGCACAA GGCGGCACCGTCGCTGACCA GCATGCCGGT GCCGCCCGGC GAGACCCTCA ACACAGACGA CATCTGCTTCTCCTTGCAGG AGACGATCTT CGCCATGCTA GTCGAAGTGA CGGAGCGCGC CATGTCGCAAATCAAAACAT CTGACGTGCT CATTGTTGGG GGGGTGGGCT GCAACAGGCG CCTGCAGGAGATGATGCAGC TGATGGCGGC AGAGCGTGGG GGTCGCTGCT TCGGCATGGA TCAGCGATACTGCATCGACA ATGGCTGCAT GATTGCGTAT GCCGGGCTGC TCCAGTACCT CAGTGGGTCCTTCACGACCA TGGCGGAGGC GACTGTCACG CAGCGCTTTC GCACCGATGA AGTTTACGTGACGTGGCGCG ATTGA |
| O-sialoglycoprotein endopeptidase, putative Q4Q6Q4] | |
|---|---|
| Metabolite Information | |
| Molecular Function | O-sialoglycoprotein endopeptidase activity |
| Biochemical Pathway | proteolysis |
| Regulatory Pathway | |
| KEGG Pathways | K01409 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | O-sialoglycoprotein endopeptidase [Homo sapiens] | 60 | 1e-120 | 427 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| glycoprotease family protein | Streptococcus pneumoniae | 29% | 3e-34 | 139 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00081 | Cytochrome P450 cysteine heme-iron ligand signature | 314-323; | PS00086 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 172-175; | PS00722 | |
| PDOC00779 | Glycoprotease family signature | 97-117; | PS01016 | |
| Acylation | N-myristoylation site | 8-13; 25-30; 86-91; 92-97; 109-114; 202-207; 290-295; 291-296; 325-330; 339-344; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 70-73; 124-127; 212-215; 224-227; 261-264; 343-346; 361-364; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 199-201; 232-234; 274-276; 350-352; 361-363; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 352-359; | PS00007 | |
| O-sialoglycoprotein endopeptidase, putative [Q4Q6Q4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2ivpA | |
| Percent Identity | 41% | |
| Target Region | 4-363 | |
| Template Region | 1-325 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Zn | |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 84412-18-0 | ADENOSINE-5'-TRIPHOSPHATE | 507.181 | C10 H16 N5 O13 P3 | O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 2ivp |
| FE (II) ION | 55.845 | Fe | [Fe+2] | 2ivp | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/413540/Q4Q6Q4.pdb 2.0 360 = residues | | = | +| Ramachandran plot: 92.9% core 6.5% allow 0.6% gener 0.0% = disall | | = | +| All Ramachandrans: 10 labelled residues (out of 358) = | +| Chi1-chi2 plots: 3 labelled residues (out of 194) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.3 Bad contacts: = 2 | *| Bond len/angle: 7.2 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.05 Covalent: -0.16 Overall: = -0.03 | | = | | M/c bond lengths: 98.7% within limits 1.3% highlighted = | | M/c bond angles: 93.0% within limits 7.0% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |