| Mevalonate kinase, putative [Q4Q6K7] | |
|---|---|
| Systematic Name | LmjF.31.0560 [Leishmania major] |
| Gene Name | LMJF_31_0560 |
| Molecular Weight | 35485 Da |
| Protein Sequence Size | 329 |
| Function | |
| Charge | 11 |
| Isoelectric Point | 9.2307 pH |
| Description | Mevalonate kinase, putative (EC 2.7.1.36). |
| Subcellular Location | cytoplasm[Predict] |
| E. C. Number | 2.7.1.36 |
| Sequence | >tr|Q4Q6K7|Q4Q6K7_LEIMA Mevalonate kinase, putative (EC 2.7.1.36) - Leishmania major SKPVKSKTTGKNIGYGKVILFGEHFVVHGAEAIVAGISEYTECRLEINPGVPGLQVDDQR PAIPGYIAQKRDEQIKAHQLVLDHLKVDLSGDGLKMFIGGPLVPSSGIGASASDVVAFSR ALSELYQLNLTDEEVNLSAFVGEGGYHGTPSGADNTAATYGGLILYRRQNGKSVFKPIAF QQRLYLVVVGTGINASTAKVVNDVHKMKQQQPVQFKRLYDNYTHIVSQAREALQKGDLQR LGQLMNANHDLCRQIDVSCRELESIVQTCRTYGALGAKLSGTGRGGIAVALAASSDQRDA IVKGLKAKCPEAKFIWRYTVQPSAASNL |
| DNA Sequence | >LmjF31.0560 |||mevalonate kinase, putative|Leishmania major|chr 31|||Manual ATGTCGAAGC CCGTCAAGAG CAAGACAACC GGCAAGAACA TCGGCTATGG CAAAGTGATTCTCTTTGGTG AGCACTTTGT CGTGCACGGT GCCGAAGCCA TTGTTGCCGG TATCAGTGAGTATACGGAGT GCCGCCTGGA GATTAATCCC GGCGTCCCCG GACTGCAGGT GGACGACCAGCGCCCTGCTA TCCCCGGCTA CATTGCACAG AAGCGCGACG AGCAGATAAA GGCACATCAGCTCGTCCTCG ATCACCTGAA GGTGGACCTG TCTGGGGATG GGCTGAAGAT GTTCATTGGCGGACCACTGG TACCGAGCAG TGGCATTGGT GCCTCCGCCA GTGACGTCGT GGCCTTCTCGCGCGCCTTGA GTGAGTTATA CCAGCTGAAC TTGACGGATG AAGAGGTGAA TCTGAGCGCATTTGTCGGTG AGGGCGGCTA TCACGGCACG CCGAGTGGGG CTGATAACAC GGCTGCAACGTATGGCGGAC TCATTTTGTA CCGTCGCCAA AACGGCAAAA GTGTCTTCAA GCCCATCGCATTCCAGCAGC GCCTCTACCT GGTCGTCGTG GGCACCGGTA TCAATGCCAG CACGGCGAAGGTTGTCAATG ACGTGCACAA GATGAAGCAG CAGCAGCCAG TGCAGTTCAA GCGACTGTACGATAACTACA CCCACATCGT CTCCCAGGCT CGTGAGGCCT TGCAGAAGGG TGACCTCCAGCGGTTAGGGC AGCTGATGAA TGCCAACCAC GATCTGTGCC GCCAGATCGA CGTATCGTGTCGTGAGTTGG AGTCGATTGT GCAGACGTGC CGCACTTATG GTGCTCTTGG CGCGAAGCTGTCCGGCACCG GCCGTGGCGG CATTGCCGTA GCCTTGGCGG CGTCAAGTGA CCAGCGCGATGCCATTGTGA AAGGCCTCAA GGCGAAGTGC CCCGAAGCTA AGTTTATTTG GAGGTATACAGTACAGCCGT CCGCCGCGTC GAACCTATAA |
| Mevalonate kinase, putative Q4Q6K7] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; kinase activity; mevalonate kinase activity; phosphotransferase activity, alcohol group as acceptor |
| Biochemical Pathway | isoprenoid biosynthesis; metabolism; phosphorylation |
| Regulatory Pathway | |
| KEGG Pathways | K00869 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | mevalonate kinase [Homo sapiens] | 24 | 0.00000000008 | 65 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| mvk Mevalonate kinase | Streptococcus pneumoniae | 26% | 6e-21 | 95.5 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 130-133; 137-140; 195-198; 222-225; | PS00722 | |
| Acylation | N-myristoylation site | 108-113; 110-115; 145-150; 149-154; 153-158; 191-196; 193-198; 243-248; 274-279; 277-282; 282-287; 287-292; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 112-115; 132-135; 152-155; 259-262; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 10-12; 198-200; 259-261; 269-271; 283-285; | PS00005 | |
| Mevalonate kinase, putative [Q4Q6K7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2hfuB | |
| Percent Identity | 100% | |
| Target Region | 1-329 | |
| Template Region | 1-325 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 18 | Sidechain |
| ASP | 155 | Sidechain |
| THR | 198 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| (R)-MEVALONATE | 147.149 | C6 H11 O4 | O=C([O-])CC(O)(C)CCO | 2hfu | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/951800/Q4Q6K7.pdb 2.0 329 = residues | | = | *| Ramachandran plot: 94.3% core 5.3% allow 0.0% gener 0.4% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 327) = | | Chi1-chi2 plots: 0 labelled residues (out of 183) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 4.0 Bad contacts: = 0 | +| Bond len/angle: 4.9 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.22 Covalent: -0.07 Overall: = 0.11 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 95.3% within limits 4.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |