| Serine/threonine protein phosphatase pp1(5.9), putative [Q4Q5Z8] | |
|---|---|
| Systematic Name | LmjF.31.2630 [Leishmania major] |
| Gene Name | LMJF_31_2630 |
| Molecular Weight | 40766 Da |
| Protein Sequence Size | 365 |
| Function | |
| Charge | -10.5 |
| Isoelectric Point | 4.7749 pH |
| Description | Serine/threonine protein phosphatase pp1(5.9), putative (EC 3.1.3.16). |
| Subcellular Location | nucleus[Predict] |
| E. C. Number | 3.1.3.16 |
| Sequence | >tr|Q4Q5Z8|Q4Q5Z8_LEIMA Serine/threonine protein phosphatase pp1(5.9), putative (EC 3.1.3.16) - Leishmania major. IGLSKAEVIIGKLLLNPAHNTAALKRDANSPLSSFSRQSRLQAFQAETAAAVAAAAPKAD SANRTGRTRGLSSSSISDPREFATGEMTEEEVVYLVMESRKLFMSQPMLIEIEAPVNVCG DVHGQYHDLLRLFELGGYPPDSNYIFLGDYVDRGEQSLETVCLLLAYKLNFPNNFFLLRG NHESSSINRIYGFFDECKRRYSVKLWKLFTDTFNCMPVAGLINGRILCMHGGLSPELHSL DQIRRILRPSDVPDSGLICDLLWSDPADDPIIGFGENDRGVSWTFGENVVENITQALDLD LICRAHQVAEEGYKFFAKRKLLTVFSAPNYCGEFNNYGAFLCVDENLMCSVKQLVPLFEV DDFE |
| DNA Sequence | >LmjF31.2630 |||serine/threonine protein phosphatase pp1(5.9), putative|Leishmania major|chr 31|||Manual ATGATTGGGC TTTCAAAGGC AGAGGTCATT ATCGGCAAGC TGCTGCTGAA CCCGGCCCACAACACCGCCG CGCTGAAACG AGATGCGAAT AGCCCTCTCT CGTCTTTTTC AAGGCAGTCGCGGCTGCAGG CCTTCCAGGC AGAGACGGCA GCTGCGGTTG CGGCTGCGGC ACCCAAGGCAGATTCGGCCA ATCGCACCGG TCGCACTCGA GGCCTCAGCA GTAGCAGCAT TTCCGACCCGCGGGAGTTCG CGACGGGGGA GATGACGGAG GAAGAGGTGG TGTACCTCGT GATGGAGTCGCGAAAGTTGT TCATGTCGCA GCCGATGCTG ATTGAGATAG AGGCCCCGGT GAACGTGTGTGGTGATGTAC ACGGACAGTA TCACGACCTG CTGCGCCTCT TCGAGCTTGG CGGCTACCCGCCGGATAGTA ACTACATCTT CCTCGGCGAT TACGTTGACC GTGGTGAGCA GTCACTAGAAACCGTTTGTC TGCTGCTCGC CTACAAGCTG AACTTCCCCA ACAACTTTTT CCTTCTCCGTGGCAACCATG AGAGCAGCAG CATCAATCGC ATCTACGGCT TCTTCGACGA GTGCAAGCGCCGCTACAGCG TAAAGCTCTG GAAGCTCTTT ACTGACACCT TCAACTGCAT GCCGGTAGCTGGTCTCATCA ACGGACGCAT TCTGTGCATG CACGGCGGCC TTAGTCCAGA GCTGCACAGCCTAGATCAAA TCCGTCGCAT CCTGCGTCCA TCTGACGTGC CGGATAGCGG TCTCATCTGCGACCTGCTCT GGTCGGACCC CGCCGATGAC CCGATCATCG GCTTTGGCGA GAACGACCGCGGCGTGTCAT GGACGTTTGG CGAGAACGTG GTGGAGAACA TCACTCAGGC GCTGGACCTGGACCTAATCT GCCGCGCGCA CCAGGTTGCC GAAGAGGGCT ACAAGTTCTT CGCGAAGCGAAAACTTCTGA CCGTTTTCTC GGCCCCCAAC TACTGTGGCG AGTTCAACAA CTACGGGGCCTTCCTGTGCG TCGATGAAAA CCTCATGTGC AGCGTGAAGC AGCTCGTGCC GCTCTTCGAGGTGGACGACT TCGAGTGA |
| Serine/threonine protein phosphatase pp1(5.9), putative Q4Q5Z8] | |
|---|---|
| Metabolite Information | protein amino acid dephosphorylation |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01090 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 1, catalytic subunit, alpha isoform 3 [Homo sapiens] | 67 | 1e-116 | 414 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER133w serthr phosphoprotein phosphatase 1, catalytic chain | Saccharomyces cerevisiae | 65% | 1e-116 | 412 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 64-67; 293-296; | PS00722 | |
| PDOC00115 | Serine/threonine specific protein phosphatases signature | 179-184; | PS00125 | |
| Acylation | N-myristoylation site | 3-8; 71-76; 181-186; 221-226; 281-286; 339-344; | PS00008 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 200-203; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 5-8; 76-79; 89-92; 285-288; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 66-68; 100-102; 203-205; 351-353; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 132-139; | PS00007 | |
| Serine/threonine protein phosphatase pp1(5.9), putative [Q4Q5Z8] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1fjmB | |
| Percent Identity | 67% | |
| Target Region | 1-365 | |
| Template Region | 7-289 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 153 | Sidechain |
| HIS | 183 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 60-24-2 | BETA-MERCAPTOETHANOL | 78.133 | C2 H6 O S | OCCS | 1fjm |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 1fjm |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/280938/Q4Q5Z8.pdb 2.0 365 = residues | | = | *| Ramachandran plot: 92.5% core 5.3% allow 1.2% gener 0.9% = disall | | = | +| All Ramachandrans: 7 labelled residues (out of 363) = | +| Chi1-chi2 plots: 2 labelled residues (out of 224) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 2 | *| Bond len/angle: 8.3 Morris et al class: 1 = 1 2 | +| 3 cis-peptides = | | G-factors Dihedrals: 0.04 Covalent: -0.19 Overall: = -0.05 | | = | | M/c bond lengths: 99.2% within limits 0.8% highlighted = | *| M/c bond angles: 93.6% within limits 6.4% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |