| Iron superoxide dismutase, putative [Q4Q596] | |
|---|---|
| Systematic Name | LmjF.32.1830 [Leishmania major] |
| Gene Name | SODB2 |
| Molecular Weight | 22980 Da |
| Protein Sequence Size | 208 |
| Function | Destroys radicals which are normally produced within the cells and which are toxic to biological systems |
| Charge | 7.5 |
| Isoelectric Point | 7.9729 pH |
| Description | Iron superoxide dismutase, putative (EC 1.15.1.1). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 1.15.1.1 |
| Sequence | >tr|Q4Q596|Q4Q596_LEIMA Iron superoxide dismutase, putative (EC 1.15.1.1) - Leishmania major. PFAAQPLPYPHDALASKGMSKEQVTFHHEKHHKGYAVKLTAAAESNSALASKSLVDIIKS EKGPAFNCAAQIYNHDFFWRCLSPRGGSKPHGEIASAIIDSFGSFSNFKKEFTAAANGHF GSGWAWLVKDKSSGKLKVFQTHDAGCPLTEPDLVPILACDVWEHAYYIDYRNDRASYVSA FWNMVNWSHANHCYRAAGGAHYVNSDL |
| DNA Sequence | >LmjF32.1830 |SODB2||iron superoxide dismutase, putative|Leishmania major|chr 32|||Manual ATGCCGTTCG CTGCTCAGCC GCTGCCGTAC CCCCACGACG CGCTCGCGTC GAAGGGCATGTCGAAGGAGC AGGTCACCTT CCACCACGAG AAGCATCATA AGGGGTACGC CGTGAAGCTGACCGCTGCCG CGGAGTCGAA CTCGGCTCTT GCGTCGAAGT CGCTGGTGGA CATCATCAAGTCTGAGAAGG GCCCCGCCTT CAACTGTGCG GCGCAGATTT ACAACCACGA CTTCTTCTGGCGCTGCCTCT CGCCACGCGG CGGGTCAAAA CCGCACGGAG AGATCGCGAG CGCGATCATCGACAGTTTCG GCAGCTTCTC GAATTTCAAG AAGGAATTCA CGGCTGCGGC CAACGGCCACTTTGGCTCGG GCTGGGCGTG GCTCGTGAAG GACAAGTCGA GTGGCAAGCT GAAGGTGTTCCAAACGCACG ACGCGGGCTG CCCGCTCACG GAGCCCGACC TCGTACCGAT CTTGGCGTGTGATGTATGGG AGCACGCGTA CTATATCGAC TACAGGAACG ACCGCGCGTC CTACGTGAGCGCGTTTTGGA ACATGGTGAA TTGGTCGCAC GCCAACCACT GCTACAGGGC CGCTGGCGGCGCCCACTACG TCAACAGTGA TCTGTAA |
| Iron superoxide dismutase, putative Q4Q596] | |
|---|---|
| Metabolite Information | superoxide metabolism |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K04564 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | manganese superoxide dismutase isoform A precursor [Homo sapiens] | 40 | 2e-35 | 145 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YOR250c cleavagepolyadenylation factor IA subunit | Saccharomyces cerevisiae | 36% | 1.9 | 26.6 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 187-190; | PS00722 | |
| PDOC00083 | Manganese and iron superoxide dismutases signature | 161-168; | PS00088 | |
| Acylation | N-myristoylation site | 104-109; 122-127; 146-151; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 54-57; 150-153; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 61-63; 84-86; 134-136; | PS00005 | |
| Iron superoxide dismutase, putative [Q4Q596] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2gpcB | |
| Percent Identity | 65% | |
| Target Region | 1-195 | |
| Template Region | 1-193 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| FE (II) ION | 55.845 | Fe | [Fe+2] | 2gpc | |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 2gpc |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1316007/Q4Q596.pdb 2.0 195 = residues | | = | *| Ramachandran plot: 96.5% core 1.8% allow 1.2% gener 0.6% = disall | | = | +| All Ramachandrans: 2 labelled residues (out of 193) = | +| Chi1-chi2 plots: 1 labelled residues (out of 110) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 11.2 Bad contacts: = 1 | *| Bond len/angle: 12.6 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.13 Covalent: -0.30 Overall: = -0.03 | | = | *| M/c bond lengths: 98.5% within limits 1.5% highlighted 2 off = graph | *| M/c bond angles: 93.0% within limits 7.0% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |