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Chaperonin Hsp60, mitochondrial, putative [Q4Q594]
Systematic NameLmjF.32.1850 [Leishmania major]
Gene NameLMJF_32_1850
Molecular Weight64309 Da
Protein Sequence Size594
Function
Charge-0.5
Isoelectric Point6.3744 pH
DescriptionChaperonin Hsp60, mitochondrial, putative.
Subcellular Locationmitochondrial matrix; Mitochondrion[Predict]
E. C. Number N.A.
Sequence>tr|Q4Q594|Q4Q594_LEIMA Chaperonin Hsp60, mitochondrial, putative - Leishmania major.
LSRTVPRCVKYGSTPKDIRYGMEARNALLAGVENLVKAVGVTLGPKGRNVILEMPYACPK
ITKDGVTVAKSIEFEDSFENLGANLVRQVAGLTNDNAGDGTTTATVLSGAIFKEGFRSVA
SGTNPMDLKRGIDLACREVLISLAEQSRPVTSKSEITQVAMISANMDQEIGSLIGDAMQQ
VGKDGVITTQEGRSLNTELELVEGMSFERGYTSPYFVTNTKAQRCELENALVYVANRKLT
SVAHILPALNYAIQQKRPLLVIAEDVEGEAMHTFLYNKIQGRISGCAVKAPGFGDMRINQ
LQDIAVFTGSQMISEDLGLSLDQNDFSERFLGTCRKVTVSRDECILMEGGGSAIAVEERV
QMIKDMISAEDHEYNRERLVERLAKLSGGVAVIKVGGASEVEINEKKDRIIDALNATRAA
VSEGILAGGGTGLLMASLRLESISKDRRLPPDIRTGVNIVKKAIGLPARYIANNAGVEGS
VVAGKVLARKDPSFGYNAQTGEYVNMFEAGIIDPMKVVKSAVVNACSVAGMMITTEAAVV
EKDLLGREKRIEDEGMEDKEKKRSVDKLRKQVNERDAPMPKMAPPMKFDMKGL
DNA Sequence>LmjF32.1850 |||chaperonin Hsp60, mitochondrial precursor, putative|Leishmania major|chr 32|||Manual
ATGCTCTCCC GTACGGTGCC TCGCTGTGTC AAGTACGGCT CAACGCCGAA GGACATCCGCTATGGCATGG AGGCCCGCAA CGCCCTGCTT GCCGGCGTCG AGAACCTTGT CAAGGCCGTCGGCGTCACGC TGGGCCCCAA GGGCCGCAAC GTGATTCTGG AGATGCCATA CGCATGCCCGAAGATCACGA AGGATGGAGT CACGGTGGCC AAGAGCATCG AGTTCGAGGA CAGCTTCGAGAACCTTGGGG CGAACTTGGT CCGTCAGGTG GCAGGGCTGA CCAACGACAA CGCCGGTGACGGCACCACCA CCGCTACTGT CCTCTCCGGG GCGATCTTCA AGGAGGGCTT CCGCAGCGTTGCAAGTGGCA CGAACCCGAT GGACCTGAAG CGGGGCATCG ACCTCGCATG CCGGGAGGTGCTCATATCGC TGGCCGAGCA GTCTCGCCCA GTCACCTCCA AATCTGAGAT CACCCAGGTAGCGATGATTT CGGCGAACAT GGACCAAGAG ATCGGCAGCC TGATCGGTGA CGCGATGCAGCAGGTCGGCA AGGATGGCGT AATCACAACG CAGGAGGGTC GCTCGCTTAA TACGGAGCTCGAGCTGGTCG AGGGGATGTC CTTTGAGCGT GGGTACACGT CGCCGTACTT TGTGACGAACACGAAGGCGC AAAGGTGCGA GCTCGAGAAC GCCCTCGTCT ACGTGGCGAA CCGCAAACTCACGAGCGTGG CGCACATCTT GCCCGCGCTG AACTACGCCA TTCAGCAGAA GCGTCCGCTTCTGGTGATTG CCGAGGACGT GGAGGGGGAG GCCATGCACA CGTTCCTGTA CAACAAGATTCAGGGCCGCA TCAGTGGCTG CGCCGTCAAG GCCCCGGGCT TTGGCGACAT GCGCATCAACCAGCTGCAGG ATATCGCCGT CTTCACGGGG TCGCAGATGA TCTCAGAAGA CCTAGGCCTTTCACTGGACC AGAACGATTT CTCCGAGCGG TTCCTCGGCA CTTGTCGAAA GGTGACCGTCTCCCGTGACG AGTGCATCTT GATGGAGGGC GGCGGCAGCG CCATCGCGGT GGAGGAGCGAGTGCAGATGA TCAAAGACAT GATCTCCGCC GAGGACCACG AATACAATCG CGAGCGTCTGGTCGAGCGTC TCGCGAAGCT CTCGGGTGGG GTTGCGGTGA TCAAGGTCGG TGGCGCCTCGGAGGTGGAGA TCAATGAGAA GAAGGACCGC ATCATCGACG CGCTCAACGC CACGCGCGCGGCTGTATCAG AGGGCATCCT CGCAGGTGGT GGCACCGGGT TGCTTATGGC CTCTCTGCGTCTCGAGAGCA TCTCCAAGGA CCGACGACTT CCACCTGACA TCCGCACTGG CGTGAACATTGTGAAGAAGG CAATCGGCCT GCCCGCGCGC TACATCGCGA ACAACGCAGG CGTCGAGGGCAGCGTGGTGG CGGGGAAGGT ACTCGCGCGC AAGGATCCGA GCTTCGGCTA CAACGCGCAGACCGGCGAGT ATGTGAATAT GTTCGAGGCT GGCATTATCG ATCCCATGAA AGTAGTGAAGTCCGCCGTCG TCAACGCATG CTCCGTGGCG GGCATGATGA TTACGACGGA GGCGGCAGTGGTGGAGAAGG ACCTGCTAGG GCGAGAGAAA CGCATCGAGG ATGAGGGGAT GGAGGACAAGGAGAAGAAGC GCAGCGTCGA CAAACTGCGC AAGCAGGTAA ATGAGCGGGA CGCACCGATGCCCAAGATGG CGCCGCCGAT GAAGTTTGAT ATGAAAGGGC TGTAG
Chaperonin Hsp60, mitochondrial, putative Q4Q594]
Metabolite Informationcellular protein metabolism; protein complex assembly; protein folding; protein import into mitochondrial matrix
Molecular Function
Biochemical Pathway
Regulatory Pathway
KEGG PathwaysK04077
Orthologs
Homologs GI Percent Identity Evalue Score
Homo sapienschaperonin [Homo sapiens]491e-148522
DEG Information
DEG Protein DEG Organism Percent Identity Evalue Bit Score
YLR259c heat shock protein - chaperone, mitochondrialSaccharomyces cerevisiae51%1e-151529
Post Translational Modification
PTM Type PTM Sub Type Score Modification Site Prosite ID
PDOC00015The rule PS00015 has been deleted from the PROSITE database and replaced by the following motif: PS50079 (Bipartite nuclear localization signal profile550-566; PS00015
AcylationN-myristoylation site66-71; 101-106; 132-137; 172-177; 186-191; 350-355; 352-357; 425-430; 429-434; 433-438; 477-482; 480-485; 531-536; PS00008
GlycosylationN-glycosylation site416-419; PS00001
PhosphorylationcAMP- and cGMP-dependent protein kinase phosphorylation site238-241; 336-339; 562-565; PS00004
PhosphorylationCasein kinase II phosphorylation site15-18; 143-146; 153-156; 189-192; 198-201; 341-344; 369-372; 400-403; PS00006
PhosphorylationProtein kinase C phosphorylation site15-17; 152-154; 328-330; 334-336; 438-440; PS00005
Chaperonin Hsp60, mitochondrial, putative [Q4Q594]
Model Information
Template PDB ID1iokG
Percent Identity51%
Target Region15-544
Template Region2-482
Domain Information
Domains Start End
Active Site Information
Residue Active Site Number Functional Part
ASP51Sidechain
THR88Sidechain
THR89Sidechain
ASP399Sidechain
Co-Factor
Metal Description
Ligands
CAS number Name Mol. Weight Mol. Formula Smile Notation PDB Reference
Mutational Information
Residue Feature Description
Modeled Protein Template Structure
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2805264/Q4Q594.pdb 2.0 530 = residues | | = | *| Ramachandran plot: 91.4% core 7.6% allow 0.6% gener 0.4% = disall | | = | +| All Ramachandrans: 14 labelled residues (out of 528) = | +| Chi1-chi2 plots: 5 labelled residues (out of 294) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 9.2 Bad contacts: = 11 | *| Bond len/angle: 6.9 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.05 Covalent: -0.13 Overall: = -0.02 | | = | | M/c bond lengths: 99.2% within limits 0.8% highlighted = | | M/c bond angles: 94.6% within limits 5.4% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further.
Overlapped Structure Procheck Summary
LeishBase: Leishmania Structural Database
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