| Ras-related protein rab-2a, putative [Q4Q573] | |
|---|---|
| Systematic Name | LmjF.32.2030 [Leishmania major] |
| Gene Name | LMJF_32_2030 |
| Molecular Weight | 23279 Da |
| Protein Sequence Size | 211 |
| Function | |
| Charge | 2.5 |
| Isoelectric Point | 7.8589 pH |
| Description | Ras-related protein rab-2a, putative. |
| Subcellular Location | Attached to the cytoplasmic side of the membrane by a lipid-anchor[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q573|Q4Q573_LEIMA Ras-related protein rab-2a, putative - Leishmania major SQSNYVFKYIIIGDSGVGKSCLLLQFTDKRFEPLHDLTIGVEFGARLISIQGKSVKLQIW DTAGQESFRSITRSYYRGASGALLVYDVTRRDTFTHLQSWLEDAKANANTALVIMLIGNK CDLESKRQVSREEGEAFARCNGLMFMETSAKTSQNVDDAFLQTAALIYDNVQLGMIDASV VSGRPGTQANNSRLQNAHANNNNRSSGCTC |
| DNA Sequence | >LmjF32.2030 |||ras-related protein rab-2a, putative|Leishmania major|chr 32|||Manual ATGTCGCAGA GCAACTACGT GTTCAAATAC ATCATTATCG GCGACAGCGG CGTCGGCAAGAGCTGTCTGC TGCTCCAGTT CACCGACAAG CGCTTCGAGC CGTTACACGA CTTGACCATCGGCGTAGAGT TTGGGGCGCG GCTCATCTCC ATCCAAGGCA AGAGTGTCAA GCTGCAGATTTGGGATACGG CTGGGCAGGA GAGCTTCCGT AGCATCACCC GTAGCTACTA CCGCGGCGCTAGCGGGGCTC TGCTCGTCTA CGACGTCACC CGACGAGATA CCTTCACGCA CCTGCAGAGTTGGCTGGAGG ATGCCAAGGC AAACGCGAAC ACGGCACTTG TGATTATGCT GATTGGTAACAAGTGCGACC TCGAGAGCAA GCGCCAGGTG AGCCGCGAGG AAGGAGAGGC GTTTGCGCGCTGCAACGGGC TGATGTTTAT GGAAACGAGC GCCAAGACAT CGCAGAACGT CGACGATGCTTTCCTGCAGA CGGCAGCGCT CATCTACGAC AACGTGCAGC TCGGTATGAT CGATGCGTCTGTCGTCTCTG GACGTCCAGG GACGCAGGCG AACAACTCGC GTTTGCAGAA TGCGCATGCCAACAACAACA ACAGAAGCAG CGGGTGCACG TGCTAA |
| Ras-related protein rab-2a, putative Q4Q573] | |
|---|---|
| Metabolite Information | intracellular protein transport; protein transport; small GTPase mediated signal transduction |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K07878 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | RAB2, member RAS oncogene family [Homo sapiens] | 66 | 1e-75 | 279 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YFL005w GTP-binding protein of the ras superfamily | Saccharomyces cerevisiae | 44% | 6e-45 | 174 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 14-21; | PS00017 | |
| PDOC00579 | Sigma-54 interaction domain signatures and profile | 10-23; | PS00675 | |
| Acylation | N-myristoylation site | 17-22; 41-46; 79-84; 175-180; 187-192; | PS00008 | |
| Glycosylation | N-glycosylation site | 191-194; 204-207; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 91-94; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 90-93; 100-103; 131-134; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 28-30; 55-57; 68-70; 90-92; 126-128; 150-152; 183-185; | PS00005 | |
| Ras-related protein rab-2a, putative [Q4Q573] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2a5jA | |
| Percent Identity | 73% | |
| Target Region | 1-180 | |
| Template Region | 1-175 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| GLN | 66 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 146-91-8 | GUANOSINE-5'-DIPHOSPHATE | 443.201 | C10 H15 N5 O11 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O | 2a5j |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 2a5j |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2462645/Q4Q573.pdb 2.0 175 = residues | | = | +| Ramachandran plot: 91.2% core 8.1% allow 0.6% gener 0.0% = disall | | = | +| All Ramachandrans: 3 labelled residues (out of 173) = | +| Chi1-chi2 plots: 1 labelled residues (out of 108) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 5.4 Bad contacts: = 1 | *| Bond len/angle: 6.1 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.07 Covalent: -0.09 Overall: = 0.01 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 94.3% within limits 5.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |