| Pyrroline-5-carboxylate synthetase-like protein [Q4Q4V8] | |
|---|---|
| Systematic Name | LmjF.32.3140 [Leishmania major] |
| Gene Name | LMJF_32_3140 |
| Molecular Weight | 50730 Da |
| Protein Sequence Size | 479 |
| Function | |
| Charge | -4 |
| Isoelectric Point | 6.1 pH |
| Description | Pyrroline-5-carboxylate synthetase-like protein. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q4V8|Q4Q4V8_LEIMA Pyrroline-5-carboxylate synthetase-like protein - Leishmania major. ASAEAEVAADMSAMWRYAEEARAGSSALSDLTYAERQAMLRAVAKALQTNEARILEANRE DMVAAKANATADPLLRRLELTPSKLATLIEGISTLADMPDPIGQILSARELDNNLLLLKQ TAPIGVVLVVFESRPESLPQIASLALCSGNGLLLKGGREGEHSNAVLHDLIVSAVESSTQ GRVPRGVIGLVTNRADVYSLLQLDAHIDLVVPRGSNAMVQNIQRSTRIPVLGHADGICHV YVHKDADVDAALAVAIDAKLNYPAACNAAETLLLHRDLLHSPAHGTTAAQFLVNGMTEAG VSFYAGPQAIAAGLASELAASLHMEYGDAHMTVEVVDDLAAAIAHVNRHGSHHTDTILTV DKAAAAEFQRRVESACVFHNCSTRFADGFRFGLGAEVGISTARIHARGPVGVEGLLTQKW VLKPMGSLPQATEDGAAAAAANAPYATVAEFQKGQRVFTHKDVTRKLQDEAAGLRLQA |
| DNA Sequence | >LmjF32.3140 |||pyrroline-5-carboxylate synthetase-like protein|Leishmania major|chr 32|||Manual ATGGCGTCCG CAGAAGCGGA GGTCGCAGCA GACATGTCGG CGATGTGGCG CTACGCAGAGGAGGCACGCG CCGGTTCCTC TGCCCTGAGC GATCTCACTT ACGCTGAGCG GCAGGCGATGCTGCGCGCGG TGGCCAAGGC GCTGCAGACG AACGAGGCCC GCATTCTCGA AGCGAATCGGGAAGACATGG TGGCGGCGAA AGCGAACGCC ACTGCAGACC CGCTGTTGAG GCGGTTGGAGCTGACGCCGA GCAAGCTGGC CACGCTGATA GAGGGAATCT CGACCTTGGC GGACATGCCGGACCCAATCG GGCAGATTCT TTCGGCTCGT GAGCTGGACA ACAACCTGCT GCTGCTGAAGCAGACGGCCC CGATTGGGGT GGTACTAGTT GTATTTGAGT CCCGCCCTGA AAGTCTCCCGCAGATCGCCT CTCTCGCCCT CTGCTCCGGA AACGGGCTTC TTCTCAAGGG TGGGCGCGAGGGGGAGCACT CGAACGCGGT GCTGCATGAC TTGATCGTCT CAGCTGTGGA GTCCAGCACACAGGGACGCG TGCCGCGAGG GGTAATCGGC CTCGTTACGA ATCGCGCTGA CGTATACAGCCTTCTGCAGC TGGATGCGCA CATTGATCTC GTCGTGCCTC GCGGAAGCAA CGCGATGGTGCAAAACATCC AGCGCTCCAC TCGCATTCCG GTGCTGGGTC ACGCCGATGG CATCTGCCACGTATACGTGC ACAAGGACGC AGATGTGGAC GCGGCGCTGG CGGTGGCGAT CGATGCGAAGCTGAATTATC CGGCAGCGTG CAACGCGGCA GAAACGCTGC TGCTGCACCG CGATCTTCTCCACTCCCCCG CGCATGGTAC CACAGCGGCG CAGTTCCTTG TCAATGGCAT GACGGAGGCGGGTGTGTCCT TCTACGCCGG TCCGCAGGCC ATCGCTGCGG GGCTGGCAAG TGAGCTGGCGGCTTCTCTTC ACATGGAGTA CGGCGATGCG CACATGACAG TGGAGGTTGT CGATGACTTGGCGGCGGCTA TCGCGCACGT GAACCGGCAC GGCTCGCACC ACACAGACAC CATTCTCACCGTTGACAAGG CTGCCGCAGC GGAGTTTCAG CGGCGGGTTG AGAGCGCCTG TGTGTTCCACAACTGCTCTA CTCGCTTCGC TGACGGGTTC AGGTTCGGCC TCGGTGCGGA GGTGGGCATCAGCACCGCCC GCATTCACGC TCGCGGCCCA GTCGGTGTTG AGGGACTGCT GACCCAAAAGTGGGTCTTGA AGCCGATGGG GTCGTTGCCT CAGGCGACGG AGGACGGCGC CGCTGCAGCTGCGGCCAACG CGCCGTACGC GACGGTGGCG GAGTTCCAGA AGGGGCAGCG TGTCTTCACTCACAAGGATG TCACCCGCAA GCTTCAGGAT GAGGCCGCAG GGCTGCGATT GCAGGCTTGA |
| Pyrroline-5-carboxylate synthetase-like protein Q4Q4V8] | |
|---|---|
| Metabolite Information | proline biosynthesis |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K00147 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | pyrroline-5-carboxylate synthetase isoform 2 [Homo sapiens] | 45 | 3e-90 | 329 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| glnH PROBABLE GLUTAMINE-BINDING LIPOPROTEIN GLNH (GLNBP) | Mycobacterium tuberculosis H37Rv | 43% | 2 | 28.1 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00135 | Arginase family signatures | 201-209; | PS00148 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 69-72; 381-384; | PS00722 | |
| Acylation | N-myristoylation site | 104-109; 157-162; 190-195; 286-291; 296-301; 351-356; 395-400; 399-404; 436-441; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 33-36; 88-91; 95-98; 108-111; 134-137; 174-177; 448-451; 460-463; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 108-110; 193-195; 226-228; 383-385; 402-404; 418-420; 460-462; 465-467; | PS00005 | |
| Pyrroline-5-carboxylate synthetase-like protein [Q4Q4V8] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2h5gB | |
| Percent Identity | 45% | |
| Target Region | 14-481 | |
| Template Region | 362-425 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S | [O-]S([O-])(=O)=O | 2h5g |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/610194/Q4Q4V8.pdb 2.0 466 = residues | | = | *| Ramachandran plot: 92.0% core 7.0% allow 0.5% gener 0.5% = disall | | = | *| All Ramachandrans: 14 labelled residues (out of 464) = | +| Chi1-chi2 plots: 1 labelled residues (out of 246) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 4 | *| Bond len/angle: 10.1 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.05 Covalent: -0.17 Overall: = -0.03 | | = | | M/c bond lengths: 99.0% within limits 1.0% highlighted = | *| M/c bond angles: 93.7% within limits 6.3% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |