| Glucosamine-6-phosphate isomerase, putative [Q4Q4U6] | |
|---|---|
| Systematic Name | LmjF.32.3260 [Leishmania major] |
| Gene Name | LMJF_32_3260 |
| Molecular Weight | 31524 Da |
| Protein Sequence Size | 279 |
| Function | |
| Charge | 3 |
| Isoelectric Point | 7.2341 pH |
| Description | Glucosamine-6-phosphate isomerase, putative (Glucosamine-6-phosphate deaminase, putative) (EC 3.5.99.6). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.5.99.6 |
| Sequence | >tr|Q4Q4U6|Q4Q4U6_LEIMA Glucosamine-6-phosphate isomerase, putative (Glucosamine-6-phosphate deaminase, putative) (EC 3.5.99.6) - Leishmania major. RIVISETAEKVADYTSNYVIKSINDFKPTEDRPFVLGLPTGETPMRTYQKLIVAYRKGRV SFKNVITFNMDEYVGLPADHPESYHYFMKHNFFDYVDIPEQNRHILDGNAPDLIEECRQY EEKIRAVGGIHLFLAGIGTDGHLAFNEPGSSLYSRTRVKSLNAETMESNARFFGNDVSRV PTMALTVGLRTIMEAKFVLMMATGAGKALAVARCVEGGITHMCTATMLQMHPAAVLCLDE DATLELKVRTTRYFKQLLNTEKALEERQSNMNRAYSKL |
| DNA Sequence | >LmjF32.3260 |||glucosamine-6-phosphate isomerase, putative|Leishmania major|chr 32|||Manual ATGCGGATCG TGATCTCCGA GACGGCGGAA AAGGTGGCGG ACTACACGTC TAATTACGTGATCAAGTCCA TCAACGATTT CAAGCCGACG GAAGACCGGC CGTTTGTGCT TGGGCTGCCGACGGGCGAGA CGCCGATGCG CACGTACCAG AAACTGATCG TTGCGTACCG CAAGGGCCGCGTGTCCTTCA AGAACGTGAT CACGTTCAAC ATGGACGAGT ACGTGGGACT ACCAGCGGACCACCCGGAGA GCTACCACTA CTTCATGAAG CACAACTTCT TCGACTACGT AGACATCCCCGAGCAGAACC GGCACATCCT GGACGGGAAC GCGCCGGATT TGATTGAGGA GTGCCGTCAGTACGAGGAGA AGATTCGGGC TGTTGGCGGC ATCCACCTGT TCCTCGCCGG GATTGGGACGGACGGACACC TTGCGTTCAA CGAGCCGGGG AGCAGCCTCT ACAGCCGCAC GCGCGTCAAGAGCCTGAACG CGGAGACGAT GGAGAGCAAC GCGCGGTTCT TTGGCAACGA CGTCTCGCGCGTGCCGACGA TGGCGCTAAC GGTTGGGCTG CGCACGATCA TGGAGGCCAA GTTTGTGCTGATGATGGCCA CTGGTGCCGG CAAGGCTCTC GCGGTCGCAC GGTGTGTGGA GGGCGGGATCACACACATGT GCACTGCAAC GATGCTACAG ATGCACCCCG CCGCAGTGCT GTGCCTTGACGAGGACGCGA CCCTCGAGCT GAAGGTGCGG ACGACGCGCT ACTTCAAGCA GCTGCTGAACACGGAGAAAG CGCTGGAGGA GCGCCAGAGC AACATGAATC GTGCCTATTC GAAGCTGTAG |
| Glucosamine-6-phosphate isomerase, putative Q4Q4U6] | |
|---|---|
| Metabolite Information | N-acetylglucosamine catabolism; N-acetylglucosamine metabolism; carbohydrate metabolism |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K02564 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | glucosamine-6-phosphate deaminase 1 [Homo sapiens] | 55 | 1e-81 | 300 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| nagB glucosamine-6-phosphate isomerase | Haemophilus influenzae | 55% | 6e-84 | 304 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00894 | Glucosamine/galactosamine-6-phosphate isomerases signature | 125-143; | PS01161 | |
| PDOC00299 | Microbodies C-terminal targeting signal | 277-279; | PS00342 | |
| Acylation | N-myristoylation site | 38-43; 175-180; 205-210; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 23-26; 192-195; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 62-64; 251-253; 261-263; | PS00005 | |
| Glucosamine-6-phosphate isomerase, putative [Q4Q4U6] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1hotB | |
| Percent Identity | 57% | |
| Target Region | 1-279 | |
| Template Region | 1-266 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 72 | Sidechain |
| ASP | 141 | Sidechain |
| HIS | 143 | Sidechain |
| GLU | 148 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14265-44-2 | PHOSPHATE ION | 94.971 | O4 P | [O-]P([O-])([O-])=O | 1hot |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/895132/Q4Q4U6.pdb 2.0 279 = residues | | = | +| Ramachandran plot: 93.6% core 6.0% allow 0.4% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 277) = | +| Chi1-chi2 plots: 1 labelled residues (out of 171) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.6 Bad contacts: = 2 | *| Bond len/angle: 5.8 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.10 Covalent: -0.19 Overall: = -0.01 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 92.5% within limits 7.5% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |