| Heat shock protein 83-1 [Q4Q4I0] | |
|---|---|
| Systematic Name | LmjF.33.0318 [Leishmania major] |
| Gene Name | HSP83-8 |
| Molecular Weight | 80406 Da |
| Protein Sequence Size | 700 |
| Function | Molecularchaperone. Has ATPase activity |
| Charge | -23 |
| Isoelectric Point | 4.8105 pH |
| Description | Heat shock protein 83-1. |
| Subcellular Location | Cytoplasm[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q4I0|Q4Q4I0_LEIMA Heat shock protein 83-1 - Leishmania major TETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRL CIRVVPDKENKTLTVEDNGIGMTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGV GFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPESDMKRGTRITLHLKEDQME YLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDEEDTKKADEDGEEPKVEEVKEG DEGKKKKTKKVKEVTKEYEVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHF SVEGQLEFRSIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVV DSEDLPLNISRENLQQNKILKVIRKNIVKKCLEMFDEVAENKEDYKQFYEQFGKNIKLGI HEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITGDSKKKLETSPFIE QARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACE KLCKTMKEVLGDKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMM SKKTMELNPRHPIIKELRRRVGADENDKAVKDLVFLLFDTSLLTSGFQLEDPTGYAERIN RMIKLGLSLDEEEEAAEAPVAETAPAEVTAGTSSMEQVD |
| DNA Sequence | >LmjF33.0318 |HSP83-4||heat shock protein 83-1|Leishmania major|chr 33|||Manual ATGACGGAGA CGTTCGCGTT CCAGGCGGAG ATCAATCAGT TGATGTCGCT GATCATCAACACCTTCTACT CGAACAAGGA GATCTTCCTG CGCGAGCTGA TCAGCAATGC GTCGGATGCGTGCGACAAGA TCCGCTACCA GAGCCTGACG GACCCGTCGG TGCTGGGCGA GTCGCCTCGCCTGTGCATCC GCGTGGTGCC GGACAAGGAG AACAAGACGC TGACGGTGGA GGATAACGGCATCGGTATGA CCAAGGCGGA CCTCGTGAAC AACCTGGGCA CGATCGCGCG CTCCGGCACGAAGGCGTTCA TGGAAGCGCT GGAGGCCGGC GGCGACATGA GCATGATCGG CCAGTTCGGTGTCGGCTTCT ACTCGGCGTA CCTTGTGGCG GACCGCGTGA CGGTGACGTC GAAGAACAACTCCGACGAGT CGTACGTATG GGAGTCGTCC GCGGGCGGCA CGTTCACGAT CACGAGCACGCCGGAGTCGG ACATGAAGCG CGGCACGCGC ATCACGCTGC ACCTCAAGGA GGACCAGATGGAGTACCTGG AGCCGCGCCG CCTGAAGGAG CTGATCAAGA AGCACTCCGA GTTCATCGGCTACGACATCG AGCTGATGGT GGAGAAGACG ACGGAGAAGG AGGTGACGGA CGAGGACGAGGAGGATACGA AGAAGGCCGA CGAGGACGGG GAGGAGCCGA AGGTGGAGGA GGTGAAGGAGGGCGACGAGG GCAAGAAGAA GAAGACGAAG AAGGTGAAGG AGGTGACGAA GGAGTACGAGGTTCAGAACA AGCACAAGCC GCTCTGGACG CGCGACCCGA AGGACGTGAC GAAGGAAGAGTACGCGGCCT TCTACAAGGC CATCTCCAAC GACTGGGAGG ACCCGGCGGC GACGAAGCACTTCTCTGTGG AGGGCCAGCT GGAGTTCCGC TCGATCATGT TCGTGCCGAA GCGCGCGCCGTTCGACATGT TCGAGCCGAA CAAGAAGCGC AACAACATCA AGCTGTACGT GCGCCGCGTGTTCATCATGG ACAACTGCGA GGACCTGTGC CCGGACTGGC TCGGCTTCGT GAAGGGCGTCGTGGACAGCG AGGACCTGCC GCTGAACATC TCGCGCGAGA ACCTGCAGCA GAACAAGATCCTGAAGGTGA TCCGCAAGAA CATCGTGAAG AAGTGCCTTG AAATGTTCGA CGAGGTGGCGGAGAACAAGG AGGACTACAA GCAGTTCTAC GAGCAGTTCG GCAAGAACAT CAAGCTGGGCATCCACGAGG ACACGGCGAA CCGCAAGAAG CTGATGGAGT TGCTGCGCTT CTACAGCACCGAGTCGGGCG AGGAGATGAC GACGCTGAAG GACTACGTGA CGCGCATGAA GGCGGGGCAGAAGTCGATCT ACTACATCAC CGGCGACAGC AAGAAGAAGC TGGAGACGTC GCCGTTCATTGAGCAGGCGA GGCGCCGCGG GCTCGAGGTG CTGTTCATGA CGGAGCCGAT CGACGAGTACGTGATGCAGC AGGTGAAGGA CTTCGAGGAC AAGAAGTTCG CGTGCCTGAC GAAGGAGGGCGTGCACTTCG AGGAGTCGGA GGAGGAGAAG CAGCAGCGCG AGGAGGAGAA GGCGGCGTGCGAGAAGCTGT GCAAGACGAT GAAGGAGGTG CTGGGCGACA AGGTGGAGAA GGTGATCGTGTCGGAGCGCC TGTCGACGTC GCCGTGCATC CTGGTGACGT CGGAGTTCGG GTGGTCGGCGCACATGGAGC AGATCATGCG CAACCAGGCG CTGCGCGACT CCAGTATGGC GCAGTACATGATGTCCAAGA AGACGATGGA GCTCAACCCC AGACACCCCA TCATCAAGGA GCTGCGCCGCCGCGTGGGCG CGGACGAGAA CGACAAGGCC GTGAAGGACC TCGTCTTCCT GCTCTTCGACACGTCGCTGC TCACGTCCGG CTTCCAGCTG GAGGACCCCA CCGGCTACGC CGAGCGCATCAACCGCATGA TCAAGCTCGG TCTGTCGCTC GACGAGGAGG AGGAGGCAGC CGAGGCGCCGGTGGCCGAGA CGGCCCCCGC GGAGGTCACC GCCGGCACCT CCAGCATGGA GCAGGTGGACTGA |
| Heat shock protein 83-1 Q4Q4I0] | |
|---|---|
| Metabolite Information | protein folding; protein refolding; response to unfolded protein |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K04079 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | tumor rejection antigen (gp96) 1 [Homo sapiens] | 45 | 1e-164 | 574 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| topA DNA topoisomerase I | Mycoplasma genitalium | 47% | 0.005 | 37.4 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 36-39; 71-74; 139-142; 369-372; | PS00722 | |
| PDOC00270 | Heat shock hsp90 proteins family signature | 23-32; | PS00298 | |
| PDOC00015 | The rule PS00015 has been deleted from the PROSITE database and replaced by the following motif: PS50079 (Bipartite nuclear localization signal profile | 471-487; 472-488 | PS00015 | |
| Acylation | N-myristoylation site | 80-85; 82-87; 110-115; 152-157; 168-173; 359-364; 623-628; | PS00008 | |
| Amidation | Amidation site | 243-246; | PS00009 | |
| Glycosylation | N-glycosylation site | 36-39; 71-74; 139-142; 369-372; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 166-169; 193-196; 246-249; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 24-27; 48-51; 75-78; 84-87; 159-162; 211-214; 216-219; 277-280; 442-445; 448-451; 526-529; 546-549; 669-672; 694-697; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 24-26; 58-60; 136-138; 211-213; 223-225; 249-251; 448-450; 470-472; 546-548; 561-563; 602-604; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 138-145; 193-201; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 138-152; 649-663; | PS00003 | |
| Heat shock protein 83-1 [Q4Q4I0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2cg9B | |
| Percent Identity | 60% | |
| Target Region | 1-671 | |
| Template Region | 2-618 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 84412-18-0 | ADENOSINE-5'-TRIPHOSPHATE | 507.181 | C10 H16 N5 O13 P3 | O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 2cg9 |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/559740/Q4Q4I0.pdb 2.0 669 = residues | | = | *| Ramachandran plot: 84.2% core 12.5% allow 2.1% gener 1.1% = disall | | = | *| All Ramachandrans: 42 labelled residues (out of 667) = | +| Chi1-chi2 plots: 4 labelled residues (out of 452) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 7.7 Bad contacts: = 23 | *| Bond len/angle: 11.3 Morris et al class: 1 = 1 3 | +| 2 cis-peptides = | | G-factors Dihedrals: -0.14 Covalent: -0.21 Overall: = -0.16 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | *| M/c bond angles: 92.8% within limits 7.2% highlighted 3 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |