| Guanylate kinase, putative [Q4Q481] | |
|---|---|
| Systematic Name | LmjF.33.1090 [Leishmania major] |
| Gene Name | LMJF_33_1090 |
| Molecular Weight | 22931 Da |
| Protein Sequence Size | 203 |
| Function | |
| Charge | -0.5 |
| Isoelectric Point | 6.3 pH |
| Description | Guanylate kinase, putative (EC 2.7.4.8). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.4.8 |
| Sequence | >tr|Q4Q481|Q4Q481_LEIMA Guanylate kinase, putative (EC 2.7.4.8) - Leishmania major. SKPLNALVVCGPSGVGKGTLLGRLLREYPNRFAYSVSHTTRQPRQGEVNGREYHFTDRES ILKMRDNNEFLELCDVHGNFYGTSVAAVHAVQKEGKVCVIEIDVKGAQKLFSRTDNALNA VYFFITAPREELRKRIMKRGADDETMLQRRLETAESEYKFVDENPDFFSVLLVNDELEAA YAGLLAAIDDQLVKHNMEKLAA |
| DNA Sequence | >LmjF33.1090 |||guanylate kinase, putative|Leishmania major|chr 33|||Manual ATGAGCAAGC CGTTGAACGC GCTGGTGGTC TGTGGTCCCT CTGGGGTAGG CAAGGGAACCCTGCTGGGCC GCCTCCTCCG CGAGTACCCC AACCGCTTCG CCTACTCGGT GTCGCACACAACACGTCAAC CGCGCCAGGG AGAGGTGAAT GGGCGCGAGT ACCACTTTAC CGACCGTGAGAGCATCCTCA AGATGCGCGA CAATAACGAG TTCCTCGAGC TGTGCGACGT GCACGGCAACTTCTACGGCA CGAGCGTTGC CGCCGTGCAC GCTGTGCAGA AGGAAGGGAA GGTGTGCGTCATCGAGATCG ATGTAAAGGG GGCACAGAAA CTGTTCAGCC GTACCGATAA TGCGCTGAACGCCGTGTACT TCTTTATCAC GGCCCCCAGA GAGGAGCTGC GCAAGCGTAT CATGAAGCGTGGCGCCGATG ACGAAACAAT GCTGCAGCGG CGTCTAGAGA CAGCCGAGTC AGAGTACAAGTTCGTCGATG AAAATCCCGA CTTCTTCTCT GTGCTGCTGG TGAATGATGA GCTAGAGGCAGCGTACGCTG GCCTCTTGGC CGCCATCGAC GACCAGCTGG TGAAGCACAA CATGGAGAAGCTGGCTGCCT AG |
| Guanylate kinase, putative Q4Q481] | |
|---|---|
| Metabolite Information | nucleobase, nucleoside and nucleotide interconversion |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K00942 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | guanylate kinase 1 [Homo sapiens] | 36 | 4e-30 | 128 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YDR454c guanylate kinase | Saccharomyces cerevisiae | 41% | 3e-35 | 142 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00670 | Guanylate kinase-like signature and profile | 40-57; | PS00856 | |
| PDOC00670 | Guanylate kinase-like signature and profile | 35.518 | 5-190 | PS50052 |
| Acylation | N-myristoylation site | 15-20; 19-24; 79-84; 83-88; 184-189; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 57-60; 113-116; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 40-42; 57-59; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 152-166; | PS00003 | |
| Guanylate kinase, putative [Q4Q481] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1gkyA | |
| Percent Identity | 41% | |
| Target Region | 5-193 | |
| Template Region | 1-186 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 85-32-5 | GUANOSINE-5'-MONOPHOSPHATE | 363.221 | C10 H14 N5 O8 P | O=C1c2ncn(c2N=C(N)N1)C3OC(C(O)C3O)COP(=O)(O)O | 1gky |
| ACETYL GROUP | 44.053 | C2 H4 O | O=CC | 1gky | |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S | [O-]S([O-])(=O)=O | 1gky |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2455296/Q4Q481.pdb 2.0 189 = residues | | = | | Ramachandran plot: 95.9% core 4.1% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 187) = | +| Chi1-chi2 plots: 3 labelled residues (out of 119) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 5.5 Bad contacts: = 1 | +| Bond len/angle: 4.6 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.16 Covalent: -0.11 Overall: = 0.06 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 95.3% within limits 4.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |