| Mitogen activated protein kinase, putative [Q4Q449] | |
|---|---|
| Systematic Name | LmjF.33.1380 [Leishmania major] |
| Gene Name | MPK11 |
| Molecular Weight | 46877 Da |
| Protein Sequence Size | 408 |
| Function | |
| Charge | -3 |
| Isoelectric Point | 6.1 pH |
| Description | Mitogen activated protein kinase, putative (Map kinase, putative). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q449|Q4Q449_LEIMA Mitogen activated protein kinase, putative (Map kinase, putative) - Leishmania major. PATKSLAELQAEVRRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEV ILAKRILREIKLLAHFNDDNIIGLRNILTPKDPENFDHFYIVMDIMETDLKQVLRSGQEL TEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYM TDYVTMRWYRAPELVMEDKDYSVQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVI GTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPKASPEALDLLRHMLVFNPKRRITV LQAMRHPFLEQLHDDADDNLSYTLFRFDENEQKTIMDVKRAIYKESVKFHNEHPSSMRAT TMYSAFNTPSVAAPSVATEGEGRSAQQTIEKNIPEDVAEGNFDREQV |
| DNA Sequence | >LmjF33.1380 |MPK11||mitogen activated protein kinase, putative|Leishmania major|chr 33|||Manual ATGCCGGCCA CCAAGTCACT AGCGGAGCTG CAGGCGGAGG TCCGCCGCCT GGATGACCGCTACCTTCTGG AGCGCATCAT CGGCGCCGGA TCCTATGGCG TTGTGATTCG CGCGCGTGACACCAAGAGCG ACAATCGCCT TGTCGCCATG AAGCGCGTGA ACAAGGAAAT CTTTGAAGAAGTTATTCTAG CGAAGCGCAT TCTGCGCGAG ATCAAGCTGC TGGCGCACTT TAATGACGACAACATCATTG GCCTGCGCAA CATCCTCACC CCGAAGGACC CGGAGAACTT TGACCACTTCTACATCGTAA TGGATATTAT GGAAACCGAC CTAAAACAGG TGCTGCGCAG CGGGCAGGAGCTGACGGAGG CGCACATTCA GTTCTTCATC TACCAGGCAC TGCGTGCGCT GCACATTATTCACAGCGCCG GCGTCATCCA CCGTGATATT ACGCCGGCGA ACATTCTGGT AAACACGAACTGCGACTTGA AGATTTGCGA CTTCGGCCTG GCGAAGGAGG AAAACGACCA GGGCGAGTACATGACGGACT ACGTGACGAT GCGCTGGTAC CGTGCGCCGG AATTGGTGAT GGAGGACAAGGACTACTCAG TGCAGATTGA TGTGTGGGGC ATCGGCTGCA TCCTCGGCGA GCTACTCGGCTCTCGGCCGC TCTTCCAGGG GAAAGACCGG GTGAACCAAC TGGACAAGAT AGTCGATGTGATCGGTACGC CGTCTGAGGA AGACATCAAC TCCGTAGGAT CGTCTGCTGC GCAGAAGTACCTCAAGAAGA AGAGTCACCG ACCGCAAGCT GACTGGCGCC AGCGCTACCC GAAGGCGTCACCGGAGGCGC TCGACCTGCT GCGCCACATG CTGGTCTTCA ACCCGAAGCG GCGAATCACGGTGCTGCAGG CGATGCGTCA CCCGTTCCTG GAGCAGCTGC ACGACGACGC GGATGATAACCTCAGCTACA CTCTCTTCCG CTTTGACGAG AACGAGCAGA AGACGATAAT GGATGTGAAGCGCGCCATCT ACAAGGAGAG TGTCAAGTTT CACAATGAGC ATCCATCCTC GATGCGGGCAACGACCATGT ACAGCGCCTT CAACACCCCC AGTGTAGCCG CACCGAGCGT GGCTACAGAGGGCGAGGGCC GCTCGGCGCA GCAGACGATT GAGAAGAACA TTCCCGAGGA CGTGGCAGAGGGCAATTTTG ACCGTGAGCA GGTCTGA |
| Mitogen activated protein kinase, putative Q4Q449] | |
|---|---|
| Metabolite Information | protein amino acid phosphorylation |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K04371 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | mitogen-activated protein kinase 1 [Homo sapiens] | 42 | 9e-79 | 291 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YBR160w cyclin-dependent protein kinase | Saccharomyces cerevisiae | 33% | 2e-40 | 160 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00100 | Protein kinases signatures and profile | 27-51; | PS00107 | |
| PDOC00100 | Protein kinases signatures and profile | 145-157; | PS00109 | |
| PDOC00100 | Protein kinases signatures and profile | 45.262 | 21-310 | PS50011 |
| Acylation | N-myristoylation site | 118-123; 212-217; 253-258; | PS00008 | |
| Glycosylation | N-glycosylation site | 320-323; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 262-265; 297-300; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 6-9; 41-44; 90-93; 117-120; 159-162; 243-246; 245-248; 335-338; 379-382; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 90-92; 186-188; 265-267; 347-349; 357-359; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 15-21; 172-180; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 173-187; 195-209; | PS00003 | |
| Mitogen activated protein kinase, putative [Q4Q449] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 4erkA | |
| Percent Identity | 42% | |
| Target Region | 5-357 | |
| Template Region | 7-350 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 145 | Sidechain |
| THR | 147 | Sidechain (LYS 149 In Template) |
| ASN | 150 | Sidechain |
| MET | 183 | Sidechain (THR 188 In Template) |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 101622-51-9 | OLOMOUCINE | 298.343 | C15 H18 N6 O | n2c1c(ncn1C)c(nc2NCCO)NCc3ccccc3 | 4erk |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S | [O-]S([O-])(=O)=O | 4erk |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/104648/Q4Q449.pdb 2.0 350 = residues | | = | *| Ramachandran plot: 87.0% core 10.2% allow 2.2% gener 0.6% = disall | | = | *| All Ramachandrans: 13 labelled residues (out of 348) = | | Chi1-chi2 plots: 0 labelled residues (out of 250) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 7 | *| Bond len/angle: 8.3 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.64 Covalent: -0.18 Overall: = 0.34 | | = | *| M/c bond lengths: 99.1% within limits 0.9% highlighted 1 off = graph | *| M/c bond angles: 93.3% within limits 6.7% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |