| Ribulose-5-phosphate 3-epimerase, putative [Q4Q431] | |
|---|---|
| Systematic Name | LmjF.33.1570 [Leishmania major] |
| Gene Name | LMJF_33_1570 |
| Molecular Weight | 28064 Da |
| Protein Sequence Size | 262 |
| Function | |
| Charge | -1.5 |
| Isoelectric Point | 6.2 pH |
| Description | Ribulose-5-phosphate 3-epimerase, putative (EC 5.1.3.1). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 5.1.3.1 |
| Sequence | >tr|Q4Q431|Q4Q431_LEIMA Ribulose-5-phosphate 3-epimerase, putative (EC 5.1.3.1) - Leishmania major. TEFNRYNHEDKSTWLNAVEKPQAPLEAIIDPSILAADFCKLGDEVASVVSPAGGAVEWIH VDVMDGHMVPNISIGPGVVSSLRARFPNVFLDVHCMVSDPKQWVPSIAKAGGSGYTFHIE ATNDSKGVAEHIRAHGMQVGVAVKPATNLTQELRDLIEGHYVDQVLVMTVEPGFGGQSFI QERLSFISELRRNYPHLNIGVDGGIGPSTAVQAADAGANILIAGTSVFRAGDRKAAIEEL RASAKSGICKNSIQRALPGMR |
| DNA Sequence | >LmjF33.1570 |||ribulose-5-phosphate 3-epimerase, putative|Leishmania major|chr 33|||Manual ATGACGGAGT TCAACCGTTA CAACCACGAG GACAAGTCGA CGTGGCTGAA CGCCGTCGAGAAACCGCAGG CGCCGCTGGA AGCCATCATC GACCCGTCCA TTCTCGCGGC AGACTTCTGCAAGCTCGGCG ACGAGGTGGC GAGCGTCGTA TCACCGGCGG GGGGCGCAGT GGAATGGATTCACGTTGACG TGATGGATGG GCACATGGTG CCGAACATTA GCATCGGCCC CGGCGTCGTCTCCTCTCTGC GCGCGCGCTT TCCGAATGTG TTTCTTGACG TTCACTGCAT GGTGAGTGACCCTAAACAGT GGGTCCCTTC CATAGCCAAG GCGGGCGGCT CCGGCTACAC CTTCCACATTGAAGCAACCA ATGACAGCAA GGGCGTTGCG GAGCACATTC GCGCTCATGG AATGCAGGTCGGCGTGGCGG TGAAGCCGGC AACAAATCTC ACCCAAGAGC TGAGGGATCT AATTGAAGGCCACTACGTGG ATCAGGTGCT GGTCATGACT GTGGAGCCTG GATTCGGTGG CCAGTCTTTTATCCAGGAAC GGCTTAGCTT CATCTCCGAG CTGCGTCGCA ACTACCCACA CCTAAACATTGGTGTTGATG GTGGCATTGG CCCCAGCACG GCGGTGCAGG CGGCCGACGC CGGCGCCAACATCCTGATTG CCGGTACGTC GGTGTTCAGG GCCGGCGACC GCAAGGCGGC TATCGAGGAGCTGCGCGCCT CGGCGAAGAG TGGCATCTGC AAGAACTCGA TTCAAAGGGC ACTACCAGGGATGAGGTAA |
| Ribulose-5-phosphate 3-epimerase, putative Q4Q431] | |
|---|---|
| Metabolite Information | de novo' pyrimidine base biosynthesis; carbohydrate metabolism; pentose-phosphate shunt |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01783 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | ribulose-5-phosphate-3-epimerase isoform 1 [Homo sapiens] | 42 | 6e-46 | 181 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| rpe Pentose-5-phosphate-3-epimerase | Streptococcus pneumoniae | 41% | 1e-35 | 144 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 72-75; 124-127; 149-152; | PS00722 | |
| Acylation | N-myristoylation site | 78-83; 113-118; 137-142; 201-206; 205-210; 248-253; | PS00008 | |
| Glycosylation | N-glycosylation site | 72-75; 124-127; 149-152; | PS00001 | |
| Phosphorylation | Protein kinase C phosphorylation site | 82-84; 244-246; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 155-162; | PS00007 | |
| Ribulose-5-phosphate 3-epimerase, putative [Q4Q431] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1h1zB | |
| Percent Identity | 44% | |
| Target Region | 27-246 | |
| Template Region | 5-217 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| HIS | 35 | Sidechain |
| ASP | 37 | Sidechain |
| HIS | 69 | Sidechain |
| ASP | 177 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S | [O-]S([O-])(=O)=O | 1h1z |
| 23713-49-7 | ZINC ION | 65.409 | Zn | [Zn+2] | 1h1z |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2570212/Q4Q431.pdb 2.0 220 = residues | | = | *| Ramachandran plot: 93.5% core 5.4% allow 0.5% gener 0.5% = disall | | = | +| All Ramachandrans: 6 labelled residues (out of 218) = | +| Chi1-chi2 plots: 2 labelled residues (out of 112) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 4.0 Bad contacts: = 4 | +| Bond len/angle: 4.9 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: -0.02 Covalent: -0.15 Overall: = -0.07 | | = | | M/c bond lengths: 98.7% within limits 1.3% highlighted = | | M/c bond angles: 93.9% within limits 6.1% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |