| Udp-glc 4'-epimerase, putative [Q4Q3V7] | |
|---|---|
| Systematic Name | LmjF.33.2300 [Leishmania major] |
| Gene Name | LMJF_33_2300 |
| Molecular Weight | 43615 Da |
| Protein Sequence Size | 391 |
| Function | |
| Charge | 0 |
| Isoelectric Point | 6.5077 pH |
| Description | Udp-glc 4'-epimerase, putative (EC 5.1.3.2). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 5.1.3.2 |
| Sequence | >tr|Q4Q3V7|Q4Q3V7_LEIMA Udp-glc 4'-epimerase, putative (EC 5.1.3.2) - Leishmania major. RVLVCGGVGYIGTHFVRELLRYSPHDVIIADSLEATHGSDVHVDTEKNYAARNPGANLEE VKRSGYRFAKLEVGDVRDVDFLEHVFTTHAPIDAVVHMCAHIVVPESVRDPLRYYDNNVV GMLRILQIMLKYKCDKLILSSTAALFGNPYARMRAGSTDEPDPMKPIRSNAKCMPESPYG TTKLVGEYMLKDCAAAYGIKSVCLRYFNACGADAEGDIGETHEPESHLIPLILRVPLADK INAYNAVHHPERQKVNGYVSIFGTDYPTPDGTCIRDYVHVKDLSSAHVRALDYLAKLTPD DKDRFFSTFNLGTSKGYSVREVIEAARRVTGHPIPEREEKRRDGDPPVLVASGEEAAAAL GWTLEYESIDKIIESAWKFHSKHPVGYELH |
| DNA Sequence | >LmjF33.2300 |||udp-glc 4'-epimerase, putative|Leishmania major|chr 33|||Manual ATGAGGGTAC TTGTCTGTGG TGGTGTGGGG TATATTGGCA CGCACTTTGT GCGCGAGCTACTGCGTTACA GCCCCCATGA TGTGATCATT GCCGACAGCC TCGAGGCCAC TCACGGTTCTGATGTGCACG TGGACACGGA GAAAAACTAT GCTGCACGCA ACCCTGGCGC AAACTTAGAAGAGGTGAAGA GGAGCGGCTA CCGTTTCGCA AAGCTGGAGG TGGGCGACGT GCGTGATGTCGACTTTCTCG AGCACGTTTT CACCACGCAC GCCCCGATCG ATGCCGTGGT GCACATGTGTGCGCACATTG TGGTGCCGGA GAGTGTGCGC GACCCGCTTC GGTACTACGA CAACAACGTCGTTGGTATGC TGCGCATTTT GCAGATCATG CTCAAGTACA AGTGCGACAA GCTCATTCTCTCCAGTACGG CCGCTCTCTT CGGTAACCCT TACGCTCGCA TGAGGGCTGG CTCGACCGATGAGCCGGACC CGATGAAGCC TATCCGGTCC AACGCCAAGT GCATGCCGGA GAGTCCGTATGGCACGACCA AGCTGGTGGG CGAGTACATG CTGAAGGACT GCGCTGCCGC CTACGGCATCAAAAGCGTGT GTCTGCGCTA CTTCAATGCA TGCGGCGCCG ACGCCGAGGG CGACATTGGCGAGACCCACG AGCCCGAGTC GCATCTTATC CCGCTCATCC TGCGCGTGCC GCTGGCGGACAAGATAAACG CTTACAACGC TGTGCACCAT CCGGAGCGCC AAAAGGTGAA CGGCTACGTTTCCATCTTCG GCACCGACTA CCCAACTCCG GACGGCACGT GCATTCGGGA TTACGTGCACGTGAAGGATC TGTCCTCGGC TCACGTTCGG GCGCTGGACT ACCTGGCTAA GCTGACCCCCGACGACAAGG ACAGGTTCTT TTCCACGTTC AACCTTGGCA CGTCGAAGGG TTACTCAGTGCGCGAGGTCA TCGAGGCGGC GCGGCGCGTA ACGGGACACC CGATTCCAGA AAGGGAGGAGAAGCGCCGCG ACGGCGACCC CCCGGTGCTC GTGGCGTCCG GTGAGGAGGC GGCGGCAGCACTTGGGTGGA CTCTGGAGTA CGAATCGATC GACAAGATTA TCGAATCCGC GTGGAAGTTTCACAGTAAGC ACCCTGTCGG CTACGAGCTC CACTAA |
| Udp-glc 4'-epimerase, putative Q4Q3V7] | |
|---|---|
| Metabolite Information | biosynthesis; galactose metabolism; nucleotide-sugar metabolism; steroid biosynthesis |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01784 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | UDP-galactose-4-epimerase [Homo sapiens] | 32 | 1e-43 | 174 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| galE UDP-glucose 4-epimerase | Streptococcus pneumoniae | 35% | 8e-53 | 201 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00015 | The rule PS00015 has been deleted from the PROSITE database and replaced by the following motif: PS50079 (Bipartite nuclear localization signal profile | 328-344; | PS00015 | |
| Acylation | N-myristoylation site | 148-153; 313-318; | PS00008 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 328-331; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 24-27; 108-111; 158-161; 299-302; 319-322; 353-356; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 46-48; 108-110; 182-184; 314-316; 319-321; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 173-180; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 360-374; | PS00003 | |
| Udp-glc 4'-epimerase, putative [Q4Q3V7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2cnbD | |
| Percent Identity | 58% | |
| Target Region | 1-391 | |
| Template Region | 1-364 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASN | 119 | Sidechain |
| THR | 143 | Sidechain (SER 142 In Template) |
| TYR | 180 | Sidechain |
| LYS | 184 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 663.425 | C21 H27 N7 O14 P2 | c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N | 2cnb | |
| 58-98-0 | URIDINE-5'-DIPHOSPHATE-4-DEOXY-4-FLUORO-ALPHA- D-GALACTOSE | 568.293 | C15 H23 F N2 O16 P2 | O=P(OC1OC(C(F)C(O)C1O)CO)(O)OP(=O)(O)OCC3OC(N2C=CC(=O)NC2=O)C(O)C3O | 2cnb |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1436535/Q4Q3V7.pdb 2.0 391 = residues | | = | +| Ramachandran plot: 93.2% core 6.5% allow 0.3% gener 0.0% = disall | | = | +| All Ramachandrans: 7 labelled residues (out of 389) = | +| Chi1-chi2 plots: 3 labelled residues (out of 225) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.3 Bad contacts: = 1 | *| Bond len/angle: 7.2 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.61 Covalent: -0.24 Overall: = 0.29 | | = | | M/c bond lengths: 99.0% within limits 1.0% highlighted = | | M/c bond angles: 93.4% within limits 6.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |