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Succinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial, putative [Q4Q3V3]
Systematic NameLmjF.33.2340 [Leishmania major]
Gene NameLMJF_33_2340
Molecular Weight52551 Da
Protein Sequence Size489
Function
Charge6.5
Isoelectric Point7.8753 pH
DescriptionSuccinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial, putative (EC 2.8.3.5).
Subcellular LocationMitochondrion[Predict]
E. C. Number 2.8.3.5
Sequence>tr|Q4Q3V3|Q4Q3V3_LEIMA Succinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial, putative (EC 2.8.3.5) - Leishmania major.
LRRNFWRLVGLDKVQSLEEAVADMTDGISVAVGGFGCSGVPDAVISAMCKKGPKDMILYT
DSAGIDGFGLARLIETKQVRRICCSFVGMNKIFKRRYLEGDVELEFVPQGTLAERMRAGG
AGIPAFYTATAYGTQRQTGGQIIRYDKNGVPCVISAPKETRQFGNRWYVLEETIRPDYAI
VKALKADKSGNLVFRGTARNFNIPAAQCGRRVIAEVEQVVENGEIHPDDVHLPGVYVHRV
VQASYEVPIEKRTVSGSGAEPSSVNPNDDRQKIARRAALEFTDGVYANLGIGIPTEAANY
MPAGVTVTLHSENGLLGMGPFPTADKVSADWINAGKQTISFLPGAACFDSATSFAMIRGG
HMNLTMLGALEVSSNGDLANWGIPGKLVNGPGGAMDLVASGSRVVVTMSHCNKRGDSKLV
ERCSLPVTGLHCVTRIITEKAVFDVIDKHLVLKEVAEGLTVDDIKKCTAAHFEVDKVKPI
AYAAPISG
DNA Sequence>LmjF33.2340 |||succinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial precursor, putative|Leishmania major|chr 33|||Manual
ATGCTTCGCC GTAACTTCTG GCGCCTTGTC GGCCTCGACA AGGTACAGTC CTTGGAGGAGGCCGTCGCGG ACATGACGGA TGGAATCTCT GTGGCGGTCG GCGGATTTGG CTGCAGTGGTGTGCCGGACG CTGTCATCAG CGCCATGTGC AAAAAGGGTC CAAAGGACAT GATTCTCTACACGGACTCGG CGGGTATCGA CGGCTTCGGT CTCGCTCGTC TCATCGAGAC GAAGCAGGTGCGCCGCATAT GCTGTTCTTT TGTGGGTATG AACAAGATCT TCAAGAGGCG CTACCTCGAGGGCGACGTTG AGCTCGAGTT TGTGCCGCAA GGAACACTGG CGGAACGCAT GCGTGCTGGCGGCGCGGGCA TCCCTGCCTT CTACACGGCG ACGGCGTATG GCACGCAGCG TCAGACAGGAGGGCAAATTA TCCGGTACGA CAAGAACGGC GTGCCGTGTG TCATCTCGGC GCCGAAGGAGACGCGGCAGT TCGGGAATCG GTGGTACGTT CTGGAGGAGA CGATCCGACC GGATTACGCGATTGTGAAGG CGCTGAAGGC GGACAAGAGC GGCAACCTTG TGTTCCGCGG GACTGCCCGCAACTTTAACA TCCCCGCTGC GCAGTGTGGG CGGCGCGTGA TTGCAGAAGT GGAGCAGGTGGTAGAGAACG GCGAAATCCA CCCGGACGAC GTGCACTTGC CTGGCGTGTA CGTGCACCGCGTTGTGCAAG CGTCGTACGA GGTGCCCATC GAGAAGCGAA CGGTGTCCGG TAGCGGCGCAGAGCCGAGCA GCGTGAACCC AAACGACGAC CGCCAGAAGA TCGCGCGGCG AGCGGCGCTGGAGTTTACAG ACGGCGTGTA CGCGAACCTC GGCATCGGCA TCCCCACGGA GGCGGCGAACTATATGCCCG CCGGCGTGAC GGTGACACTG CATTCTGAGA ACGGGCTGCT GGGCATGGGCCCGTTCCCGA CAGCGGACAA GGTGAGCGCT GACTGGATCA ACGCCGGAAA GCAGACGATCTCGTTCCTGC CGGGAGCAGC GTGCTTCGAC AGCGCGACGT CGTTCGCGAT GATTCGCGGCGGCCACATGA ACCTGACGAT GCTGGGTGCG CTTGAGGTTT CGTCGAACGG CGACCTCGCGAACTGGGGTA TCCCCGGCAA GCTCGTCAAC GGCCCTGGTG GTGCGATGGA CCTCGTCGCGAGCGGCTCTC GCGTGGTGGT GACGATGTCG CACTGCAACA AGAGAGGCGA CTCGAAGCTTGTGGAGAGGT GCTCGCTGCC TGTGACGGGC CTGCATTGCG TGACCCGCAT CATCACGGAAAAAGCCGTAT TTGATGTGAT CGACAAACAT CTCGTTCTGA AGGAGGTCGC AGAGGGCCTGACAGTAGACG ACATCAAGAA GTGCACTGCT GCTCACTTTG AAGTGGACAA GGTAAAACCGATAGCGTACG CAGCCCCCAT ATCCGGCTGA
Succinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial, putative Q4Q3V3]
Metabolite Informationmetabolism
Molecular Function
Biochemical Pathway
Regulatory Pathway
KEGG PathwaysK01028
Orthologs
Homologs GI Percent Identity Evalue Score
Homo sapiens3-oxoacid CoA transferase 1 precursor [Homo sapiens]521e-139493
DEG Information
DEG Protein DEG Organism Percent Identity Evalue Bit Score
atoA acetate CoA-transferase beta subunitHaemophilus influenzae47%6e-50192
Post Translational Modification
PTM Type PTM Sub Type Score Modification Site Prosite ID
PDOC00016Cell attachment sequence415-417; PS00016
PDOC00980Coenzyme A transferases signatures27-42; PS01273
PDOC00980Coenzyme A transferases signatures310-318; PS01274
PDOC00595Formate--tetrahydrofolate ligase signatures364-367; PS00722
PDOC00015The rule PS00015 has been deleted from the PROSITE database and replaced by the following motif: PS50079 (Bipartite nuclear localization signal profile81-97; PS00015
AcylationN-myristoylation site28-33; 34-39; 40-45; 197-202; 259-264; 285-290; 305-310; 360-365; PS00008
AmidationAmidation site209-212; PS00009
GlycosylationN-glycosylation site364-367; PS00001
PhosphorylationcAMP- and cGMP-dependent protein kinase phosphorylation site466-469; PS00004
PhosphorylationCasein kinase II phosphorylation site17-20; 112-115; 258-261; 375-378; 461-464; PS00006
PhosphorylationProtein kinase C phosphorylation site135-137; 174-176; 198-200; 439-441; PS00005
PhosphorylationTyrosine kinase phosphorylation site52-60; PS00007
Succinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial, putative [Q4Q3V3]
Model Information
Template PDB ID2nrbD
Percent Identity54%
Target Region1-489
Template Region1-469
Domain Information
Domains Start End
Active Site Information
Residue Active Site Number Functional Part
Co-Factor
Metal Description
Ligands
CAS number Name Mol. Weight Mol. Formula Smile Notation PDB Reference
16887-00-6CHLORIDE ION35.453Cl[Cl-]2nrb
Mutational Information
Residue Feature Description
Modeled Protein Template Structure
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1194022/Q4Q3V3.pdb 2.0 489 = residues | | = | *| Ramachandran plot: 92.5% core 6.8% allow 0.2% gener 0.5% = disall | | = | +| All Ramachandrans: 10 labelled residues (out of 487) = | +| Chi1-chi2 plots: 3 labelled residues (out of 256) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 5 | *| Bond len/angle: 6.7 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.03 Covalent: -0.25 Overall: = -0.08 | | = | | M/c bond lengths: 98.8% within limits 1.2% highlighted = | *| M/c bond angles: 92.0% within limits 8.0% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further.
Overlapped Structure Procheck Summary
LeishBase: Leishmania Structural Database
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