| Adenylate kinase, putative [Q4Q3J7] | |
|---|---|
| Systematic Name | LmjF.34.0110 [Leishmania major] |
| Gene Name | LMJF_34_0110 |
| Molecular Weight | 24404 Da |
| Protein Sequence Size | 218 |
| Function | |
| Charge | 1.5 |
| Isoelectric Point | 7.3 pH |
| Description | Adenylate kinase, putative (EC 2.7.4.3). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.4.3 |
| Sequence | >tr|Q4Q3J7|Q4Q3J7_LEIMA Adenylate kinase, putative (EC 2.7.4.3) - Leishmania major. KIVLMGAPGCGKGTQSPYIQDRYGLCHLSTGDMLRDAVARKTANGKLAKDAMDSGKLVSD DIVFGIVKDSIKNPECRYGYILDGYPRTLKQAQMMEDAGEKIDKVIEFSVPDEVILERTS GRWIHKSSGRTYHEVFRPPKTPGKDDITGEDLYQRPDDRREVCEKRLDIYKNETRPLADY FTKEGVYSTINANQAIDEVRKIIAALLDPIGIATGLK |
| DNA Sequence | >LmjF34.0110 |||adenylate kinase, putative|Leishmania major|chr 34|||Manual ATGAAGATTG TGCTCATGGG CGCCCCCGGC TGCGGTAAAG GTACACAGAG CCCGTACATACAGGACCGGT ACGGTCTGTG CCATCTGTCG ACGGGCGATA TGCTGCGCGA CGCGGTGGCGCGGAAGACTG CAAACGGAAA ACTGGCGAAG GACGCCATGG ATTCGGGCAA GCTTGTCAGTGACGACATTG TTTTTGGGAT TGTGAAGGAT AGCATTAAGA ACCCTGAGTG CCGCTACGGCTACATCCTAG ACGGCTACCC GCGCACGCTG AAGCAGGCGC AAATGATGGA GGACGCCGGGGAGAAGATAG ACAAGGTAAT CGAGTTCAGC GTTCCGGACG AGGTCATCCT GGAGCGGACGAGTGGGCGGT GGATTCACAA GTCGAGCGGG CGCACGTACC ACGAGGTGTT CCGCCCTCCGAAGACGCCCG GCAAGGATGA CATAACGGGT GAGGACCTCT ACCAACGCCC CGACGATCGCCGCGAGGTGT GCGAGAAGCG CCTGGATATC TATAAGAATG AGACTCGTCC TCTCGCCGACTACTTCACCA AGGAGGGCGT GTATTCGACG ATCAACGCCA ACCAAGCGAT CGACGAAGTTCGAAAGATTA TCGCCGCTTT GTTGGACCCC ATTGGCATTG CAACGGGCCT CAAGTAG |
| Adenylate kinase, putative Q4Q3J7] | |
|---|---|
| Metabolite Information | biological process unknown; nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K00939 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | adenylate kinase 2 isoform b [Homo sapiens] | 48 | 2e-55 | 212 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| adk adenylate-kinase | Salmonella typhimurium | 49% | 8e-58 | 217 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00104 | Adenylate kinase signature | 81-92; | PS00113 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 173-176; | PS00722 | |
| Acylation | N-myristoylation site | 7-12; 10-15; 186-191; 212-217; | PS00008 | |
| Glycosylation | N-glycosylation site | 173-176; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 30-33; 110-113; 132-135; 149-152; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 55-57; 71-73; 89-91; 121-123; 129-131; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 73-79; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 147-161; | PS00003 | |
| Adenylate kinase, putative [Q4Q3J7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2ak2A | |
| Percent Identity | 48% | |
| Target Region | 1-222 | |
| Template Region | 14-220 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 13 | Sidechain |
| ARG | 123 | Sidechain |
| ARG | 156 | Sidechain |
| ASP | 158 | Sidechain |
| ASP | 159 | Sidechain |
| ARG | 167 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S   | [O-]S([O-])(=O)=O | 2ak2 |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/694256/Q4Q3J7.pdb 2.0 218 = residues | | = | +| Ramachandran plot: 97.8% core 1.1% allow 1.1% gener 0.0% = disall | | = | +| All Ramachandrans: 2 labelled residues (out of 216) = | *| Chi1-chi2 plots: 5 labelled residues (out of 138) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.9 Bad contacts: = 2 | *| Bond len/angle: 6.3 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.19 Covalent: -0.13 Overall: = 0.07 | | = | | M/c bond lengths: 99.0% within limits 1.0% highlighted = | | M/c bond angles: 94.3% within limits 5.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |