| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C8] | |
|---|---|
| Systematic Name | LmjF.34.0780 [Leishmania major] |
| Gene Name | LMJF_34_0780 |
| Molecular Weight | 34272 Da |
| Protein Sequence Size | 298 |
| Function | |
| Charge | -12 |
| Isoelectric Point | 4.512 pH |
| Description | Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.1.3.16 |
| Sequence | >tr|Q4Q3C8|Q4Q3C8_LEIMA Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16) - Leishmania major. SSVSTAPQLIERLIMVQRNRAPPQLLVREEEIRAVLTEVREIFMSQPMLLEIRPPVRVCG DTHGQYYDLLRIYEKCGFPPYSNYLFLGDYVDRGKQSVETIVLQFCYKIVYPENFFLLRG NHECASVNRMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVISEKIICMHGGLSPDLTSV ASVMDIERPCDVPDRGILCDLLWADPEDDVQGFLESDRGVSYLFGEDIVNDFLDMVDMDL IVRAHQVMERGYGFFASRQLVTVFSAPNYCGEFDNDAAVMNIDDKLQCSFLIIPAFR |
| DNA Sequence | >LmjF34.0780 |||serine/threonine-protein phosphatase PP1, putative|Leishmania major|chr 34|||Manual ATGTCCAGCG TATCCACGGC GCCTCAACTC ATTGAGCGGC TCATCATGGT TCAGCGCAATCGCGCGCCTC CACAGCTGCT TGTCCGTGAG GAAGAAATCC GCGCTGTACT CACCGAGGTGCGAGAGATCT TCATGTCGCA GCCAATGCTC CTCGAGATCC GCCCGCCTGT GCGCGTGTGCGGGGACACGC ACGGACAGTA CTACGACCTG CTGCGCATCT ACGAGAAGTG CGGCTTCCCCCCATACTCGA ACTACCTGTT CCTCGGCGAC TACGTTGACC GCGGCAAGCA GAGCGTCGAGACGATTGTCT TGCAGTTCTG CTACAAGATT GTGTACCCCG AGAACTTCTT TCTTCTGCGCGGCAACCACG AGTGCGCTAG TGTGAACCGC ATGTACGGTT TTTTCGATGA TGTGAAGCGGCGGTATAACA TCAAGCTGTT CAAGGCGTTC ACGGATGTGT TCAACACGAT GCCCGTGTGCTGCGTGATTA GCGAGAAGAT CATCTGCATG CACGGTGGCC TTAGTCCTGA CCTGACCTCTGTAGCGTCCG TTATGGACAT CGAGCGTCCG TGCGACGTGC CTGATCGCGG CATCCTGTGCGATCTGCTGT GGGCGGACCC GGAGGATGAC GTGCAGGGCT TCCTGGAGAG CGACCGCGGCGTGAGCTACC TGTTCGGCGA GGACATTGTG AACGACTTCC TGGACATGGT GGACATGGACCTGATTGTGC GCGCGCACCA GGTGATGGAG CGCGGCTACG GGTTCTTTGC GAGCCGTCAGCTTGTGACCG TGTTCTCTGC GCCGAACTAC TGCGGTGAGT TCGACAACGA CGCTGCCGTGATGAACATCG ACGACAAGCT GCAGTGCTCC TTCCTGATTA TTCCCGCGTT TCGGTGA |
| Serine/threonine-protein phosphatase PP1, putative Q4Q3C8] | |
|---|---|
| Metabolite Information | protein amino acid dephosphorylation |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 1, catalytic subunit, alpha isoform 1 [Homo sapiens] | 63 | 1e-109 | 393 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER133w serthr phosphoprotein phosphatase 1, catalytic chain | Saccharomyces cerevisiae | 62% | 1e-110 | 392 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00115 | Serine/threonine specific protein phosphatases signature | 119-124; | PS00125 | |
| Acylation | N-myristoylation site | 121-126; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 183-186; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 164-166; 217-219; | PS00005 | |
| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C8] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1fjmB | |
| Percent Identity | 63% | |
| Target Region | 1-298 | |
| Template Region | 7-289 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 93 | Sidechain |
| HIS | 123 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 60-24-2 | BETA-MERCAPTOETHANOL | 78.133 | C2 H6 O S | OCCS | 1fjm |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 1fjm |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/3707766/Q4Q3C8.pdb 2.0 298 = residues | | = | *| Ramachandran plot: 91.7% core 5.3% allow 2.3% gener 0.8% = disall | | = | *| All Ramachandrans: 9 labelled residues (out of 296) = | | Chi1-chi2 plots: 0 labelled residues (out of 190) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 3 | *| Bond len/angle: 6.0 Morris et al class: 1 = 1 2 | +| 3 cis-peptides = | | G-factors Dihedrals: 0.05 Covalent: -0.13 Overall: = -0.02 | | = | | M/c bond lengths: 99.2% within limits 0.8% highlighted = | | M/c bond angles: 93.3% within limits 6.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |