| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C6] | |
|---|---|
| Systematic Name | LmjF.34.0800 [Leishmania major] |
| Gene Name | LMJF_34_0800 |
| Molecular Weight | 34441 Da |
| Protein Sequence Size | 300 |
| Function | |
| Charge | -12 |
| Isoelectric Point | 4.5229 pH |
| Description | Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.1.3.16 |
| Sequence | >tr|Q4Q3C6|Q4Q3C6_LEIMA Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16) - Leishmania major. SESVFPLVQSIVEKMLTGGDNRFQRQILIKEEEIRAVLRAVREVFMSQPMLLEIRPPVRV CGDTHGQYYDLLRIYEKCGFPPYSNYLFLGDYVDRGKQSVETIVLQFCYKIVYPENFFLL RGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVISEKIICMHGGLSPDLT SVASVMDIERPCDVPDRGILCDLLWADPEDDVQGFLESDRGVSYLFGEDIVNDFLDMVDM DLIVRAHQVMERGYGFFASRQLVTVFSAPNYCGEFDNDAAVMNIDDKLQCSFLIIPASR |
| DNA Sequence | >LmjF34.0800 |||serine/threonine-protein phosphatase PP1, putative|Leishmania major|chr 34|||Manual ATGAGCGAAT CCGTATTTCC CCTGGTACAG AGCATCGTGG AGAAGATGCT CACCGGCGGCGACAATCGCT TCCAGCGCCA AATACTCATC AAGGAAGAGG AGATCCGCGC TGTGCTGCGCGCCGTTCGAG AGGTGTTCAT GTCGCAGCCG ATGCTCCTCG AGATCCGCCC GCCTGTGCGCGTGTGCGGGG ACACGCACGG ACAGTACTAC GACCTGCTGC GCATCTACGA GAAGTGCGGCTTCCCCCCAT ACTCGAACTA CCTGTTCCTC GGCGACTACG TTGACCGCGG CAAGCAGAGCGTCGAGACGA TTGTCTTGCA GTTCTGCTAC AAGATTGTGT ACCCCGAGAA CTTCTTTCTTCTGCGCGGCA ACCACGAGTG CGCTAGCATC AACAAGATGT ACGGTTTTTT CGATGATGTGAAGCGGCGGT ATAACATCAA GCTGTTCAAG GCGTTCACGG ATGTGTTCAA CACGATGCCCGTGTGCTGCG TGATTAGCGA GAAGATCATC TGCATGCACG GTGGCCTTAG TCCTGACCTGACCTCTGTAG CGTCCGTTAT GGACATCGAG CGTCCGTGCG ACGTGCCTGA TCGCGGCATCCTGTGCGATC TGCTGTGGGC GGACCCGGAG GATGACGTGC AGGGCTTCCT GGAGAGCGACCGCGGCGTGA GCTACCTGTT CGGCGAGGAC ATTGTGAACG ACTTCCTGGA CATGGTGGACATGGACCTGA TTGTGCGCGC GCACCAGGTG ATGGAGCGCG GCTACGGGTT CTTTGCGAGCCGTCAGCTTG TGACCGTGTT CTCTGCGCCG AACTACTGCG GTGAGTTTGA CAACGACGCTGCCGTGATGA ACATCGACGA CAAGCTGCAG TGCTCCTTCC TGATTATTCC CGCATCCCGTTAG |
| Serine/threonine-protein phosphatase PP1, putative Q4Q3C6] | |
|---|---|
| Metabolite Information | protein amino acid dephosphorylation |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 1, catalytic subunit, alpha isoform 1 [Homo sapiens] | 61 | 1e-109 | 390 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER133w serthr phosphoprotein phosphatase 1, catalytic chain | Saccharomyces cerevisiae | 60% | 1e-109 | 389 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00115 | Serine/threonine specific protein phosphatases signature | 121-126; | PS00125 | |
| Acylation | N-myristoylation site | 123-128; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 11-14; 18-21; 185-188; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 166-168; 219-221; | PS00005 | |
| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C6] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1fjmB | |
| Percent Identity | 61% | |
| Target Region | 1-300 | |
| Template Region | 7-289 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 95 | Sidechain |
| HIS | 125 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 60-24-2 | BETA-MERCAPTOETHANOL | 78.133 | C2 H6 O S | OCCS | 1fjm |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 1fjm |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/726100/Q4Q3C6.pdb 2.0 300 = residues | | = | *| Ramachandran plot: 91.0% core 6.0% allow 2.3% gener 0.8% = disall | | = | +| All Ramachandrans: 8 labelled residues (out of 298) = | +| Chi1-chi2 plots: 1 labelled residues (out of 193) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 2 | *| Bond len/angle: 8.9 Morris et al class: 1 = 1 2 | +| 3 cis-peptides = | | G-factors Dihedrals: 0.05 Covalent: -0.13 Overall: = -0.02 | | = | | M/c bond lengths: 99.3% within limits 0.7% highlighted = | *| M/c bond angles: 93.9% within limits 6.1% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |