| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C5] | |
|---|---|
| Systematic Name | LmjF.34.0810 [Leishmania major] |
| Gene Name | LMJF_34_0810 |
| Molecular Weight | 34602 Da |
| Protein Sequence Size | 301 |
| Function | |
| Charge | -9.5 |
| Isoelectric Point | 4.702 pH |
| Description | Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.1.3.16 |
| Sequence | >tr|Q4Q3C5|Q4Q3C5_LEIMA Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16) - Leishmania major. SNAAILPMVQTLIEKMLTVKGNRMQRQILIKEEEIRAVLTEVREIFMSQPMLLEIRPPVR VCGDTHGQYYDLLRIFEKCGFPPYSNYLFLGDYVDRGKHSVENIILLYCYKIVYRENFFL LRGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVISEKIICMHGGLSPDL TSVASVMDIERPCDVPDRGILCDLLWADPEDDVQGFLESDRGVSYLFGEDIVNDFLDMVD MDLIVRAHQVMERGYGFFASRQLVTVFSAPNYCGEFDNDAAVMTIDDKLQCSFLIIPASK |
| DNA Sequence | >LmjF34.0810 |||serine/threonine-protein phosphatase PP1, putative|Leishmania major|chr 34|||Manual ATGAGCAACG CAGCGATTTT ACCGATGGTG CAGACTCTCA TCGAGAAGAT GCTCACCGTGAAGGGCAACC GTATGCAGCG CCAAATACTT ATCAAGGAAG AGGAGATCCG CGCTGTACTCACCGAGGTGC GAGAGATCTT CATGTCGCAG CCAATGCTCC TCGAGATCCG CCCGCCTGTGCGCGTGTGCG GGGACACGCA CGGACAGTAC TACGACCTGC TGCGCATCTT CGAGAAGTGCGGCTTCCCCC CATACTCGAA CTACCTGTTC CTCGGCGACT ACGTTGACCG CGGCAAGCACAGCGTCGAGA ACATCATCCT TCTCTACTGC TACAAGATTG TGTACCGCGA GAACTTCTTTCTTCTGCGCG GCAACCACGA GTGCGCTAGC ATCAACAAGA TGTACGGTTT TTTCGATGATGTGAAGCGGC GGTATAACAT CAAGCTGTTC AAGGCGTTCA CGGATGTGTT CAACACGATGCCCGTGTGCT GCGTGATTAG CGAGAAGATC ATCTGCATGC ACGGTGGCCT TAGTCCTGACCTGACCTCTG TAGCGTCCGT TATGGACATC GAGCGTCCGT GCGACGTGCC TGATCGCGGCATCCTGTGCG ATCTGCTGTG GGCGGACCCG GAGGATGACG TGCAGGGCTT CCTGGAGAGCGACCGCGGCG TGAGCTACCT GTTCGGCGAG GACATTGTGA ACGACTTCCT GGACATGGTGGACATGGACC TGATTGTGCG CGCGCACCAG GTGATGGAGC GCGGCTACGG GTTCTTTGCGAGCCGTCAGC TTGTGACCGT GTTCTCTGCG CCGAACTACT GCGGTGAGTT CGACAACGACGCTGCCGTGA TGACCATCGA CGACAAGCTG CAGTGCTCCT TCCTGATTAT TCCTGCGAGCAAGTGA |
| Serine/threonine-protein phosphatase PP1, putative Q4Q3C5] | |
|---|---|
| Metabolite Information | protein amino acid dephosphorylation |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 1, catalytic subunit, alpha isoform 1 [Homo sapiens] | 62 | 1e-109 | 393 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER133w serthr phosphoprotein phosphatase 1, catalytic chain | Saccharomyces cerevisiae | 61% | 1e-111 | 394 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00115 | Serine/threonine specific protein phosphatases signature | 122-127; | PS00125 | |
| Acylation | N-myristoylation site | 124-129; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 12-15; 186-189; 285-288; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 19-21; 167-169; 220-222; | PS00005 | |
| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C5] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1fjmB | |
| Percent Identity | 62% | |
| Target Region | 1-301 | |
| Template Region | 3-789 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 96 | Sidechain |
| HIS | 126 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 60-24-2 | BETA-MERCAPTOETHANOL | 78.133 | C2 H6 O S | OCCS | 1fjm |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 1fjm |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/388066/Q4Q3C5.pdb 2.0 301 = residues | | = | *| Ramachandran plot: 92.2% core 5.2% allow 1.9% gener 0.7% = disall | | = | +| All Ramachandrans: 7 labelled residues (out of 299) = | +| Chi1-chi2 plots: 2 labelled residues (out of 198) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 4 | *| Bond len/angle: 9.1 Morris et al class: 1 = 1 2 | *| 4 cis-peptides = | | G-factors Dihedrals: 0.05 Covalent: -0.17 Overall: = -0.03 | | = | | M/c bond lengths: 99.7% within limits 0.3% highlighted = | *| M/c bond angles: 93.0% within limits 7.0% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |