| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C0] | |
|---|---|
| Systematic Name | LmjF.34.0850 [Leishmania major] |
| Gene Name | LMJF_34_0850 |
| Molecular Weight | 33623 Da |
| Protein Sequence Size | 296 |
| Function | |
| Charge | -5 |
| Isoelectric Point | 5.2281 pH |
| Description | Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.1.3.16 |
| Sequence | >tr|Q4Q3C0|Q4Q3C0_LEIMA Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16) - Leishmania major. TPEDASIYTLVTSILAEWRSGVTLLKEDIIRLILRRVRPILMSQPMLVRTEAPINVCGDI HGQITDLVEIFKAGGLPPHSRYLFLGDYVDRGKYGTEVITVLLGLKVLYPKRIYVLRGNH ETDSICRIYGFFDEVKRRFNVRLFKEFTDVFNCLPVAALVEEIALCMHGGLSPELRHLRQ IEQIYRPLVVPDEGLACDLLWSDPEEGSSGWQPSERGVSFTFGEDVVKRMCDSLGIDIVL RAHQVVDEGYSFFAGRRLVTIFSASNYCGEFTNSGAMMLMDENCMCSFQIFKPEY |
| DNA Sequence | >LmjF34.0850 |||serine/threonine-protein phosphatase PP1, putative|Leishmania major|chr 34|||Manual ATGACCCCCG AGGATGCCTC CATCTACACA CTAGTCACCA GCATCCTGGC AGAGTGGCGCAGTGGCGTCA CTCTACTGAA GGAGGATATC ATTCGCTTAA TCCTGCGTCG TGTGCGCCCCATCCTCATGA GCCAGCCGAT GCTCGTCCGC ACCGAGGCGC CGATCAACGT GTGCGGCGACATACACGGCC AAATCACAGA CCTCGTCGAA ATTTTCAAGG CGGGCGGACT GCCTCCCCACTCGCGCTACC TCTTCCTCGG TGACTACGTG GACCGCGGCA AGTATGGGAC GGAAGTGATCACGGTGCTGC TGGGGTTGAA GGTGCTGTAC CCAAAGCGCA TATATGTTCT GCGCGGAAACCACGAGACGG ACAGCATTTG CCGCATCTAC GGCTTCTTTG ATGAGGTGAA GCGCCGCTTCAACGTGCGCC TGTTCAAGGA GTTCACGGAT GTGTTCAACT GCCTTCCCGT GGCGGCGTTAGTCGAGGAGA TCGCGCTCTG CATGCACGGC GGTCTCAGCC CCGAATTGCG CCACCTGCGTCAAATCGAAC AGATCTACCG GCCGCTGGTG GTGCCCGATG AGGGGCTTGC CTGCGACCTTCTCTGGTCCG ATCCGGAGGA GGGGTCGTCT GGGTGGCAAC CAAGCGAGCG CGGTGTTAGCTTTACATTCG GCGAGGATGT AGTGAAGCGC ATGTGCGACA GCCTCGGCAT CGACATCGTTCTCCGAGCCC ATCAGGTGGT GGATGAGGGC TACTCTTTCT TTGCTGGCAG GCGCCTCGTCACCATCTTTA GCGCGTCCAA CTACTGCGGC GAGTTCACCA ACAGCGGTGC CATGATGCTGATGGACGAAA ACTGCATGTG CAGCTTCCAA ATCTTTAAGC CTGAGTACTA A |
| Serine/threonine-protein phosphatase PP1, putative Q4Q3C0] | |
|---|---|
| Metabolite Information | protein amino acid dephosphorylation |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 1, catalytic subunit, beta isoform 1 [Homo sapiens] | 60 | 3e-93 | 338 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER133w serthr phosphoprotein phosphatase 1, catalytic chain | Saccharomyces cerevisiae | 59% | 4e-93 | 335 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00115 | Serine/threonine specific protein phosphatases signature | 117-122; | PS00125 | |
| Acylation | N-myristoylation site | 119-124; 218-223; | PS00008 | |
| Amidation | Amidation site | 255-258; | PS00009 | |
| Phosphorylation | Casein kinase II phosphorylation site | 2-5; 203-206; 222-225; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 215-217; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 180-186; | PS00007 | |
| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1s70A | |
| Percent Identity | 60% | |
| Target Region | 1-296 | |
| Template Region | 1-309 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 91 | Sidechain |
| ARG | 92 | Sidechain |
| ASN | 120 | Sidechain |
| HIS | 121 | Sidechain |
| ARG | 217 | Sidechain |
| HIS | 244 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 1s70 |
| 676-18-6 | TRIETHYLENE GLYCOL | 150.173 | C6 H14 O4 | OCCOCCOCCO | 1s70 |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/769014/Q4Q3C0.pdb 2.0 296 = residues | | = | *| Ramachandran plot: 89.1% core 8.9% allow 1.2% gener 0.8% = disall | | = | *| All Ramachandrans: 11 labelled residues (out of 294) = | +| Chi1-chi2 plots: 3 labelled residues (out of 182) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 3 | *| Bond len/angle: 5.3 Morris et al class: 1 = 1 2 | +| 3 cis-peptides = | | G-factors Dihedrals: 0.02 Covalent: -0.10 Overall: = -0.03 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 94.4% within limits 5.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |