| Uracil phosphoribosyltransferase, putative [Q4Q3A1] | |
|---|---|
| Systematic Name | LmjF.34.1040 [Leishmania major] |
| Gene Name | LMJF_34_1040 |
| Molecular Weight | 27179 Da |
| Protein Sequence Size | 242 |
| Function | |
| Charge | -3.5 |
| Isoelectric Point | 5.156 pH |
| Description | Uracil phosphoribosyltransferase, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q3A1|Q4Q3A1_LEIMA Uracil phosphoribosyltransferase, putative - Leishmania major. SQQEGTSPTDRESTMQILNMFPGHLHLLPQTPQLHFLFTVIRDVETQRTDFIFYSERIIR LIFEAALCLIPVKPFNVITPVGAVYRGVRPDDRGIIGVSIMRAGESMERVLREMCPGVRI GKILVQRDETSTDKTPDARFTYSKLPTDVASRRVLLLDPMCATGGSVIKATEILINEYGV LEEDIIFLNLISAPAGIRKYLGRFPKIQIVTAAIDDDLDENRYIVPGLGDFGDRYFGTIS E |
| DNA Sequence | >LmjF34.1040 |||uracil phosphoribosyltransferase, putative|Leishmania major|chr 34|||Manual ATGTCTCAAC AGGAAGGCAC CTCGCCAACG GATCGCGAGA GCACCATGCA GATTCTGAACATGTTCCCCG GACACCTCCA CTTGCTGCCA CAGACGCCGC AGCTTCATTT CCTCTTCACTGTCATCCGCG ACGTGGAGAC TCAGCGCACG GACTTCATCT TCTACTCAGA GCGCATCATACGCCTCATCT TTGAGGCGGC GCTGTGCTTG ATCCCTGTGA AGCCGTTTAA TGTCATCACACCAGTAGGTG CTGTGTACAG GGGTGTTCGG CCGGACGACC GCGGCATCAT CGGCGTCTCCATCATGCGTG CTGGCGAGTC GATGGAGCGC GTGCTGCGTG AGATGTGCCC CGGTGTCCGCATCGGCAAGA TCCTCGTTCA ACGCGACGAG ACGAGCACCG ACAAGACTCC CGATGCACGCTTCACATATA GCAAGCTGCC CACAGATGTA GCCTCGCGCC GCGTGCTGCT GCTGGACCCAATGTGCGCGA CCGGTGGGAG CGTCATCAAG GCGACGGAGA TCCTGATCAA CGAGTACGGCGTGCTCGAGG AGGACATCAT CTTCTTGAAC CTTATCTCCG CCCCCGCAGG AATCAGGAAGTATCTCGGTC GGTTCCCCAA AATCCAGATT GTGACCGCCG CCATCGACGA CGACTTGGATGAGAACAGGT ACATCGTGCC CGGCCTCGGT GACTTTGGCG ACCGCTATTT CGGCACGATATCGGAGTGA |
| Uracil phosphoribosyltransferase, putative Q4Q3A1] | |
|---|---|
| Metabolite Information | pyrimidine salvage |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K00761 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | uridine-cytidine kinase 1-like 1 [Homo sapiens] | 41 | 1e-38 | 156 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| upp uracil phosphoribosyltransferase | Mycoplasma genitalium | 33% | 4e-23 | 102 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 6-11; 118-123; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 2-5; 8-11; 10-13; 131-134; 239-242; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 10-12; 47-49; 56-58; 133-135; 152-154; | PS00005 | |
| Uracil phosphoribosyltransferase, putative [Q4Q3A1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1upuD | |
| Percent Identity | 54% | |
| Target Region | 11-242 | |
| Template Region | 21-224 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ARG | 118 | Sidechain |
| THR | 126 | Sidechain |
| ASP | 221 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14265-44-2 | PHOSPHATE ION | 94.971 | O4 P | [O-]P([O-])([O-])=O | 1upu |
| 58-97-9 | URIDINE-5'-MONOPHOSPHATE | 324.181 | C9 H13 N2 O9 P | O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)COP(=O)(O) | 1upu |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/189192/Q4Q3A1.pdb 2.0 232 = residues | | = | *| Ramachandran plot: 93.0% core 6.0% allow 0.5% gener 0.5% = disall | | = | *| All Ramachandrans: 7 labelled residues (out of 230) = | +| Chi1-chi2 plots: 4 labelled residues (out of 144) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 2 | *| Bond len/angle: 5.2 Morris et al class: 1 = 1 2 | +| 2 cis-peptides = | | G-factors Dihedrals: 0.04 Covalent: -0.16 Overall: = -0.04 | | = | | M/c bond lengths: 98.4% within limits 1.6% highlighted = | | M/c bond angles: 93.3% within limits 6.7% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |