| NAD dependent deacetylase, putative [Q4Q2Y6] | |
|---|---|
| Systematic Name | LmjF.34.2140 [Leishmania major] |
| Gene Name | SIR2rp3 |
| Molecular Weight | 26775 Da |
| Protein Sequence Size | 243 |
| Function | |
| Charge | 1.5 |
| Isoelectric Point | 6.8571 pH |
| Description | NAD dependent deacetylase, putative (Transcriptional regulator, sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbenzimidazole (Cobb) protein). |
| Subcellular Location | chromatin silencing complex[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q2Y6|Q4Q2Y6_LEIMA NAD dependent deacetylase, putative (Transcriptional regulator, sir2 family protein, nicotinic acid mononucleotide 5,6- dimethylbenzimidazole (Cobb) protein) - Leishmania major. KACRCITILTGAGISAESGISTFRDSNGLWCNHHVEDVASPDAFIRNPALVQLFYNERRR NLLLSSVKPNKAHTALAKLEEELSGKGKVFIVTQNVDNLHERAGSKNVLHMHGELLKARC TATGNVFEWQKDIVGDVDRCPDCGFLGTLRPHIVWFGEMPLCMDEIESILSTTDLFVAIG TSGNVYPAAGFVKRAQFYGATTLELNLQEGSNSTLFQESIYGKASSIVPTWVDQVLKESL KK |
| DNA Sequence | >LmjF34.2140 |||NAD dependent deacetylase, putative|Leishmania major|chr 34|||Manual ATGAAAGCGT GCCGGTGTAT CACCATCCTC ACCGGCGCCG GCATCTCTGC TGAATCGGGAATATCCACCT TTCGCGATAG CAACGGACTC TGGTGCAACC ATCATGTCGA GGACGTAGCGTCTCCGGACG CCTTCATCAG AAACCCGGCT CTCGTGCAGC TCTTCTACAA CGAGCGTCGCCGCAATCTTT TGCTAAGCTC TGTCAAGCCG AACAAGGCGC ACACGGCGCT GGCCAAGTTAGAAGAGGAGC TGAGTGGAAA GGGGAAGGTT TTTATTGTCA CTCAGAATGT GGACAACCTGCATGAGCGCG CCGGCTCGAA AAATGTGCTG CACATGCACG GCGAGCTTCT GAAGGCCCGCTGCACAGCCA CGGGGAACGT CTTTGAATGG CAGAAGGACA TTGTGGGAGA TGTTGACCGCTGCCCCGACT GCGGTTTTCT TGGCACCTTG CGCCCGCACA TTGTTTGGTT TGGTGAGATGCCGCTCTGCA TGGACGAGAT CGAGTCGATA CTGTCGACGA CGGATCTCTT TGTTGCCATCGGCACCTCCG GAAACGTGTA CCCCGCCGCC GGGTTTGTAA AGCGGGCGCA GTTTTACGGTGCGACGACGC TTGAGCTGAA TCTTCAGGAG GGCTCCAACA GCACGCTCTT TCAGGAGTCCATCTACGGCA AAGCAAGCAG CATTGTGCCC ACATGGGTGG ACCAAGTGCT GAAAGAGAGCTTGAAAAAAT GA |
| NAD dependent deacetylase, putative Q4Q2Y6] | |
|---|---|
| Metabolite Information | chromatin silencing; regulation of transcription, DNA-dependent |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01463 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | sirtuin 5 isoform 1 [Homo sapiens] | 37 | 1e-40 | 163 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| murG UDP-N-acetylglucosamine-N-acetylmuramyl- | Bacillus subtilis | 52% | 2.4 | 26.6 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 213-216; | PS00722 | |
| PDOC50305 | Sirtuin catalytic domain profile | 41.472 | 1-241 | PS50305 |
| PDOC00002 | The rule PS00002 has been deleted from the PROSITE database | 85-88; | PS00002 | |
| Acylation | N-myristoylation site | 12-17; 29-34; 181-186; 211-216; | PS00008 | |
| Glycosylation | N-glycosylation site | 213-216; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 23-26; 172-175; 202-205; 231-234; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 23-25; 67-69; 85-87; 149-151; 240-242; | PS00005 | |
| NAD dependent deacetylase, putative [Q4Q2Y6] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1s5pA | |
| Percent Identity | 57% | |
| Target Region | 1-243 | |
| Template Region | 40-225 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 23713-49-7 | ZINC ION | 65.409 | Zn | [Zn+2] | 1s5p |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
|
|
|
| Modeled Protein | Template Structure |
|
|
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1295826/Q4Q2Y6.pdb 2.0 243 = residues | | = | +| Ramachandran plot: 93.9% core 5.1% allow 0.9% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 241) = | +| Chi1-chi2 plots: 2 labelled residues (out of 140) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.5 Bad contacts: = 2 | *| Bond len/angle: 10.2 Morris et al class: 1 = 1 2 | +| 2 cis-peptides = | | G-factors Dihedrals: 0.12 Covalent: -0.23 Overall: = -0.01 | | = | | M/c bond lengths: 98.7% within limits 1.3% highlighted = | *| M/c bond angles: 94.0% within limits 6.0% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |