| Ruvb-like 1 DNA helicase, putative [Q4Q2J4] | |
|---|---|
| Systematic Name | LmjF.34.3500 [Leishmania major] |
| Gene Name | LMJF_34_3500 |
| Molecular Weight | 50323 Da |
| Protein Sequence Size | 459 |
| Function | |
| Charge | -4 |
| Isoelectric Point | 5.9806 pH |
| Description | Ruvb-like 1 DNA helicase, putative (EC 3.6.1.-). |
| Subcellular Location | nucleus[Predict] |
| E. C. Number | 3.6.1.- |
| Sequence | >tr|Q4Q2J4|Q4Q2J4_LEIMA Ruvb-like 1 DNA helicase, putative (EC 3.6.1.-) - Leishmania major. SGIKIEEVISTTKKERVAAHSHVKGLGLNPDGTTKHIADGFVGQEKAREAAGIAVELIRS KKMAGRALLFAGPPGTGKTALALGIAKELGPKVPFCPMVGSEVYSAEVKKTEVLMENFRR AIGLRIKENKEVYEGEVTELRAEETDNPLGGYGKSISHVIITLKSQKGSKLLKLDAAIYE SLEKEKVSVGDVIYIEASSGAVKRVGRSDAYIGDHDLEADEYVPIPKGDVHKKKEVIQDV TLHDLDMANAKPSQGQDALSIVSSMMRHKKTEVTEKLRQEINKVVNKYIDQGVAELVPGV LFIDEVHMLDIECFTYLNKALESTLAPVVIFATNRGSCRIRGTEIRAPHGMPTDLLDRLL IIRTMNYDVSEITSIVEIRAHVEGVKISEAALTKLGIIGESTSLRFVVQLLTPALIIAET NGREMLEEEDVDLVAELFKDGKASARQLQDHAEEYVYQ |
| DNA Sequence | >LmjF34.3500 |||ruvb-like 1 DNA helicase, putative|Leishmania major|chr 34|||Manual ATGTCCGGCA TCAAAATCGA GGAGGTCATC TCGACCACCA AGAAGGAGCG GGTAGCAGCGCACAGCCACG TAAAGGGGCT TGGCCTTAAC CCGGACGGGA CGACGAAGCA CATCGCCGACGGTTTCGTCG GCCAGGAGAA GGCGCGCGAG GCGGCCGGCA TTGCGGTGGA GCTGATCCGCTCCAAGAAGA TGGCAGGTCG GGCGCTACTG TTTGCGGGGC CGCCGGGCAC CGGCAAGACGGCGCTGGCCC TCGGTATTGC CAAGGAGCTG GGTCCCAAGG TGCCCTTCTG CCCAATGGTCGGCAGCGAGG TGTACAGCGC GGAGGTGAAA AAGACGGAGG TTCTCATGGA GAACTTCCGCCGCGCCATCG GGCTACGCAT CAAAGAGAAC AAAGAGGTTT ACGAGGGAGA GGTGACTGAGCTGCGCGCCG AGGAGACGGA CAACCCGCTC GGCGGTTATG GCAAGTCCAT CTCGCATGTCATCATCACCC TCAAGTCGCA GAAGGGGTCC AAGTTGCTGA AGCTGGATGC GGCCATCTATGAGAGCCTGG AGAAAGAGAA GGTGTCCGTC GGTGACGTCA TCTACATCGA GGCAAGCTCTGGCGCTGTGA AGCGGGTGGG CCGCAGCGAT GCGTACATCG GTGACCACGA CCTGGAGGCGGACGAGTACG TGCCGATCCC GAAAGGGGAC GTGCACAAGA AGAAAGAGGT GATCCAGGACGTAACGCTGC ACGATCTCGA CATGGCAAAT GCGAAGCCCA GCCAGGGACA GGATGCCCTGTCAATTGTGA GCAGCATGAT GCGGCACAAA AAGACGGAGG TGACAGAGAA GCTGCGCCAGGAGATCAACA AGGTTGTGAA CAAATACATT GACCAGGGCG TCGCTGAGCT CGTGCCCGGCGTCCTCTTCA TCGATGAAGT GCACATGCTA GATATTGAGT GCTTCACCTA CCTCAACAAGGCGCTGGAGT CGACCCTCGC ACCGGTCGTC ATATTCGCCA CCAACCGCGG CAGTTGCCGCATTCGCGGGA CGGAGATTCG CGCGCCGCAC GGGATGCCAA CAGATTTGCT AGATCGTCTCCTCATCATTC GCACCATGAA CTACGACGTG AGCGAAATTA CGTCGATAGT TGAGATCCGTGCCCATGTGG AGGGGGTGAA GATATCCGAG GCGGCTCTGA CCAAGCTCGG CATCATCGGCGAGAGCACGT CGCTGCGCTT CGTTGTGCAA CTGCTGACGC CGGCGCTCAT CATTGCCGAGACGAATGGCC GCGAGATGCT CGAGGAGGAA GATGTGGATC TGGTGGCTGA ACTCTTCAAGGACGGCAAGG CATCTGCCCG TCAGCTGCAG GACCACGCAG AGGAATACGT ATACCAGTGA |
| Ruvb-like 1 DNA helicase, putative Q4Q2J4] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K04499 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | TATA binding protein interacting protein 49 kDa [Homo sapiens] | 67 | 1e-173 | 604 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YDR190c RUVB-like protein | Saccharomyces cerevisiae | 62% | 1e-158 | 553 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 73-80; | PS00017 | |
| Acylation | N-myristoylation site | 44-49; 76-81; 385-390; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 13-16; 189-192; 242-245; 375-378; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 12-14; 13-15; 34-36; 61-63; 77-79; 163-165; 166-168; 275-277; 334-336; 338-340; 404-406; 445-447; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 127-141; 173-187; 216-230 | PS00003 | |
| Ruvb-like 1 DNA helicase, putative [Q4Q2J4] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2c9oC | |
| Percent Identity | 67% | |
| Target Region | 10-459 | |
| Template Region | 7-311 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 58-64-0 | ADENOSINE-5'-DIPHOSPHATE | 427.201 | C10 H15 N5 O10 P2 | O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 2c9o |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1209160/Q4Q2J4.pdb 2.0 450 = residues | | = | *| Ramachandran plot: 95.5% core 3.8% allow 0.3% gener 0.5% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 448) = | | Chi1-chi2 plots: 0 labelled residues (out of 268) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 4.0 Bad contacts: = 3 | +| Bond len/angle: 4.9 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.16 Covalent: -0.14 Overall: = 0.05 | | = | | M/c bond lengths: 99.5% within limits 0.5% highlighted = | | M/c bond angles: 93.9% within limits 6.1% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |