| Geranylgeranyltransferase, putative [Q4Q2D8] | |
|---|---|
| Systematic Name | LmjF.34.4030 [Leishmania major] |
| Gene Name | LMJF_34_4030 |
| Molecular Weight | 36482 Da |
| Protein Sequence Size | 330 |
| Function | |
| Charge | -8 |
| Isoelectric Point | 5 pH |
| Description | Geranylgeranyltransferase, putative (EC 2.5.1.-). |
| Subcellular Location | CAAX-protein geranylgeranyltransferase complex[Predict] |
| E. C. Number | 2.5.1.- |
| Sequence | >tr|Q4Q2D8|Q4Q2D8_LEIMA Geranylgeranyltransferase, putative (EC 2.5.1.-) - Leishmania major. EESAAPCGPIAADLHHKFVHELDDNTQWKAQHLKMNGVYWGLSSLVLLHRMDYKPGDVVD FVLSCYNGDGGFGGNADMDSHLLHTMSAVQLLCMFDAVARIDVERTARWIASMQLPDGSF QGDEWGEVDTRFSYIALSCLRLLGRCECVDVEAAVQYVLRCQNWDGGFGVSPGAESHAGQ IFCCVGALCIANALDRIDRDRVAAWLAMRQLPSGGLNGRPEKKADVCYSWWVVSSLSALG RTSWIDKEALFQYILSCQDTQDGGFSDKPGNQPDVYHTFFGLCGLSLLGYEGYKLNPINP VYALSYDILDRLNIAPEHGSQVGRRVPRS |
| DNA Sequence | >LmjF34.4030 |||geranylgeranyltransferase, putative|Leishmania major|chr 34|||Manual ATGGAAGAGT CGGCTGCGCC ATGTGGCCCC ATTGCGGCGG ACTTGCACCA CAAGTTCGTGCACGAGCTCG ACGACAACAC GCAATGGAAG GCGCAGCATC TCAAGATGAA CGGCGTCTACTGGGGACTCA GCTCACTTGT GCTGCTGCAC CGGATGGACT ATAAGCCGGG CGACGTTGTGGATTTTGTGC TGTCGTGCTA CAACGGCGAC GGCGGCTTTG GCGGCAATGC CGACATGGACTCCCACTTGC TGCACACCAT GTCCGCGGTG CAGCTGCTGT GCATGTTCGA CGCAGTCGCGCGCATTGATG TGGAGCGGAC GGCTCGCTGG ATTGCGTCGA TGCAGCTGCC GGACGGCTCCTTTCAAGGGG ACGAGTGGGG CGAGGTGGAC ACTCGCTTCT CCTACATCGC GCTCAGTTGCCTTCGCCTGC TGGGGCGCTG CGAGTGCGTC GATGTCGAGG CGGCTGTCCA GTATGTGCTGCGGTGCCAGA ACTGGGACGG CGGTTTCGGC GTCTCGCCAG GGGCGGAGAG CCACGCAGGCCAGATCTTCT GCTGCGTGGG TGCACTGTGC ATAGCGAATG CCCTCGATCG CATCGACAGGGATCGCGTGG CGGCGTGGCT GGCGATGCGC CAGCTTCCCT CCGGCGGCCT CAACGGGCGGCCGGAGAAAA AGGCGGACGT GTGCTACAGC TGGTGGGTTG TATCGTCCCT CTCCGCTCTTGGCCGCACAA GCTGGATTGA CAAGGAGGCA CTGTTTCAGT ACATCCTCAG CTGCCAGGACACGCAGGACG GCGGATTTTC TGACAAGCCA GGCAACCAAC CGGATGTGTA TCACACCTTCTTTGGCCTGT GCGGGCTTAG CCTTCTGGGG TACGAGGGGT ACAAGTTGAA TCCCATCAACCCCGTGTACG CGCTGTCCTA CGACATCTTG GATCGGCTGA ACATCGCACC AGAGCACGGCTCGCAGGTTG GACGGCGTGT TCCGCGATCA TGA |
| Geranylgeranyltransferase, putative Q4Q2D8] | |
|---|---|
| Metabolite Information | protein modification |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K05956 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | Rab geranylgeranyltransferase, beta subunit [Homo sapiens] | 47 | 2e-88 | 322 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YPR176c geranylgeranyltransferase type II beta subunit | Saccharomyces cerevisiae | 47% | 9e-81 | 294 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| Acylation | N-myristoylation site | 38-43; 71-76; 119-124; 170-175; 180-185; 215-220; 320-325; | PS00008 | |
| Amidation | Amidation site | 323-326; | PS00009 | |
| Phosphorylation | Casein kinase II phosphorylation site | 244-247; 257-260; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 107-109; 267-269; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 223-229; | PS00007 | |
| Geranylgeranyltransferase, putative [Q4Q2D8] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1ltxB | |
| Percent Identity | 47% | |
| Target Region | 1-322 | |
| Template Region | 6-318 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| TYR | 229 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16887-00-6 | CHLORIDE ION | 35.453 | Cl | [Cl-] | 1ltx |
| FARNESYL | 206.367 | C15 H26 | C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C | 1ltx | |
| 23713-49-7 | ZINC ION | 65.409 | Zn | [Zn+2] | 1ltx |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1958850/Q4Q2D8.pdb 2.0 321 = residues | | = | +| Ramachandran plot: 90.6% core 8.7% allow 0.7% gener 0.0% = disall | | = | +| All Ramachandrans: 6 labelled residues (out of 319) = | +| Chi1-chi2 plots: 4 labelled residues (out of 186) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.9 Bad contacts: = 3 | *| Bond len/angle: 9.1 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.11 Covalent: -0.13 Overall: = 0.02 | | = | | M/c bond lengths: 98.9% within limits 1.1% highlighted = | *| M/c bond angles: 94.7% within limits 5.3% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |