| Protein serine/threonine phosphatase, putativee [Q4Q2C2] | |
|---|---|
| Systematic Name | LmjF.34.4190 [Leishmania major] |
| Gene Name | LMJF_34_4190 |
| Molecular Weight | 35588 Da |
| Protein Sequence Size | 309 |
| Function | |
| Charge | -8 |
| Isoelectric Point | 5.2 pH |
| Description | Protein serine/threonine phosphatase, putativee (EC 3.1.3.16). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.1.3.16 |
| Sequence | >tr|Q4Q2C2|Q4Q2C2_LEIMA Protein serine/threonine phosphatase, putativee (EC 3.1.3.16) - Leishmania major. NLDAWEEKVRLVQPLEMKEMQLLLRTAVNLLIEESNVQGVHLPVTICGDIHGQFLDLLRL FEVAGEIRRETGSMNYIFLGDLVDRGRNSVEVLTFLLILKLKYPHKITLIRGNHETRQVT TMYGFYDECAEKFGTVEIWKLCTEVFDCMPIAALIEGKSLCIHGGLSPEIRSVDQIRLLN RRQEIPNEGPFSDLVWSDPENVDGWVVSQRGAGFLFGASVTQEFIHRNRLNLIARAHQLV HEGFKYHFDEEYLCTVWSAPNYCYRCGNLASVLRIYEDHSCEFVVFKEVEAQITLSDEPR TKEPAYFL |
| DNA Sequence | >LmjF34.4190 |||protein serine/threonine phosphatase, putativee|Leishmania major|chr 34|||Manual ATGAACCTCG ATGCGTGGGA GGAAAAGGTG CGCCTTGTGC AGCCGTTGGA GATGAAGGAAATGCAGCTCC TGCTTCGCAC AGCCGTAAAT CTGCTCATCG AGGAGAGCAA CGTGCAAGGGGTGCACCTTC CTGTCACCAT CTGCGGTGAC ATTCACGGTC AGTTCCTCGA TCTTCTTCGGCTCTTCGAGG TGGCAGGGGA AATTCGTCGT GAGACCGGCA GCATGAACTA CATCTTCCTAGGCGACCTCG TCGATCGGGG GCGCAACAGT GTCGAGGTAC TCACCTTTCT TCTGATCCTGAAGCTCAAAT ACCCGCACAA AATCACTCTC ATCCGCGGCA ACCACGAAAC TAGGCAGGTCACCACCATGT ACGGCTTCTA CGATGAGTGT GCTGAGAAGT TCGGCACGGT GGAGATATGGAAGTTGTGCA CAGAGGTGTT TGACTGCATG CCGATCGCCG CACTCATCGA GGGCAAAAGTCTTTGCATTC ATGGCGGCCT CTCTCCGGAA ATCCGTTCGG TTGATCAAAT CCGGTTGCTGAATCGGCGGC AAGAGATTCC GAACGAAGGA CCCTTCTCAG ACCTCGTCTG GTCAGACCCGGAGAACGTCG ACGGCTGGGT GGTGTCGCAG CGTGGCGCCG GCTTTCTTTT CGGCGCCTCCGTCACGCAAG AGTTTATCCA CCGCAACCGG CTCAACCTCA TCGCCCGCGC CCACCAGCTCGTCCACGAGG GATTCAAGTA CCACTTCGAC GAGGAATACC TCTGCACAGT GTGGTCAGCGCCAAACTACT GCTATCGATG CGGTAACCTC GCCAGTGTCC TGCGCATCTA CGAGGACCACTCGTGCGAGT TTGTCGTCTT TAAGGAGGTG GAGGCACAGA TCACTCTCTC TGACGAGCCAAGGACGAAGG AGCCGGCCTA CTTTCTGTAG |
| Protein serine/threonine phosphatase, putativee Q4Q2C2] | |
|---|---|
| Metabolite Information | |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01090 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 6, catalytic subunit [Homo sapiens] | 55 | 1e-95 | 347 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER133w serthr phosphoprotein phosphatase 1, catalytic chain | Saccharomyces cerevisiae | 40% | 8e-66 | 244 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 153-160; | PS00017 | |
| PDOC00115 | Serine/threonine specific protein phosphatases signature | 111-116; | PS00125 | |
| Acylation | N-myristoylation site | 113-118; 218-223; 268-273; | PS00008 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 69-72; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 198-201; 295-298; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 209-211; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 246-253; 301-307; | PS00007 | |
| Protein serine/threonine phosphatase, putativee [Q4Q2C2] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2nppF | |
| Percent Identity | 46% | |
| Target Region | 1-309 | |
| Template Region | 2-308 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 85 | Sidechain |
| ARG | 86 | Sidechain |
| ASN | 114 | Sidechain |
| HIS | 115 | Sidechain |
| ARG | 211 | Sidechain |
| HIS | 238 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 2npp |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2623212/Q4Q2C2.pdb 2.0 309 = residues | | = | *| Ramachandran plot: 85.5% core 12.7% allow 0.4% gener 1.4% = disall | | = | *| All Ramachandrans: 12 labelled residues (out of 307) = | +| Chi1-chi2 plots: 1 labelled residues (out of 202) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.3 Bad contacts: = 5 | *| Bond len/angle: 5.4 Morris et al class: 1 = 1 2 | +| 2 cis-peptides = | | G-factors Dihedrals: -0.03 Covalent: -0.12 Overall: = -0.06 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 94.2% within limits 5.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |