| Eukaryotic translation initiation factor 6 (EIF-6), putative [Q4Q1Y7] | |
|---|---|
| Systematic Name | LmjF.36.0890 [Leishmania major] |
| Gene Name | EIF6 |
| Molecular Weight | 27129 Da |
| Protein Sequence Size | 249 |
| Function | |
| Charge | -7 |
| Isoelectric Point | 4.8257 pH |
| Description | Eukaryotic translation initiation factor 6 (EIF-6), putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q1Y7|Q4Q1Y7_LEIMA Eukaryotic translation initiation factor 6 (EIF-6), putative - Leishmania major TLRTRFESSDDIGVFSRLTNAYCLVAAGASQNFYSVFEQELANHICVVYTSIGDARVIGR LTIGNRHGLIVPSITTDQELQHLRNSLPDSVKVQRVEERLSALGNCVVCNDHVALIHTDL SRETEEVIRDTLQVQTFRTSIAENALVGSYAVATNKGCMVHPKTPAQDMDEISSLLQVPV VAGTINRGNAAIGSGLVVNDWAAFCGLNTTATEITVVERIFQLRRETAGGDEGNLLQNVR ETLVDELA |
| DNA Sequence | >LmjF36.0890 |||Eukaryotic translation initiation factor 6 (eIF-6), putative|Leishmania major|chr 36|||Manual ATGACGCTGC GCACCCGCTT CGAGAGCTCC GATGATATCG GCGTCTTCTC CCGCCTCACCAACGCGTACT GCCTGGTGGC CGCTGGCGCG TCGCAAAACT TCTACTCAGT GTTCGAACAGGAGTTGGCAA ACCACATATG CGTCGTGTAC ACGTCCATCG GTGATGCACG CGTGATTGGCCGCCTTACCA TCGGCAACCG CCACGGCCTC ATCGTTCCGT CCATCACGAC GGATCAGGAGCTGCAGCACC TCCGCAACTC GCTACCCGAC TCCGTGAAAG TGCAGCGTGT CGAAGAGCGTCTCTCTGCAC TAGGCAACTG TGTGGTGTGC AACGACCACG TAGCGCTCAT CCACACAGACCTGAGCCGTG AGACAGAGGA GGTGATTCGC GATACCCTGC AGGTTCAGAC GTTCCGCACCTCCATCGCGG AGAACGCCCT AGTGGGTAGT TACGCCGTAG CGACGAATAA GGGTTGCATGGTGCACCCCA AGACCCCTGC ACAGGACATG GACGAGATAT CGTCCCTGCT GCAGGTGCCGGTCGTGGCGG GCACGATCAA CCGCGGCAAT GCTGCCATCG GCTCTGGTCT TGTAGTGAACGACTGGGCCG CCTTTTGTGG TCTCAACACG ACGGCGACAG AAATCACCGT CGTGGAGCGCATTTTCCAGC TGCGCCGTGA GACCGCCGGT GGCGACGAAG GCAACTTGCT GCAGAATGTCCGCGAGACCC TGGTGGACGA GCTGGCGTAG |
| Eukaryotic translation initiation factor 6 (EIF-6), putative Q4Q1Y7] | |
|---|---|
| Metabolite Information | translational initiation |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K03264 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | integrin beta 4 binding protein isoform a [Homo sapiens] | 58 | 1e-83 | 306 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YPR016c translation initiation factor 6 (eIF6) | Saccharomyces cerevisiae | 60% | 1e-83 | 303 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 209-212; | PS00722 | |
| Acylation | N-myristoylation site | 29-34; 65-70; 196-201; 207-212; 230-235; | PS00008 | |
| Glycosylation | N-glycosylation site | 209-212; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 225-228; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 5-8; 9-12; 36-39; 52-55; 77-80; 87-90; 141-144; 211-214; 216-219; 243-246; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 2-4; 91-93; 137-139; 155-157; | PS00005 | |
| Eukaryotic translation initiation factor 6 (EIF-6), putative [Q4Q1Y7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1g62A | |
| Percent Identity | 63% | |
| Target Region | 1-223 | |
| Template Region | 1-223 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
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| Residue | Active Site Number | Functional Part |
| Co-Factor | |
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| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1580744/Q4Q1Y7.pdb 2.0 223 = residues | | = | +| Ramachandran plot: 91.1% core 7.9% allow 1.0% gener 0.0% = disall | | = | +| All Ramachandrans: 4 labelled residues (out of 221) = | +| Chi1-chi2 plots: 2 labelled residues (out of 119) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | | Residue properties: Max.deviation: 2.6 Bad contacts: = 3 | +| Bond len/angle: 4.9 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.06 Covalent: -0.11 Overall: = -0.01 | | = | | M/c bond lengths:100.0% within limits 0.0% highlighted = | | M/c bond angles: 94.5% within limits 5.5% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |