| Fructose-bisphosphate aldolase [Q4Q1V0] | |
|---|---|
| Systematic Name | LmjF.36.1260 [Leishmania major] |
| Gene Name | ALD |
| Molecular Weight | 40828 Da |
| Protein Sequence Size | 371 |
| Function | |
| Charge | 9.5 |
| Isoelectric Point | 8.7673 pH |
| Description | Fructose-bisphosphate aldolase. |
| Subcellular Location | glycosome[Predict] |
| E. C. Number | 4.1.2.13 |
| Sequence | >tr|Q4Q1V0|Q4Q1V0_LEIMA Fructose-bisphosphate aldolase - Leishmania major SRVTIFQSQLPACNRIKTPYESELIATVKKLTTPGKGLLAADESIGSCTKRFEPIGLSNT EEHRRQYRALMLEAEGLEQYISGVILHDETVSQKASNGKTFPEYLTARGVVPGIKTDMGL CPLLEGAEGEQMTEGLDGYVKRASVYYKKGCRFCKWRNVYKIQNGTVSEPAVRFNAETLA RYAILSQMSGLVPIVEPEVMIDGKHDIDTCQRVSEHVWREVVAALQRHGVIWEGCLLKPN MVVPGAESGQTAAPEQVAHYTVMTLARTMPAMLPGVMFLSGGLSEVQASEYLNAINNSPL PRPYFLSFSYARALQSSALKAWGGKDSGVAAGRRAFLHRARMNSMAQLGKYKRADDDASS SSLYVKGNIY |
| DNA Sequence | >LmjF36.1260 |ALD||fructose-1,6-bisphosphate aldolase|Leishmania major|chr 36|||Manual ATGTCGCGTG TGACGATCTT TCAGAGCCAG CTGCCGGCGT GCAACCGCAT CAAGACGCCGTACGAATCGG AGCTGATTGC GACGGTCAAG AAGCTGACGA CACCAGGCAA GGGCCTGCTGGCGGCGGACG AGTCGATCGG CTCGTGCACG AAGCGATTCG AGCCGATCGG GCTGAGCAACACGGAGGAGC ACCGCCGGCA GTACCGTGCG CTGATGCTTG AGGCGGAGGG CCTCGAGCAGTACATCAGCG GCGTCATCCT GCACGACGAG ACGGTTAGCC AGAAAGCGAG CAACGGGAAGACGTTCCCAG AGTACCTGAC GGCGCGCGGT GTTGTGCCTG GGATCAAGAC GGACATGGGCCTGTGTCCGC TGCTCGAGGG CGCAGAGGGG GAGCAGATGA CGGAGGGCCT GGACGGCTACGTCAAGCGCG CGTCTGTGTA CTACAAGAAA GGCTGCCGCT TCTGCAAGTG GCGCAACGTGTACAAAATCC AAAACGGAAC GGTGTCGGAG CCTGCAGTGC GCTTCAACGC GGAGACGCTCGCGCGCTACG CGATCCTGTC GCAGATGAGC GGGCTTGTGC CGATCGTGGA ACCGGAAGTGATGATTGACG GCAAGCACGA TATCGACACT TGCCAGCGCG TTTCAGAGCA TGTGTGGCGCGAGGTGGTGG CGGCGCTGCA GCGCCACGGC GTTATCTGGG AGGGTTGCCT GCTGAAGCCGAACATGGTGG TTCCCGGCGC CGAATCCGGC CAGACGGCGG CACCGGAACA GGTGGCGCACTACACAGTGA TGACGCTTGC GCGCACGATG CCGGCGATGC TACCTGGCGT GATGTTCCTGTCCGGTGGGC TGAGCGAGGT CCAGGCGAGC GAGTACCTGA ACGCAATTAA CAACAGCCCGCTACCGCGGC CGTATTTCCT GAGTTTCTCG TACGCGCGCG CGCTTCAATC TTCTGCTCTGAAGGCGTGGG GTGGAAAGGA CTCCGGCGTT GCTGCCGGAC GCCGCGCCTT CTTACACCGCGCGCGCATGA ACTCGATGGC GCAGCTTGGC AAGTACAAGC GCGCCGATGA CGATGCCTCCTCCTCGTCCC TGTACGTCAA AGGCAACATC TATTAA |
| Fructose-bisphosphate aldolase Q4Q1V0] | |
|---|---|
| Metabolite Information | glycolysis |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K01623 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | fructose-bisphosphate aldolase C [Homo sapiens] | 48 | 2e-84 | 310 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| Rv2174 Possible conserved integral membrane protein | Mycobacterium tuberculosis H37Rv | 50% | 7.2 | 25.8 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 165-168; | PS00722 | |
| PDOC00143 | Fructose-bisphosphate aldolase class-I active site | 231-241; | PS00158 | |
| Acylation | N-myristoylation site | 38-43; 57-62; 110-115; 151-156; 246-251; 324-329; 329-334; | PS00008 | |
| Amidation | Amidation site | 332-335; | PS00009 | |
| Glycosylation | N-glycosylation site | 165-168; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 30-33; 142-145; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 19-22; 59-62; 101-104; 167-170; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 28-30; 50-52; 93-95; 107-109; | PS00005 | |
| Fructose-bisphosphate aldolase [Q4Q1V0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2qdhD | |
| Percent Identity | 95% | |
| Target Region | 1-357 | |
| Template Region | 1-358 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 43 | Sidechain |
| GLU | 197 | Sidechain |
| LYS | 239 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| D-MANNITOL-1,6-DIPHOSPHATE | 342.132 | C6 H16 O12 P2 | O=P(O)(O)OCC(O)C(O)C(O)C(O)COP(=O)(O)O | 2qdh | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/398734/Q4Q1V0.pdb 2.0 358 = residues | | = | | Ramachandran plot: 95.5% core 4.5% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 356) = | +| Chi1-chi2 plots: 1 labelled residues (out of 199) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.7 Bad contacts: = 1 | *| Bond len/angle: 6.6 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.19 Covalent: -0.06 Overall: = 0.10 | | = | | M/c bond lengths: 99.7% within limits 0.3% highlighted = | | M/c bond angles: 95.8% within limits 4.2% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |