| Adenylate kinase, putative [Q4Q1U0] | |
|---|---|
| Systematic Name | LmjF.36.1360 [Leishmania major] |
| Gene Name | LMJF_36_1360 |
| Molecular Weight | 24869 Da |
| Protein Sequence Size | 220 |
| Function | This small ubiquitous enzyme is essential for maintenance and cell growth |
| Charge | 6.5 |
| Isoelectric Point | 9.2 pH |
| Description | Adenylate kinase, putative (EC 2.7.4.3). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.4.3 |
| Sequence | >tr|Q4Q1U0|Q4Q1U0_LEIMA Adenylate kinase, putative (EC 2.7.4.3) - Leishmania major PLFIILFGPPGSGKGTVSHLLVKEYGFVHLSAGNLLREEVLKKSPLGRRCAEIMSEGSLI PDELVVDLVCNRLSEQAVQKHGILLDGFPRNLRQAEVLTARGFKFDMMIFLDVSPEILLD RCLSRRLDPVTGRIYNLKSDPPSPEVADRLQIRSDDTKEKHERRMQIYNSQKATLIAHYS DIIIEINADPEIKVVFKELQKKINKRLQGTTTQVPLAKL |
| DNA Sequence | >LmjF36.1360 |||adenylate kinase, putative|Leishmania major|chr 36|||Manual ATGCCACTGT TTATCATTCT ATTTGGCCCC CCTGGCAGCG GCAAGGGGAC AGTGAGCCATCTGCTCGTAA AAGAGTACGG CTTTGTCCAC TTGAGTGCCG GTAATCTGCT ACGCGAAGAAGTGCTCAAAA AGTCTCCGCT AGGGCGGAGG TGTGCAGAAA TCATGTCCGA AGGGTCCCTGATCCCGGACG AGCTCGTCGT CGACCTCGTG TGCAACCGGC TGAGTGAGCA GGCTGTGCAGAAGCACGGTA TTTTGCTTGA CGGCTTTCCA CGGAACCTGC GGCAGGCAGA GGTGCTCACGGCGCGCGGCT TCAAGTTTGA CATGATGATT TTTCTCGACG TGTCGCCGGA GATTTTGCTCGACCGATGCC TTTCCCGTCG CCTCGACCCG GTGACGGGGC GCATTTACAA CCTCAAGAGCGACCCGCCTT CGCCGGAGGT TGCGGACCGT CTTCAGATCC GCTCCGACGA CACGAAAGAGAAGCACGAGC GTCGCATGCA GATCTACAAC AGTCAGAAGG CAACTCTCAT CGCCCATTACTCTGACATCA TCATTGAGAT CAACGCGGAC CCGGAGATCA AGGTAGTCTT CAAGGAGCTGCAAAAGAAAA TCAACAAGCG GTTGCAGGGC ACCACCACGC AGGTCCCTCT GGCAAAGCTGTAG |
| Adenylate kinase, putative Q4Q1U0] | |
|---|---|
| Metabolite Information | nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | adenylate kinase 2 isoform b [Homo sapiens] | 35 | 1e-26 | 117 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| adk Adenylate kinase (EC 2.7.4.3) | Escherichia coli MG1655 | 37% | 5e-33 | 134 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00104 | Adenylate kinase signature | 84-95; | PS00113 | |
| PDOC00299 | Microbodies C-terminal targeting signal | 218-220; | PS00342 | |
| Acylation | N-myristoylation site | 12-17; | PS00008 | |
| Amidation | Amidation site | 47-50; | PS00009 | |
| Phosphorylation | Protein kinase C phosphorylation site | 13-15; 100-102; 125-127; 132-134; 171-173; | PS00005 | |
| Adenylate kinase, putative [Q4Q1U0] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1zakB | |
| Percent Identity | 41% | |
| Target Region | 1-220 | |
| Template Region | 4-220 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| LYS | 15 | Sidechain |
| ARG | 126 | Sidechain |
| ARG | 154 | Sidechain |
| ASP | 156 | Sidechain |
| ASP | 157 | Sidechain |
| ARG | 165 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| BIS(ADENOSINE)-5'-PENTAPHOSPHATE | 916.367 | C20 H29 N10 O22 P5 | c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)n5cnc6c5ncnc6N)O)O)O)O)N | 1zak | |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2087520/Q4Q1U0.pdb 2.0 218 = residues | | = | | Ramachandran plot: 96.3% core 3.7% allow 0.0% gener 0.0% = disall | | = | +| All Ramachandrans: 1 labelled residues (out of 216) = | +| Chi1-chi2 plots: 2 labelled residues (out of 142) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.1 Bad contacts: = 2 | *| Bond len/angle: 5.2 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.15 Covalent: -0.05 Overall: = 0.08 | | = | | M/c bond lengths: 99.6% within limits 0.4% highlighted = | | M/c bond angles: 95.9% within limits 4.1% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |