| Transitional endoplasmic reticulum ATPase, putative [Q4Q1T9] | |
|---|---|
| Systematic Name | LmjF.36.1370 [Leishmania major] |
| Gene Name | LMJF_36_1370 |
| Molecular Weight | 86839 Da |
| Protein Sequence Size | 784 |
| Function | |
| Charge | -18 |
| Isoelectric Point | 4.9701 pH |
| Description | Transitional endoplasmic reticulum ATPase, putative (Valosin- containing protein homolog). |
| Subcellular Location | cytoplasm; membrane[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q1T9|Q4Q1T9_LEIMA Transitional endoplasmic reticulum ATPase, putative (Valosin- containing protein homolog) - Leishmania major. ADAVGNTNSKVKLNKLIVEEPYNDDNSVVSLNPKRMEELNIFRGDTVLVKGKKHRSTVCI AMEDDECPPEKIKMNKVARRNIRIHLGDTIRIMPCKDVPYGNRVHLLPIDDTVENLTGDL FENFLKPYFLESYRPVKKGDSFVCRGAMRSVEFKVVEVDPGDYCIVSPDTIIHSEGDPIH REDEEALDGVGYDDIGGCRKQLNQIREMVELPIRHPELFKNIGIKPPRGILLYGPPGSGK TLIARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNAPSIIFIDEIDSIAP KREKAQGEVEKRIVSQLLTLMDGMKSRSQVIVMAATNRPNTIDPALRRFGRFDRELDIGV PDETGRLEIIRIHTKNMKLADDIDLEKVAKDSHGFVGADLAQLCTEAAMQCIREKLSIID WEDDTIDAEVMNAMCVTQEHFREAMAKTNPSALRETQVETPNVVWEDVGGLLDVKRELQE LVQYPVEYPWKFEKYGMSPPKGVLFYGPPGCGKTLLAKAIATECQANFISIKGPELLTMW FGESEANVRDVFDKARAAAPCVLFFDELDSVAKSRGAHGDGGASDRVINQILTEMDGMNV KKNVFIIGATNRPDVLDPAIMRPGRLDQLIYIPLPDKASRVAIIKASFRKSPLASDVDVD QIAAATHGFSGADLSGICQRACKMAIRESINKEIQLEELKKSGQLDENADIDPVPEITRA HVEEAMRGARRSVSDADIRRYDMFKTSLQQSRAFGASNPPPAEAAAPAGSGAPPPADDDD LYS |
| DNA Sequence | >LmjF36.1370 |||Transitional endoplasmic reticulum ATPase, putative|Leishmania major|chr 36|||Manual ATGGCCGACG CTGTTGGGAA CACAAACTCG AAGGTGAAGC TAAACAAGCT GATCGTCGAGGAGCCGTACA ATGACGACAA CAGTGTTGTG TCGCTGAACC CGAAGCGGAT GGAGGAGCTGAACATCTTTC GCGGTGACAC CGTTCTCGTG AAGGGCAAGA AGCACCGCAG CACCGTCTGCATCGCGATGG AGGACGACGA GTGCCCGCCG GAAAAAATCA AGATGAACAA AGTCGCGCGCCGCAACATCC GCATTCACCT CGGCGACACC ATTCGCATCA TGCCCTGCAA GGATGTTCCATACGGAAACC GCGTTCACCT GCTGCCAATC GATGACACGG TGGAGAACCT CACTGGTGACTTGTTCGAGA ACTTTTTGAA GCCGTACTTT TTGGAGTCGT ACCGGCCCGT GAAGAAGGGTGACTCCTTCG TCTGCCGTGG CGCTATGCGC TCTGTGGAAT TCAAGGTAGT GGAGGTGGACCCGGGTGATT ACTGCATCGT GTCGCCGGAC ACGATCATCC ACTCCGAGGG TGATCCGATCCATCGAGAGG ACGAGGAGGC GCTTGACGGA GTCGGCTACG ACGACATTGG CGGTTGCCGCAAGCAGCTGA ACCAGATCCG CGAGATGGTC GAGCTCCCCA TTCGCCACCC GGAGCTGTTCAAGAACATTG GCATCAAGCC CCCGCGTGGC ATCTTGCTTT ACGGCCCTCC CGGGAGCGGCAAGACGCTCA TCGCGCGCGC TGTCGCAAAC GAGACGGGCG CCTTTTTCTT CCTCATCAACGGTCCTGAGA TTATGAGCAA GATGGCTGGC GAGTCGGAGA GCAACCTGCG CAAGGCCTTCGAGGAGGCCG AGAAGAACGC GCCGTCGATC ATTTTTATCG ACGAAATCGA CTCCATCGCCCCGAAGCGTG AGAAAGCGCA GGGCGAGGTG GAGAAGCGTA TCGTTTCGCA GCTTCTCACCCTAATGGACG GCATGAAATC GCGCTCGCAG GTGATCGTGA TGGCGGCGAC GAACCGCCCGAACACCATCG ATCCAGCCTT GCGCCGTTTT GGCCGCTTCG ACCGCGAGCT CGACATTGGCGTGCCGGACG AGACTGGTCG CTTGGAGATC ATTCGTATCC ACACCAAGAA CATGAAGCTGGCCGACGACA TTGATCTGGA GAAGGTGGCA AAGGACTCGC ACGGCTTTGT CGGCGCCGATTTGGCGCAGC TCTGCACCGA GGCTGCCATG CAGTGCATTC GCGAGAAGCT GTCCATCATCGACTGGGAGG ATGACACCAT CGATGCCGAG GTGATGAACG CGATGTGTGT AACGCAGGAGCACTTTCGTG AGGCCATGGC GAAGACGAAC CCGTCTGCGC TGCGCGAGAC ACAGGTGGAAACTCCGAACG TCGTCTGGGA GGATGTGGGC GGCCTCCTGG ACGTCAAGCG CGAGCTGCAGGAACTGGTGC AGTACCCCGT CGAGTACCCG TGGAAGTTCG AAAAGTACGG CATGTCGCCGCCGAAGGGTG TCCTCTTCTA CGGACCACCC GGTTGCGGTA AGACGCTCTT GGCCAAGGCGATTGCGACGG AGTGCCAGGC GAACTTCATC TCCATCAAAG GCCCGGAGCT TCTGACAATGTGGTTCGGTG AATCGGAGGC GAATGTGCGC GACGTCTTCG ACAAGGCTCG TGCTGCGGCGCCTTGCGTGC TCTTTTTTGA TGAACTGGAC TCCGTGGCCA AGTCCCGCGG CGCCCACGGCGATGGAGGCG CGAGCGACCG CGTGATCAAC CAAATCCTGA CAGAGATGGA CGGCATGAACGTCAAAAAGA ATGTCTTCAT CATCGGTGCG ACGAACCGGC CAGACGTGCT GGACCCTGCGATCATGCGTC CTGGTCGTCT CGACCAGCTC ATCTACATTC CATTGCCTGA CAAGGCGTCTCGTGTGGCCA TTATCAAGGC GAGCTTCCGC AAGTCGCCGC TAGCCTCCGA CGTCGACGTGGATCAGATTG CCGCCGCCAC GCACGGCTTC TCCGGCGCCG ACTTGTCTGG CATCTGCCAGCGCGCGTGCA AGATGGCAAT CCGCGAGTCG ATCAACAAGG AAATTCAGCT CGAGGAGCTGAAGAAGAGCG GGCAGTTGGA CGAAAACGCT GATATCGACC CGGTGCCGGA GATCACGCGCGCTCATGTGG AGGAGGCAAT GCGCGGTGCC CGCCGGTCCG TCTCTGACGC AGACATTCGCCGCTACGATA TGTTCAAAAC CTCCTTGCAG CAGAGCCGCG CCTTCGGCGC TAGTAACCCACCCCCAGCGG AGGCCGCTGC GCCAGCTGGC AGCGGGGCGC CGCCGCCAGC AGACGACGACGACCTCTACA GCTAA |
| Transitional endoplasmic reticulum ATPase, putative Q4Q1T9] | |
|---|---|
| Metabolite Information | biological process unknown |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | valosin-containing protein [Homo sapiens] | 74 | 0 | 1134 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YDL126c microsomal protein of CDC48PAS1SEC18 family of ATPases | Saccharomyces cerevisiae | 65% | 0 | 1019 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00572 | AAA-protein family signature | 331-349; 605-623; | PS00674 | |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 235-242; 508-515; | PS00017 | |
| PDOC00016 | Cell attachment sequence | 44-46 | PS00016 | |
| PDOC00354 | TonB-dependent receptor proteins signatures | 1-53; | PS00430 | |
| Acylation | N-myristoylation site | 6-11; 147-152; 238-243; 398-403; 511-516; 672-677; 729-734; | PS00008 | |
| Amidation | Amidation site | 51-54; | PS00009 | |
| Glycosylation | N-glycosylation site | 116-119; 250-253; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 175-178; 320-323; 418-421; 457-460; 594-597; 656-659; 671-674; 733-736; 735-738; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 90-92; 133-135; 239-241; 337-339; 365-367; 531-533; 585-587; 611-613; 648-650; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 16-23; 477-485; | PS00007 | |
| Sulfation | Tyrosine sulfation site | 16-30; 186-200; | PS00003 | |
| Transitional endoplasmic reticulum ATPase, putative [Q4Q1T9] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1yqiC | |
| Percent Identity | 74% | |
| Target Region | 1-749 | |
| Template Region | 27-708 | |
| Domain Information | ||
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| Domains | Start | End |
| Active Site Information | ||
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| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 58-64-0 | ADENOSINE-5'-DIPHOSPHATE | 507.181 | C10 H16 N5 O13 P3 | O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O | 1yqi |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2006410/Q4Q1T9.pdb 2.0 733 = residues | | = | *| Ramachandran plot: 72.5% core 22.3% allow 4.7% gener 0.5% = disall | | = | *| All Ramachandrans: 107 labelled residues (out of 716) = | +| Chi1-chi2 plots: 12 labelled residues (out of 456) = | | = | +| Main-chain params: 5 better 0 inside 1 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 7.2 Bad contacts: = 51 | *| Bond len/angle: 11.9 Morris et al class: 2 = 1 3 | | = | +| G-factors Dihedrals: -0.43 Covalent: -0.51 Overall: = -0.44 | | = | | M/c bond lengths: 97.7% within limits 2.3% highlighted = | *| M/c bond angles: 88.8% within limits 11.2% highlighted 8 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |